STRINGSTRING
CACNB2 CACNB2 NTSR1 NTSR1 CACNG5 CACNG5 HTT HTT NOS1 NOS1 HCN2 HCN2 CACNB1 CACNB1 EDN1 EDN1 G1QJ30_NOMLE G1QJ30_NOMLE FKBP1B FKBP1B SHANK3 SHANK3 CBARP CBARP JPH1 JPH1 GALR2 GALR2 JSRP1 JSRP1 AMIGO1 AMIGO1 CRACR2A CRACR2A HPCA HPCA GEM GEM AKAP6 AKAP6 ACTN2 ACTN2 KCNRG KCNRG IFNGR2 IFNGR2 CDK5 CDK5 RRAD RRAD STAC STAC ABCC9 ABCC9 CASQ2 CASQ2 TREM2 TREM2 HRC HRC DAPK1 DAPK1 NLGN1 NLGN1 EDNRA EDNRA SHANK1 SHANK1 CNIH2 CNIH2 KLHL24 KLHL24 CACNG7 CACNG7 CACNG8 CACNG8 CABP4 CABP4 CABP2 CABP2 PRRT1 PRRT1 JPH2 JPH2 GAL GAL KCNS1 KCNS1 MMP9 MMP9 KCNG1 KCNG1 SLMAP SLMAP FGF14 FGF14 CACNA1F CACNA1F ANTKMT ANTKMT GRP GRP DRD4 DRD4 R3HDM1 R3HDM1 RASGRF1 RASGRF1 RELN RELN NETO1 NETO1 NLGN2 NLGN2 FGF11 FGF11 REM1 REM1 PKD2 PKD2 LRRC38 LRRC38 CTSS CTSS SHISA9 SHISA9 SHISA6 SHISA6 RNF207 RNF207 PLCG2 PLCG2 HAP1 HAP1 CACNG3 CACNG3 EPO EPO HCN3 HCN3 ANK3 ANK3 LRRC55 LRRC55 CRHBP CRHBP RASGRF2 RASGRF2 FMR1 FMR1 CASQ1 CASQ1 HPCAL1 HPCAL1 HCN4 HCN4 AKAP7 AKAP7 CACNG2 CACNG2 LRRC52 LRRC52 REM2 REM2 CACNA2D1 CACNA2D1 SRI SRI JPH4 JPH4 GSTO1 GSTO1 EHD3 EHD3 PPP3CC PPP3CC NIPSNAP2 NIPSNAP2 NETO2 NETO2 PTK2B PTK2B ANK2 ANK2 STAC3 STAC3 MINK1 MINK1 KCNC1 KCNC1 CACNB3 CACNB3 PIRT PIRT AMIGO3 AMIGO3 KCNA1 KCNA1 KCNK3 KCNK3 AKAP5 AKAP5 NOS1AP NOS1AP PINK1 PINK1 TRDN TRDN ATPSCKMT ATPSCKMT ASPH ASPH ENSNLEP00000024944 ENSNLEP00000024944 PRKACA PRKACA ENSNLEP00000025820 ENSNLEP00000025820 DRD3 DRD3 GSG1L GSG1L HCN1 HCN1 PPP3R1 PPP3R1 PPP3CB PPP3CB UBQLN1 UBQLN1 KCNE4 KCNE4 PDE4B PDE4B PLN PLN PDE4D PDE4D ENSNLEP00000028440 ENSNLEP00000028440 CABP1 CABP1 DLG1 DLG1 MTNR1B MTNR1B STIM1 STIM1 SLC6A9 SLC6A9 CACNB4 CACNB4 DRD2 DRD2 CALM1 CALM1 FGF12 FGF12 STOM STOM ENSNLEP00000031088 ENSNLEP00000031088 DLG4 DLG4 GNB5 GNB5 CNIH3 CNIH3 CRH CRH PPP3CA PPP3CA ENSNLEP00000031915 ENSNLEP00000031915 CAV1 CAV1 LOC101179053 LOC101179053 CRBN CRBN KCNE3 KCNE3 MAPK8IP2 MAPK8IP2 DMD DMD MEF2C MEF2C HOMER1 HOMER1 SELENON SELENON ENSNLEP00000035652 ENSNLEP00000035652 CACNG4 CACNG4 KCNAB1 KCNAB1 KCNE2 KCNE2 PLA2G6 PLA2G6 ENSNLEP00000036861 ENSNLEP00000036861 ENSNLEP00000037205 ENSNLEP00000037205 NRXN1 NRXN1 NLGN3 NLGN3 R3HDM2 R3HDM2 CAMK2D CAMK2D STIM2 STIM2 P2RY6 P2RY6 ENSNLEP00000041070 ENSNLEP00000041070 GSG1 GSG1 ABCC8 ABCC8 ENSNLEP00000041886 ENSNLEP00000041886 EPHB2 EPHB2 LOC100590514 LOC100590514 CLIC2 CLIC2 KCNIP2 KCNIP2 KCNC2 KCNC2 ENSNLEP00000044241 ENSNLEP00000044241 OPRM1 OPRM1 SUMO1 SUMO1 CABP5 CABP5 LOC100606903 LOC100606903
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNB2GuKc domain-containing protein. (586 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
HTTHuntingtin. (3048 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
HCN2Cyclic nucleotide-binding domain-containing protein. (510 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (586 aa)
EDN1Endothelin 1. (211 aa)
G1QJ30_NOMLEUncharacterized protein. (363 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1521 aa)
CBARPUncharacterized protein. (667 aa)
JPH1Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (661 aa)
GALR2Galanin receptor 2; Belongs to the G-protein coupled receptor 1 family. (387 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (334 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
CRACR2ACalcium release activated channel regulator 2A. (721 aa)
HPCAHippocalcin. (193 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
AKAP6A-kinase anchoring protein 6. (2238 aa)
ACTN2Actinin alpha 2. (854 aa)
KCNRGBTB domain-containing protein. (214 aa)
IFNGR2Interferon gamma receptor 2. (314 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
STACSH3 and cysteine rich domain. (402 aa)
ABCC9ATP binding cassette subfamily C member 9. (1567 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (373 aa)
TREM2Ig-like domain-containing protein. (222 aa)
HRCHistidine rich calcium binding protein. (696 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
NLGN1Neuroligin 1. (823 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SHANK1Uncharacterized protein. (1415 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (133 aa)
KLHL24Kelch like family member 24. (600 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (271 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (424 aa)
CABP4Calcium binding protein 4. (275 aa)
CABP2Uncharacterized protein. (226 aa)
PRRT1Proline rich transmembrane protein 1. (263 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (680 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
KCNS1Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (529 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
KCNG1Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family. (513 aa)
SLMAPSarcolemma associated protein. (828 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
ANTKMTAdenine nucleotide translocase lysine methyltransferase. (235 aa)
GRPGastrin releasing peptide. (148 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (386 aa)
R3HDM1R3H domain containing 1. (1100 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1243 aa)
RELNReelin. (3460 aa)
NETO1Neuropilin and tolloid like 1. (525 aa)
NLGN2Neuroligin 2. (768 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (921 aa)
LRRC38Leucine rich repeat containing 38. (294 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
SHISA9Uncharacterized protein. (236 aa)
SHISA6Shisa family member 6. (553 aa)
RNF207Ring finger protein 207. (634 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1218 aa)
HAP1Huntingtin associated protein 1. (624 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (729 aa)
ANK3Ankyrin 3. (4058 aa)
LRRC55Leucine rich repeat containing 55. (341 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1232 aa)
FMR1Fragile X mental retardation 1. (632 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (121 aa)
HPCAL1Hippocalcin like 1. (193 aa)
HCN4Cyclic nucleotide-binding domain-containing protein. (754 aa)
AKAP7A-kinase anchoring protein 7. (348 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
LRRC52Leucine rich repeat containing 52. (313 aa)
REM2RRAD and GEM like GTPase 2. (340 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1071 aa)
SRISorcin. (221 aa)
JPH4Junctophilin 4. (613 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (478 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
NIPSNAP2Nipsnap homolog 2. (263 aa)
NETO2Neuropilin and tolloid like 2. (517 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
ANK2Ankyrin 2. (3957 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
MINK1Misshapen like kinase 1. (1259 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (444 aa)
PIRTPhosphoinositide interacting regulator of transient receptor potential channels. (137 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (504 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
KCNK3Ion_trans_2 domain-containing protein. (271 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
NOS1APPID domain-containing protein. (485 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
TRDNTriadin. (728 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (232 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
ENSNLEP00000024944Uncharacterized protein. (179 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
ENSNLEP00000025820Rad60-SLD domain-containing protein. (80 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
GSG1LUncharacterized protein. (162 aa)
HCN1Cyclic nucleotide-binding domain-containing protein. (628 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
UBQLN1Ubiquilin 1. (589 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
PDE4BPhosphodiesterase. (736 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PDE4DPhosphodiesterase. (748 aa)
ENSNLEP00000028440Uncharacterized protein. (95 aa)
CABP1Uncharacterized protein. (304 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa)
MTNR1BUncharacterized protein. (89 aa)
STIM1Stromal interaction molecule 1. (818 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (649 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (502 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (445 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
STOMPHB domain-containing protein. (288 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (746 aa)
GNB5G protein subunit beta 5. (357 aa)
CNIH3Cornichon family AMPA receptor auxiliary protein 3. (159 aa)
CRHCorticotropin releasing hormone. (196 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSNLEP00000031915Ubiquitin-like domain-containing protein. (93 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
LOC101179053Small ubiquitin-related modifier. (94 aa)
CRBNCereblon. (490 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (101 aa)
MAPK8IP2PID domain-containing protein. (178 aa)
DMDDystrophin. (3685 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
HOMER1Homer scaffold protein 1. (377 aa)
SELENONUncharacterized protein. (66 aa)
ENSNLEP00000035652Uncharacterized protein; Belongs to the calmodulin family. (123 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (419 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
PLA2G6Phospholipase A2 group VI. (805 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
ENSNLEP00000037205Uncharacterized protein. (322 aa)
NRXN1Neurexin 1. (1547 aa)
NLGN3Neuroligin 3. (912 aa)
R3HDM2R3H domain containing 2. (1033 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
STIM2Stromal interaction molecule 2. (841 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
ENSNLEP00000041070Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (703 aa)
GSG1Germ cell associated 1. (340 aa)
ABCC8ATP binding cassette subfamily C member 8. (1569 aa)
ENSNLEP00000041886Ion_trans domain-containing protein; Belongs to the potassium channel family. (359 aa)
EPHB2EPH receptor B2. (1015 aa)
LOC100590514Uncharacterized protein. (130 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (243 aa)
KCNIP2Uncharacterized protein. (286 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
ENSNLEP00000044241PHB domain-containing protein. (282 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
SUMO1Small ubiquitin-related modifier. (88 aa)
CABP5Calcium binding protein 5. (173 aa)
LOC100606903Uncharacterized protein; Belongs to the GST superfamily. (236 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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