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BRAF BRAF RPH3A RPH3A SYK SYK RPH3AL RPH3AL FBXL20 FBXL20 SNX4 SNX4 STXBP2 STXBP2 LYN LYN CBARP CBARP UNC13D UNC13D PRAM1 PRAM1 STXBP3 STXBP3 CASK CASK CD300A CD300A ITGB2 ITGB2 KIAA0100 KIAA0100 TRPV6 TRPV6 C12orf4 C12orf4 VPS18 VPS18 RAP1A RAP1A CDK5 CDK5 G1QVV4_NOMLE G1QVV4_NOMLE PLA2G3 PLA2G3 SYT1 SYT1 LOC100592911 LOC100592911 STXBP5L STXBP5L SEPTIN5 SEPTIN5 NLGN1 NLGN1 CD160 CD160 SYT3 SYT3 RAB3A RAB3A PRKCG PRKCG SYT12 SYT12 CSPG5 CSPG5 RAB27A RAB27A RIMS4 RIMS4 GNAI2 GNAI2 KCNB1 KCNB1 HYAL3 HYAL3 DOC2A DOC2A GATA1 GATA1 SYP SYP NOTCH1 NOTCH1 ZP3 ZP3 RAB3GAP1 RAB3GAP1 BAIAP3 BAIAP3 CHRNA5 CHRNA5 REST REST LOC100592336 LOC100592336 PTAFR PTAFR GIPC2 GIPC2 SYT4 SYT4 CEACAM1 CEACAM1 FER FER FOXF1 FOXF1 IL4R IL4R RIMS3 RIMS3 FES FES SYT11 SYT11 RAB3D RAB3D MICAL1 MICAL1 IL4 IL4 FMR1 FMR1 SYT8 SYT8 GIPC1 GIPC1 CD84 CD84 GATA2 GATA2 SPI1 SPI1 IL13RA2 IL13RA2 ADORA2B ADORA2B CACNA1I CACNA1I ADORA2A ADORA2A P2RX7 P2RX7 STX4 STX4 ITGAM ITGAM SYT10 SYT10 NRXN3 NRXN3 PREPL PREPL GRIN3A GRIN3A P2RX1 P2RX1 SYT9 SYT9 SLC4A8 SLC4A8 LRRK2 LRRK2 SYT13 SYT13 CDK5R2 CDK5R2 P2RY1 P2RY1 SYN1 SYN1 BLK BLK ENSNLEP00000024537 ENSNLEP00000024537 F2RL1 F2RL1 ENSNLEP00000025590 ENSNLEP00000025590 GSK3B GSK3B LAMP1 LAMP1 LOC100581641 LOC100581641 SNAPIN SNAPIN CD177 CD177 APBA1 APBA1 DTNBP1 DTNBP1 CACNB4 CACNB4 DRD2 DRD2 CALM1 CALM1 ENSNLEP00000029648 ENSNLEP00000029648 CHRM2 CHRM2 RAP1B RAP1B CACNA1G CACNA1G SPHK2 SPHK2 CACNA1H CACNA1H SYT6 SYT6 STX1A STX1A FGR FGR NCKAP1L NCKAP1L RABGEF1 RABGEF1 STXBP5 STXBP5 ENSNLEP00000036455 ENSNLEP00000036455 ENSNLEP00000036861 ENSNLEP00000036861 GIPC3 GIPC3 SYT7 SYT7 SYT15 SYT15 DRD1 DRD1 HTR2A HTR2A SYNPR SYNPR FCGR2B FCGR2B LOC100593010 LOC100593010 BACE1 BACE1 GIT1 GIT1 VAMP8 VAMP8 RAC2 RAC2 DVL1 DVL1 SYT5 SYT5 CACNB2 CACNB2 ADRA1A ADRA1A PRKCB PRKCB ATP2A2 ATP2A2 BCR BCR DGKI DGKI ADCY1 ADCY1 SYT2 SYT2 SCAMP5 SCAMP5 ENSNLEP00000048405 ENSNLEP00000048405 RAB15 RAB15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
RPH3ARabphilin 3A. (693 aa)
SYKTyrosine-protein kinase. (532 aa)
RPH3ALRabphilin 3A like (without C2 domains). (314 aa)
FBXL20F-box and leucine rich repeat protein 20. (425 aa)
SNX4Sorting nexin 4. (442 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (579 aa)
LYNTyrosine-protein kinase. (512 aa)
CBARPUncharacterized protein. (667 aa)
UNC13DUnc-13 homolog D. (1082 aa)
PRAM1SH3 domain-containing protein. (564 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (912 aa)
CD300ACD300a molecule. (299 aa)
ITGB2Integrin beta. (762 aa)
KIAA0100KIAA0100. (2146 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (765 aa)
C12orf4Chromosome 12 open reading frame 4. (552 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (972 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
G1QVV4_NOMLEGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (292 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
SYT1Synaptotagmin 1. (422 aa)
LOC100592911Ig-like domain-containing protein; Belongs to the MHC class I family. (295 aa)
STXBP5LSyntaxin binding protein 5 like. (1177 aa)
SEPTIN5Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (323 aa)
NLGN1Neuroligin 1. (823 aa)
CD160CD160 molecule. (181 aa)
SYT3Synaptotagmin 3. (584 aa)
RAB3ARAB3A, member RAS oncogene family. (186 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SYT12Synaptotagmin 12. (421 aa)
CSPG5Uncharacterized protein. (321 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (216 aa)
GNAI2G protein subunit alpha i2. (355 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
DOC2ADouble C2 domain alpha. (355 aa)
GATA1GATA binding protein 1. (413 aa)
SYPSynaptophysin. (313 aa)
NOTCH1Notch receptor 1. (2451 aa)
ZP3ZP domain-containing protein. (349 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (980 aa)
BAIAP3BAI1 associated protein 3. (1094 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (455 aa)
RESTRE1 silencing transcription factor. (1097 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
GIPC2GIPC PDZ domain containing family member 2. (287 aa)
SYT4Synaptotagmin 4. (425 aa)
CEACAM1Uncharacterized protein. (493 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FOXF1Uncharacterized protein. (361 aa)
IL4RInterleukin 4 receptor. (810 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (828 aa)
SYT11Synaptotagmin 11. (431 aa)
RAB3DRAB3D, member RAS oncogene family. (219 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1086 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
FMR1Fragile X mental retardation 1. (632 aa)
SYT8Synaptotagmin 8. (400 aa)
GIPC1PDZ domain-containing protein. (225 aa)
CD84CD84 molecule. (339 aa)
GATA2GATA binding protein 2. (480 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (380 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (329 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (2052 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (992 aa)
SYT10Synaptotagmin 10. (523 aa)
NRXN3Uncharacterized protein. (1061 aa)
PREPLProlyl endopeptidase like. (727 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1119 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (379 aa)
SYT9Synaptotagmin 9. (472 aa)
SLC4A8Anion exchange protein. (1093 aa)
LRRK2Leucine rich repeat kinase 2. (2527 aa)
SYT13Synaptotagmin 13. (426 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
SYN1Synapsin I. (639 aa)
BLKTyrosine-protein kinase. (505 aa)
ENSNLEP00000024537A20-type domain-containing protein. (112 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ENSNLEP00000025590Ig-like domain-containing protein; Belongs to the MHC class I family. (340 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
LAMP1Lysosomal associated membrane protein 1. (416 aa)
LOC100581641Uncharacterized protein. (352 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
CD177Uncharacterized protein. (140 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (839 aa)
DTNBP1Dystrobrevin binding protein 1. (350 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (502 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (445 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
ENSNLEP00000029648Ig-like domain-containing protein; Belongs to the MHC class I family. (411 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
RAP1BRAP1B, member of RAS oncogene family. (165 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2317 aa)
SPHK2Sphingosine kinase 2. (630 aa)
CACNA1HUncharacterized protein. (2096 aa)
SYT6Uncharacterized protein. (480 aa)
STX1At-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (243 aa)
FGRTyrosine-protein kinase. (476 aa)
NCKAP1LNCK associated protein 1 like. (1109 aa)
RABGEF1RAB guanine nucleotide exchange factor 1. (497 aa)
STXBP5Syntaxin binding protein 5. (1153 aa)
ENSNLEP00000036455Uncharacterized protein. (127 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
GIPC3GIPC PDZ domain containing family member 3. (284 aa)
SYT7Uncharacterized protein. (592 aa)
SYT15Uncharacterized protein. (474 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
SYNPRSynaptoporin. (285 aa)
FCGR2BUncharacterized protein. (310 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
GIT1GIT ArfGAP 1. (772 aa)
VAMP8V-SNARE coiled-coil homology domain-containing protein. (116 aa)
RAC2Rac family small GTPase 2. (192 aa)
DVL1Dishevelled segment polarity protein 1. (667 aa)
SYT5C2 domain-containing protein. (235 aa)
CACNB2GuKc domain-containing protein. (586 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
DGKIDiacylglycerol kinase. (1026 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
SYT2Synaptotagmin 2. (419 aa)
SCAMP5Secretory carrier-associated membrane protein. (242 aa)
ENSNLEP00000048405Uncharacterized protein. (167 aa)
RAB15Uncharacterized protein. (244 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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