STRINGSTRING
DBH DBH CCDC142 CCDC142 EDN1 EDN1 MMP2 MMP2 FOXJ2 FOXJ2 ADAMTS1 ADAMTS1 RBM10 RBM10 CALCRL CALCRL ADIPOQ ADIPOQ HPGD HPGD MMP9 MMP9 GNAI2 GNAI2 IGFBP5 IGFBP5 MFN2 MFN2 SOD2 SOD2 TERT TERT PRKG1 PRKG1 PTEN PTEN CNN1 CNN1 FGF9 FGF9 JUN JUN GNA13 GNA13 ERN1 ERN1 PDGFB PDGFB PDCD4 PDCD4 TGFB3 TGFB3 NR4A3 NR4A3 HTR1B HTR1B CDKN1B CDKN1B GPER1 GPER1 BMPR1A BMPR1A DNMT1 DNMT1 GNA12 GNA12 LDLRAP1 LDLRAP1 TPM1 TPM1 IL10 IL10 MEF2C MEF2C ENSNLEP00000036074 ENSNLEP00000036074 FRS2 FRS2 MEF2D MEF2D PPARG PPARG NF1 NF1 P2RY6 P2RY6 XBP1 XBP1 IGF1 IGF1 MYOCD MYOCD EFEMP2 EFEMP2 TNF TNF MAP3K5 MAP3K5 SRC SRC DDR2 DDR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DBHDopamine beta-hydroxylase. (611 aa)
CCDC142Coiled-coil domain containing 142. (749 aa)
EDN1Endothelin 1. (211 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
FOXJ2Forkhead box J2. (573 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
RBM10RNA binding motif protein 10. (908 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
GNAI2G protein subunit alpha i2. (355 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (722 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (983 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (304 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
GNA13G protein subunit alpha 13. (373 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
PDCD4Programmed cell death 4. (470 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (636 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
CDKN1BUncharacterized protein. (204 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1646 aa)
GNA12G protein subunit alpha 12. (381 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (299 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
IL10Interleukin 10. (178 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSNLEP00000036074Uncharacterized protein. (393 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NF1Neurofibromin 1. (2839 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
XBP1BZIP domain-containing protein. (376 aa)
IGF1IlGF domain-containing protein. (196 aa)
MYOCDMyocardin. (986 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (456 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
SRCTyrosine-protein kinase. (537 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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