STRINGSTRING
RYR2 RYR2 ENSNLEP00000048966 ENSNLEP00000048966 MAP3K5 MAP3K5 TNF TNF ENSNLEP00000047501 ENSNLEP00000047501 COL4A3 COL4A3 ENSNLEP00000046451 ENSNLEP00000046451 ENSNLEP00000046012 ENSNLEP00000046012 HMOX1 HMOX1 DAB2IP DAB2IP BMPR2 BMPR2 GSN GSN CAPN10 CAPN10 SAV1 SAV1 BID BID BCL2 BCL2 LEF1 LEF1 ATF2 ATF2 ENSNLEP00000033584 ENSNLEP00000033584 ARF6 ARF6 HIPK1 HIPK1 ENSNLEP00000029160 ENSNLEP00000029160 STK4 STK4 ENSNLEP00000027513 ENSNLEP00000027513 STK3 STK3 CDKN1B CDKN1B DNMT3A DNMT3A ATOH1 ATOH1 KRT18 KRT18 AGAP2 AGAP2 WNT11 WNT11 CASP6 CASP6 JAG2 JAG2 NKX2-6 NKX2-6 EXOC5 EXOC5 ABL1 ABL1 ADAR ADAR CASP3 CASP3 E2F1 E2F1 BCL2L1 BCL2L1 PIK3CG PIK3CG E2F2 E2F2 BTC BTC CASP9 CASP9 HAND2 HAND2 EDNRA EDNRA FGF21 FGF21 TGFBR2 TGFBR2 RB1 RB1 BRAF BRAF TMF1 TMF1 ANGPTL4 ANGPTL4 NKX2-5 NKX2-5 PDX1 PDX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYR2Ryanodine receptor 2. (4825 aa)
ENSNLEP00000048966IF rod domain-containing protein; Belongs to the intermediate filament family. (171 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ENSNLEP00000047501IF rod domain-containing protein; Belongs to the intermediate filament family. (376 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
ENSNLEP00000046451IF rod domain-containing protein; Belongs to the intermediate filament family. (417 aa)
ENSNLEP00000046012IF rod domain-containing protein; Belongs to the intermediate filament family. (198 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
DAB2IPDAB2 interacting protein. (1159 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
GSNGelsolin. (814 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (214 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSNLEP00000033584IF rod domain-containing protein; Belongs to the intermediate filament family. (413 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
HIPK1Homeodomain interacting protein kinase 1. (1142 aa)
ENSNLEP00000029160IF rod domain-containing protein; Belongs to the intermediate filament family. (143 aa)
STK4Serine/threonine kinase 4. (490 aa)
ENSNLEP00000027513Uncharacterized protein. (154 aa)
STK3Serine/threonine kinase 3. (519 aa)
CDKN1BUncharacterized protein. (204 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (880 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (430 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1186 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
JAG2Jagged canonical Notch ligand 2. (1238 aa)
NKX2-6NK2 homeobox 6. (301 aa)
EXOC5Exocyst complex component 5. (680 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
ADARAdenosine deaminase RNA specific. (1180 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
E2F1E2F transcription factor 1. (391 aa)
BCL2L1BCL2 like 1. (217 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
E2F2E2F transcription factor 2. (437 aa)
BTCBetacellulin. (178 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
HAND2Heart and neural crest derivatives expressed 2. (198 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
RB1RB transcriptional corepressor 1. (919 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
TMF1TATA element modulatory factor 1. (1096 aa)
ANGPTL4Angiopoietin like 4. (379 aa)
NKX2-5NK2 homeobox 5. (317 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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