STRINGSTRING
CD70 CD70 P2RX7 P2RX7 SIVA1 SIVA1 BAG3 BAG3 MOAP1 MOAP1 KRT18 KRT18 ACVR1B ACVR1B COL2A1 COL2A1 PTPRC PTPRC DEDD2 DEDD2 ITPRIP ITPRIP FGFR3 FGFR3 GSK3B GSK3B STK3 STK3 DDX3X DDX3X DELE1 DELE1 STK4 STK4 ENSNLEP00000028972 ENSNLEP00000028972 FGF10 FGF10 ENSNLEP00000029160 ENSNLEP00000029160 TNFRSF1A TNFRSF1A TNFRSF10D TNFRSF10D HIPK1 HIPK1 ENSNLEP00000031524 ENSNLEP00000031524 YAP1 YAP1 PIK3R1 PIK3R1 ENSNLEP00000032543 ENSNLEP00000032543 GABARAP GABARAP CTNNA1 CTNNA1 ENSNLEP00000033584 ENSNLEP00000033584 TNFSF12 TNFSF12 BAK1 BAK1 IL6R IL6R ITGAV ITGAV ZDHHC3 ZDHHC3 BCL2 BCL2 BID BID BAD BAD DDX47 DDX47 ENSNLEP00000040381 ENSNLEP00000040381 NF1 NF1 CASP8 CASP8 LOC100593010 LOC100593010 IL7 IL7 SMAD3 SMAD3 BEX3 BEX3 PIDD1 PIDD1 ENSNLEP00000044067 ENSNLEP00000044067 EYA1 EYA1 SKIL SKIL DAB2IP DAB2IP IL1B IL1B CASP7 CASP7 BCL2A1 BCL2A1 ENSNLEP00000046012 ENSNLEP00000046012 MLLT11 MLLT11 ENSNLEP00000046451 ENSNLEP00000046451 PML PML ERBB3 ERBB3 SGPP1 SGPP1 ENSNLEP00000047501 ENSNLEP00000047501 TNF TNF ENSNLEP00000048966 ENSNLEP00000048966 G0S2 G0S2 RB1CC1 RB1CC1 IL1A IL1A MKNK2 MKNK2 BCL2L11 BCL2L11 SORT1 SORT1 CX3CL1 CX3CL1 INHBA INHBA CASP2 CASP2 IFNG IFNG CD27 CD27 TRADD TRADD IL12A IL12A BAX BAX DAPK1 DAPK1 ITPRIPL2 ITPRIPL2 PDIA3 PDIA3 KITLG KITLG NDUFA13 NDUFA13 BCL2L10 BCL2L10 EYA2 EYA2 BOK BOK JAK2 JAK2 IL33 IL33 LOC100592336 LOC100592336 IL2 IL2 BCL2L1 BCL2L1 TNFRSF1B TNFRSF1B MCL1 MCL1 FADD FADD CTTN CTTN GSK3A GSK3A PARP2 PARP2 RNF41 RNF41 RIPK1 RIPK1 TLR3 TLR3 FAS FAS SFRP1 SFRP1 IL4 IL4 CASP8AP2 CASP8AP2 WWOX WWOX TGFB1 TGFB1 DEDD DEDD TGFB2 TGFB2 SPI1 SPI1 FASLG FASLG G1S167_NOMLE G1S167_NOMLE TNFRSF10A TNFRSF10A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD70Tumor necrosis factor ligand 8A; Belongs to the tumor necrosis factor family. (193 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
BAG3BCL2 associated athanogene 3. (574 aa)
MOAP1Modulator of apoptosis 1. (351 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (430 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
DEDD2Death effector domain containing 2. (326 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (458 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
STK3Serine/threonine kinase 3. (519 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (704 aa)
DELE1DAP3 binding cell death enhancer 1. (536 aa)
STK4Serine/threonine kinase 4. (490 aa)
ENSNLEP00000028972Uncharacterized protein. (122 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSNLEP00000029160IF rod domain-containing protein; Belongs to the intermediate filament family. (143 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
TNFRSF10DUncharacterized protein. (226 aa)
HIPK1Homeodomain interacting protein kinase 1. (1142 aa)
ENSNLEP00000031524Uncharacterized protein. (55 aa)
YAP1Uncharacterized protein. (418 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
CTNNA1Catenin alpha 1. (895 aa)
ENSNLEP00000033584IF rod domain-containing protein; Belongs to the intermediate filament family. (413 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
IL6RInterleukin 6 receptor. (420 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1008 aa)
ZDHHC3Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (333 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (214 aa)
BADUncharacterized protein. (82 aa)
DDX47DEAD-box helicase 47; Belongs to the DEAD box helicase family. (455 aa)
ENSNLEP00000040381Uncharacterized protein. (760 aa)
NF1Neurofibromin 1. (2839 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
IL7Interleukin 7. (179 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BEX3Brain expressed X-linked 3. (121 aa)
PIDD1P53-induced death domain protein 1. (883 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SKILSKI like proto-oncogene. (683 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (387 aa)
BCL2A1Uncharacterized protein. (205 aa)
ENSNLEP00000046012IF rod domain-containing protein; Belongs to the intermediate filament family. (198 aa)
MLLT11MLLT11 transcription factor 7 cofactor. (90 aa)
ENSNLEP00000046451IF rod domain-containing protein; Belongs to the intermediate filament family. (417 aa)
PMLUncharacterized protein. (873 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (381 aa)
ENSNLEP00000047501IF rod domain-containing protein; Belongs to the intermediate filament family. (376 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSNLEP00000048966IF rod domain-containing protein; Belongs to the intermediate filament family. (171 aa)
G0S2G0/G1 switch 2. (103 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (247 aa)
MKNK2Uncharacterized protein. (272 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
SORT1Sortilin. (694 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
INHBAInhibin subunit beta A. (426 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CD27CD27 molecule. (259 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (203 aa)
BAXUncharacterized protein. (194 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
ITPRIPL2ITPRIP like 2. (535 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
BCL2L10BCL2 like 10. (231 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (512 aa)
BOKBCL2 family apoptosis regulator BOK. (211 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
IL33Interleukin 33. (270 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
BCL2L1BCL2 like 1. (217 aa)
TNFRSF1BTNF receptor superfamily member 1B. (424 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CTTNSH3 domain-containing protein. (549 aa)
GSK3AGlycogen synthase kinase 3 alpha. (439 aa)
PARP2Poly [ADP-ribose] polymerase. (583 aa)
RNF41Ring finger protein 41. (317 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
FASFas cell surface death receptor. (335 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
CASP8AP2Caspase 8 associated protein 2. (1971 aa)
WWOXWW domain containing oxidoreductase. (413 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DEDDDeath effector domain containing. (347 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
G1S167_NOMLEUncharacterized protein. (410 aa)
TNFRSF10ATNF receptor superfamily member 10a. (471 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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