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EDNRA EDNRA CASR CASR NOS1 NOS1 AVPR1B AVPR1B BDKRB2 BDKRB2 HRH2 HRH2 EDN1 EDN1 MMP2 MMP2 CALCA CALCA AGT AGT TBXAS1 TBXAS1 CYSLTR1 CYSLTR1 BBS2 BBS2 TBXA2R TBXA2R KEL KEL UCN UCN GCLC GCLC SOD1 SOD1 SLC6A4 SLC6A4 NOS3 NOS3 ADRA1B ADRA1B EXT1 EXT1 GRIP2 GRIP2 G1QZ78_NOMLE G1QZ78_NOMLE KLF2 KLF2 ROCK1 ROCK1 ARHGAP42 ARHGAP42 ITGB1BP1 ITGB1BP1 ATP1A2 ATP1A2 HTR2B HTR2B OXTR OXTR PLOD3 PLOD3 UTS2 UTS2 NPPB NPPB SNTA1 SNTA1 NPR1 NPR1 GCLM GCLM ITGA1 ITGA1 DOCK4 DOCK4 PER2 PER2 PRKG1 PRKG1 EDN2 EDN2 ABL1 ABL1 F2R F2R GCH1 GCH1 SMTNL1 SMTNL1 CRP CRP ATG5 ATG5 DBH DBH AVPR2 AVPR2 NPR3 NPR3 MKKS MKKS ADORA2B ADORA2B ADORA2A ADORA2A VSTM4 VSTM4 EDNRB EDNRB FAAH FAAH AVPR1A AVPR1A P2RY2 P2RY2 SERPINF2 SERPINF2 P2RX1 P2RX1 ADM ADM ZDHHC21 ZDHHC21 EXT2 EXT2 PTGS2 PTGS2 RGS2 RGS2 HTR1A HTR1A HTR1B HTR1B ADRA2C ADRA2C UTS2R UTS2R HRH1 HRH1 P2RY1 P2RY1 ADRB1 ADRB1 ADRB3 ADRB3 PPARD PPARD GPER1 GPER1 SCPEP1 SCPEP1 F2RL1 F2RL1 KCNMB4 KCNMB4 HTR7 HTR7 TACR1 TACR1 CD38 CD38 CPS1 CPS1 ENSNLEP00000028086 ENSNLEP00000028086 ATP2B1 ATP2B1 MTNR1B MTNR1B KCNMA1 KCNMA1 SLC8A1 SLC8A1 ADCY6 ADCY6 SMTNL2 SMTNL2 CAV1 CAV1 ADRA1A ADRA1A ENSNLEP00000032236 ENSNLEP00000032236 GJA5 GJA5 RAP1GDS1 RAP1GDS1 AGTR2 AGTR2 ROCK2 ROCK2 SOD3 SOD3 ENSNLEP00000036737 ENSNLEP00000036737 PLA2G6 PLA2G6 TRPM4 TRPM4 ADRA2B ADRA2B CBS CBS DRD1 DRD1 HTR2A HTR2A FGG FGG EDN3 EDN3 BMPR2 BMPR2 AGTR1 AGTR1 KCNMB2 KCNMB2 COMP COMP LOC100592187 LOC100592187 FGB FGB FGA FGA GUCY1A1 GUCY1A1 KNG1 KNG1 UTS2B UTS2B RHOA RHOA AVP AVP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CASRCalcium sensing receptor. (1088 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (426 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (386 aa)
HRH2Histamine receptor H2; Belongs to the G-protein coupled receptor 1 family. (422 aa)
EDN1Endothelin 1. (211 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (580 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (337 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
KELKell metallo-endopeptidase (Kell blood group). (720 aa)
UCNUrocortin. (124 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (625 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
ADRA1BG_PROTEIN_RECEP_F1_2 domain-containing protein. (384 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (745 aa)
GRIP2Glutamate receptor interacting protein 2. (1142 aa)
G1QZ78_NOMLEUncharacterized protein. (162 aa)
KLF2Kruppel like factor 2. (355 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
ARHGAP42Rho GTPase activating protein 42. (867 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
HTR2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (398 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (628 aa)
UTS2Urotensin 2. (139 aa)
NPPBNatriuretic peptide B. (134 aa)
SNTA1Syntrophin alpha 1. (501 aa)
NPR1Guanylate cyclase. (914 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (2019 aa)
PER2Period circadian regulator 2. (1277 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
EDN2Endothelin 2. (177 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
SMTNL1Smoothelin like 1. (493 aa)
CRPPentaxin. (224 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
DBHDopamine beta-hydroxylase. (611 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
NPR3Natriuretic peptide receptor 3. (537 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (329 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
VSTM4V-set and transmembrane domain containing 4. (320 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
FAAHFatty acid amide hydrolase. (579 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (405 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (468 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (379 aa)
ADMAdrenomedullin. (184 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (751 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ADRA2CG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
UTS2RUrotensin 2 receptor; Belongs to the G-protein coupled receptor 1 family. (389 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (487 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
ADRB1Adrenoceptor beta 1. (476 aa)
ADRB3G_PROTEIN_RECEP_F1_2 domain-containing protein. (402 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
SCPEP1Carboxypeptidase; Belongs to the peptidase S10 family. (452 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
HTR7G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (325 aa)
TACR1Tachykinin receptor 1. (406 aa)
CD38CD38 molecule. (300 aa)
CPS1Carbamoyl-phosphate synthase 1. (1506 aa)
ENSNLEP00000028086Fork-head domain-containing protein. (459 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
MTNR1BUncharacterized protein. (89 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1289 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1055 aa)
SMTNL2Calponin-homology (CH) domain-containing protein. (317 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
ENSNLEP00000032236Uncharacterized protein. (109 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1. (626 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
TRPM4Uncharacterized protein. (1010 aa)
ADRA2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
FGGFibrinogen gamma chain. (463 aa)
EDN3Uncharacterized protein. (211 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
COMPTSP C-terminal domain-containing protein. (194 aa)
LOC100592187Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (293 aa)
FGBFibrinogen beta chain. (491 aa)
FGAFibrinogen alpha chain. (863 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
KNG1Kininogen 1. (644 aa)
UTS2BUrotensin 2B. (119 aa)
RHOARas homolog family member A. (193 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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