STRINGSTRING
RYR2 RYR2 VMP1 VMP1 WNK2 WNK2 LOC100606903 LOC100606903 SUMO1 SUMO1 WNK1 WNK1 ENSNLEP00000044651 ENSNLEP00000044651 ENSNLEP00000044067 ENSNLEP00000044067 P2RX4 P2RX4 KCNC2 KCNC2 HTT HTT TESC TESC NOS1 NOS1 EDN1 EDN1 G1QJ30_NOMLE G1QJ30_NOMLE CXCR3 CXCR3 SHANK3 SHANK3 GRM6 GRM6 KCNN4 KCNN4 GALR2 GALR2 CX3CL1 CX3CL1 AMIGO1 AMIGO1 CRACR2A CRACR2A AKAP6 AKAP6 CHP1 CHP1 ACTN2 ACTN2 RGS7 RGS7 LOC101177715 LOC101177715 IFNGR2 IFNGR2 KCNH2 KCNH2 CDK5 CDK5 RAMP3 RAMP3 CAPN3 CAPN3 BAX BAX IAPP IAPP STAC STAC TRPC1 TRPC1 TREM2 TREM2 G1QZ78_NOMLE G1QZ78_NOMLE PDZK1 PDZK1 EDNRA EDNRA PLCG1 PLCG1 JPH2 JPH2 GAL GAL CXCL11 CXCL11 CXCL9 CXCL9 CXCL10 CXCL10 ANTKMT ANTKMT DRD4 DRD4 R3HDM1 R3HDM1 LHCGR LHCGR CEMIP CEMIP RELN RELN TRPC3 TRPC3 LOC100592336 LOC100592336 ACE2 ACE2 G1RE82_NOMLE G1RE82_NOMLE SLC9A1 SLC9A1 PKD2 PKD2 ATP1B2 ATP1B2 LRRC38 LRRC38 NTSR1 NTSR1 CTSS CTSS RNF207 RNF207 PLCG2 PLCG2 HAP1 HAP1 FXYD1 FXYD1 CD19 CD19 WNK4 WNK4 CHP2 CHP2 ANK3 ANK3 LRRC55 LRRC55 APLNR APLNR ABL1 ABL1 F2R F2R P2RX3 P2RX3 CASQ1 CASQ1 FLNA FLNA F2 F2 GLRX GLRX G6PD G6PD AKAP7 AKAP7 SNCA SNCA CACNG2 CACNG2 LRRC52 LRRC52 CACNA2D1 CACNA2D1 ATP1B1 ATP1B1 SRI SRI AKAP9 AKAP9 GSTO1 GSTO1 CALCR CALCR EHD3 EHD3 PPP3CC PPP3CC PLA2G1B PLA2G1B NIPSNAP2 NIPSNAP2 P2RX7 P2RX7 WNK3 WNK3 ANK2 ANK2 P2RX5 P2RX5 P2RX1 P2RX1 STAC3 STAC3 TOR2A TOR2A KCNC1 KCNC1 CACNB3 CACNB3 ANO6 ANO6 PIRT PIRT AMIGO3 AMIGO3 BDKRB1 BDKRB1 KCNA1 KCNA1 KCNK3 KCNK3 AKAP5 AKAP5 HSPA2 HSPA2 NOS1AP NOS1AP PINK1 PINK1 GPER1 GPER1 TRDN TRDN ATPSCKMT ATPSCKMT ASPH ASPH ENSNLEP00000025216 ENSNLEP00000025216 PPP3R1 PPP3R1 PPP3CB PPP3CB NPSR1 NPSR1 ENSNLEP00000028440 ENSNLEP00000028440 DNM2 DNM2 STIM1 STIM1 CACNB4 CACNB4 KCNJ2 KCNJ2 CALM1 CALM1 ENSNLEP00000031088 ENSNLEP00000031088 ADCYAP1R1 ADCYAP1R1 MS4A1 MS4A1 PPP3CA PPP3CA ENSNLEP00000031915 ENSNLEP00000031915 CAV1 CAV1 DMD DMD BAK1 BAK1 ENSNLEP00000035652 ENSNLEP00000035652 CACNG4 CACNG4 KCNE2 KCNE2 ENSNLEP00000036861 ENSNLEP00000036861 GRIN1 GRIN1 LOC100580006 LOC100580006 ATP1B3 ATP1B3 ATP2A1 ATP2A1 NLGN3 NLGN3 FXYD2 FXYD2 ENSNLEP00000039267 ENSNLEP00000039267 DRD1 DRD1 LACRT LACRT R3HDM2 R3HDM2 STIM2 STIM2 LOC100593010 LOC100593010 P2RY6 P2RY6 THY1 THY1 ABCC8 ABCC8 EDN3 EDN3 ENSNLEP00000041886 ENSNLEP00000041886 EPHB2 EPHB2 CACNB2 CACNB2 KCNIP2 KCNIP2 ENSNLEP00000043731 ENSNLEP00000043731
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYR2Ryanodine receptor 2. (4825 aa)
VMP1Uncharacterized protein. (406 aa)
WNK2WNK lysine deficient protein kinase 2. (1977 aa)
LOC100606903Uncharacterized protein; Belongs to the GST superfamily. (236 aa)
SUMO1Small ubiquitin-related modifier. (88 aa)
WNK1WNK lysine deficient protein kinase 1. (2833 aa)
ENSNLEP00000044651EF-hand domain-containing protein. (184 aa)
ENSNLEP00000044067Uncharacterized protein. (108 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (404 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
HTTHuntingtin. (3048 aa)
TESCTescalcin. (214 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
EDN1Endothelin 1. (211 aa)
G1QJ30_NOMLEUncharacterized protein. (363 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1521 aa)
GRM6Glutamate metabotropic receptor 6. (865 aa)
KCNN4CaMBD domain-containing protein. (702 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
CRACR2ACalcium release activated channel regulator 2A. (721 aa)
AKAP6A-kinase anchoring protein 6. (2238 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
ACTN2Actinin alpha 2. (854 aa)
RGS7Regulator of G protein signaling 7. (487 aa)
LOC101177715AIG1-type G domain-containing protein. (307 aa)
IFNGR2Interferon gamma receptor 2. (314 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1085 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
RAMP3Receptor activity modifying protein 3. (148 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (837 aa)
BAXUncharacterized protein. (194 aa)
IAPPIslet amyloid polypeptide. (89 aa)
STACSH3 and cysteine rich domain. (402 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (881 aa)
TREM2Ig-like domain-containing protein. (222 aa)
G1QZ78_NOMLEUncharacterized protein. (162 aa)
PDZK1PDZ domain containing 1. (519 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (680 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
CXCL11C-X-C motif chemokine. (94 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CXCL10C-X-C motif chemokine. (98 aa)
ANTKMTAdenine nucleotide translocase lysine methyltransferase. (235 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (386 aa)
R3HDM1R3H domain containing 1. (1100 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
CEMIPCell migration inducing hyaluronidase 1. (1357 aa)
RELNReelin. (3460 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
G1RE82_NOMLECollectrin domain-containing protein. (199 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
LRRC38Leucine rich repeat containing 38. (294 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
RNF207Ring finger protein 207. (634 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
HAP1Huntingtin associated protein 1. (624 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (70 aa)
CD19CD19 molecule. (558 aa)
WNK4WNK lysine deficient protein kinase 4. (1037 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
ANK3Ankyrin 3. (4058 aa)
LRRC55Leucine rich repeat containing 55. (341 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (381 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (121 aa)
FLNAFilamin A. (2626 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (613 aa)
GLRXGlutaredoxin. (106 aa)
G6PDUncharacterized protein. (452 aa)
AKAP7A-kinase anchoring protein 7. (348 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
LRRC52Leucine rich repeat containing 52. (313 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1071 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
SRISorcin. (221 aa)
AKAP9A-kinase anchoring protein 9. (3896 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (478 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
PLA2G1BPhospholipase A(2). (148 aa)
NIPSNAP2Nipsnap homolog 2. (263 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
WNK3WNK lysine deficient protein kinase 3. (1800 aa)
ANK2Ankyrin 2. (3957 aa)
P2RX5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (422 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (379 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
TOR2ATorsin. (321 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (444 aa)
ANO6Anoctamin. (931 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (504 aa)
BDKRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (284 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
KCNK3Ion_trans_2 domain-containing protein. (271 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (601 aa)
NOS1APPID domain-containing protein. (485 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
TRDNTriadin. (728 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (232 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
ENSNLEP00000025216Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (256 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
NPSR1Neuropeptide S receptor 1. (391 aa)
ENSNLEP00000028440Uncharacterized protein. (95 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (770 aa)
STIM1Stromal interaction molecule 1. (818 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (502 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (500 aa)
MS4A1Membrane spanning 4-domains A1. (297 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSNLEP00000031915Ubiquitin-like domain-containing protein. (93 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
DMDDystrophin. (3685 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
ENSNLEP00000035652Uncharacterized protein; Belongs to the calmodulin family. (123 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (888 aa)
LOC100580006Uncharacterized protein. (371 aa)
ATP1B3Uncharacterized protein. (89 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1031 aa)
NLGN3Neuroligin 3. (912 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
ENSNLEP00000039267Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (234 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
LACRTUncharacterized protein. (102 aa)
R3HDM2R3H domain containing 2. (1033 aa)
STIM2Stromal interaction molecule 2. (841 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
THY1Ig-like domain-containing protein. (216 aa)
ABCC8ATP binding cassette subfamily C member 8. (1569 aa)
EDN3Uncharacterized protein. (211 aa)
ENSNLEP00000041886Ion_trans domain-containing protein; Belongs to the potassium channel family. (359 aa)
EPHB2EPH receptor B2. (1015 aa)
CACNB2GuKc domain-containing protein. (586 aa)
KCNIP2Uncharacterized protein. (286 aa)
ENSNLEP00000043731Uncharacterized protein. (166 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (22%) [HD]