STRINGSTRING
ENSNLEP00000048966 ENSNLEP00000048966 NOS1 NOS1 SYK SYK CRK CRK SHANK3 SHANK3 LYN LYN PHF6 PHF6 IL6ST IL6ST BRAF BRAF MAP2K2 MAP2K2 KCNH2 KCNH2 NOS3 NOS3 G1QVX5_NOMLE G1QVX5_NOMLE TREM1 TREM1 TREM2 TREM2 CD163 CD163 NLGN1 NLGN1 SHANK1 SHANK1 GRM2 GRM2 ATG4B ATG4B TCOF1 TCOF1 PLCG2 PLCG2 KRT15 KRT15 CAV2 CAV2 DSP DSP CDC37 CDC37 VIM VIM IKBKB IKBKB MAP3K7 MAP3K7 LRP4 LRP4 GRID2 GRID2 XRCC6 XRCC6 P2RX7 P2RX7 PSAP PSAP CRIPT CRIPT KRT18 KRT18 G1S7N4_NOMLE G1S7N4_NOMLE KRT5 KRT5 ATP2B4 ATP2B4 P2RY1 P2RY1 PSAPL1 PSAPL1 AKAP5 AKAP5 ENSNLEP00000025260 ENSNLEP00000025260 CHUK CHUK ENSNLEP00000025842 ENSNLEP00000025842 DLL1 DLL1 PDE4D PDE4D ENSNLEP00000029160 ENSNLEP00000029160 ENSNLEP00000029188 ENSNLEP00000029188 CACNA1G CACNA1G LOC100585323 LOC100585323 NCK2 NCK2 DLG4 DLG4 CACNA1H CACNA1H ENSNLEP00000033584 ENSNLEP00000033584 BAIAP2 BAIAP2 ITPR2 ITPR2 ENSNLEP00000034260 ENSNLEP00000034260 ENSNLEP00000034296 ENSNLEP00000034296 HOMER1 HOMER1 MAP2K1 MAP2K1 ENSNLEP00000036685 ENSNLEP00000036685 ENSNLEP00000037137 ENSNLEP00000037137 CIT CIT ENSNLEP00000037525 ENSNLEP00000037525 NLGN3 NLGN3 ENSNLEP00000039357 ENSNLEP00000039357 CASP8 CASP8 FYN FYN ENSNLEP00000041095 ENSNLEP00000041095 LOC100580083 LOC100580083 ENSNLEP00000041886 ENSNLEP00000041886 ENSNLEP00000042936 ENSNLEP00000042936 YWHAE YWHAE PARK7 PARK7 LOC100580673 LOC100580673 NLGN4X NLGN4X LOC100583245 LOC100583245 ENSNLEP00000046012 ENSNLEP00000046012 SCN5A SCN5A ENSNLEP00000046451 ENSNLEP00000046451 ENSNLEP00000047093 ENSNLEP00000047093 ENSNLEP00000047501 ENSNLEP00000047501 ADCY5 ADCY5 ENSNLEP00000048416 ENSNLEP00000048416 SRC SRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSNLEP00000048966IF rod domain-containing protein; Belongs to the intermediate filament family. (171 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
SYKTyrosine-protein kinase. (532 aa)
CRKUncharacterized protein. (252 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1521 aa)
LYNTyrosine-protein kinase. (512 aa)
PHF6PHD finger protein 6. (366 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (383 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1085 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
G1QVX5_NOMLEUncharacterized protein. (361 aa)
TREM1Triggering receptor expressed on myeloid cells 1. (234 aa)
TREM2Ig-like domain-containing protein. (222 aa)
CD163CD163 molecule. (1156 aa)
NLGN1Neuroligin 1. (823 aa)
SHANK1Uncharacterized protein. (1415 aa)
GRM2Glutamate metabotropic receptor 2. (873 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1467 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
KRT15Keratin 15; Belongs to the intermediate filament family. (437 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
DSPDesmoplakin. (2817 aa)
CDC37Cell division cycle 37. (355 aa)
VIMIF rod domain-containing protein; Belongs to the intermediate filament family. (228 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LRP4LDL receptor related protein 4. (1904 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
XRCC6X-ray repair cross complementing 6. (535 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (522 aa)
CRIPTCXXC repeat containing interactor of PDZ3 domain. (101 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (430 aa)
G1S7N4_NOMLEIF rod domain-containing protein; Belongs to the intermediate filament family. (396 aa)
KRT5Keratin 5; Belongs to the intermediate filament family. (594 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1241 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PSAPL1Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. (521 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
ENSNLEP00000025260IF rod domain-containing protein; Belongs to the intermediate filament family. (286 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
ENSNLEP00000025842IF rod domain-containing protein; Belongs to the intermediate filament family. (465 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
PDE4DPhosphodiesterase. (748 aa)
ENSNLEP00000029160IF rod domain-containing protein; Belongs to the intermediate filament family. (143 aa)
ENSNLEP00000029188Uncharacterized protein. (60 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2317 aa)
LOC100585323IF rod domain-containing protein; Belongs to the intermediate filament family. (452 aa)
NCK2Cytoplasmic protein. (380 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (746 aa)
CACNA1HUncharacterized protein. (2096 aa)
ENSNLEP00000033584IF rod domain-containing protein; Belongs to the intermediate filament family. (413 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
ENSNLEP00000034260IF rod domain-containing protein; Belongs to the intermediate filament family. (239 aa)
ENSNLEP00000034296DJ-1_PfpI domain-containing protein. (133 aa)
HOMER1Homer scaffold protein 1. (377 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSNLEP00000036685Ku domain-containing protein. (329 aa)
ENSNLEP00000037137SAP domain-containing protein. (225 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2048 aa)
ENSNLEP00000037525IF rod domain-containing protein; Belongs to the intermediate filament family. (426 aa)
NLGN3Neuroligin 3. (912 aa)
ENSNLEP00000039357Ku domain-containing protein. (451 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSNLEP00000041095IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
LOC100580083IF rod domain-containing protein; Belongs to the intermediate filament family. (437 aa)
ENSNLEP00000041886Ion_trans domain-containing protein; Belongs to the potassium channel family. (359 aa)
ENSNLEP00000042936Protein kinase domain-containing protein. (201 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
LOC100580673Ku domain-containing protein. (534 aa)
NLGN4XNeuroligin 4 X-linked. (836 aa)
LOC10058324514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
ENSNLEP00000046012IF rod domain-containing protein; Belongs to the intermediate filament family. (198 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1925 aa)
ENSNLEP00000046451IF rod domain-containing protein; Belongs to the intermediate filament family. (417 aa)
ENSNLEP00000047093IF rod domain-containing protein; Belongs to the intermediate filament family. (440 aa)
ENSNLEP00000047501IF rod domain-containing protein; Belongs to the intermediate filament family. (376 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
ENSNLEP00000048416IF rod domain-containing protein; Belongs to the intermediate filament family. (305 aa)
SRCTyrosine-protein kinase. (537 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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