STRINGSTRING
SPAM1 SPAM1 LOC100607540 LOC100607540 DUS3L DUS3L DUS1L DUS1L HAO1 HAO1 RSAD2 RSAD2 QPRT QPRT NAGA NAGA ALAD ALAD GALC GALC ALDOB ALDOB RSAD1 RSAD1 ENSNLEP00000024528 ENSNLEP00000024528 ENSNLEP00000025014 ENSNLEP00000025014 LOC100581475-2 LOC100581475-2 NANS NANS ENSNLEP00000026287 ENSNLEP00000026287 LOC100580366 LOC100580366 HMGCL HMGCL LIAS LIAS ENSNLEP00000031521 ENSNLEP00000031521 TALDO1 TALDO1 DHODH DHODH NPL NPL IMPDH1 IMPDH1 LOC100585501 LOC100585501 LOC100579692 LOC100579692 NAPRT NAPRT ENSNLEP00000039208 ENSNLEP00000039208 RPE RPE MOCS1 MOCS1 HYAL4 HYAL4 DPYD DPYD NAMPT NAMPT DUS4L DUS4L HYAL2 HYAL2 HYAL1 HYAL1 HYAL3 HYAL3 IMPDH2 IMPDH2 PC PC HAO2 HAO2 DUS2 DUS2 TPI1 TPI1 ALDOC ALDOC GMPR GMPR UMPS UMPS GLA GLA DERA DERA ENSNLEP00000046132 ENSNLEP00000046132 ENSNLEP00000045395 ENSNLEP00000045395 HMGCLL1 HMGCLL1 ENSNLEP00000040993 ENSNLEP00000040993 GMPR2 GMPR2 LOC100581732 LOC100581732 IMPDH IMPDH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPAM1Hyaluronidase. (511 aa)
LOC100607540Flavodoxin-like domain-containing protein. (732 aa)
DUS3LtRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (649 aa)
DUS1LDihydrouridine synthase 1 like. (440 aa)
HAO1Hydroxyacid oxidase 1. (370 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (361 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (291 aa)
NAGAAlpha-galactosidase. (411 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
GALCGalactosylceramidase. (685 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
RSAD1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa)
ENSNLEP00000024528Uncharacterized protein. (493 aa)
ENSNLEP00000025014Triosephosphate isomerase. (235 aa)
LOC100581475-2Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
NANSAFP-like domain-containing protein. (317 aa)
ENSNLEP00000026287Uncharacterized protein. (151 aa)
LOC100580366Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (447 aa)
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase. (311 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
ENSNLEP00000031521Uncharacterized protein. (491 aa)
TALDO1Uncharacterized protein. (310 aa)
DHODHDihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
NPLN-acetylneuraminate pyruvate lyase; Belongs to the DapA family. (320 aa)
IMPDH1CBS domain-containing protein. (487 aa)
LOC100585501IMPDH domain-containing protein. (529 aa)
LOC100579692Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (437 aa)
NAPRTNicotinate phosphoribosyltransferase. (602 aa)
ENSNLEP00000039208Uncharacterized protein. (322 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (233 aa)
MOCS1Molybdenum cofactor synthesis 1. (636 aa)
HYAL4Hyaluronidase. (481 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (475 aa)
DUS4LtRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (317 aa)
HYAL2Hyaluronidase. (473 aa)
HYAL1Hyaluronidase. (435 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
PCUncharacterized protein. (1094 aa)
HAO2Hydroxyacid oxidase 2. (364 aa)
DUS2Dihydrouridine synthase 2. (490 aa)
TPI1Triosephosphate isomerase. (286 aa)
ALDOCUncharacterized protein. (282 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
UMPSUridine monophosphate synthetase. (481 aa)
GLAAlpha-galactosidase. (429 aa)
DERADeoxyribose-phosphate aldolase. (311 aa)
ENSNLEP00000046132Elp3 domain-containing protein. (343 aa)
ENSNLEP00000045395Triosephosphate isomerase. (200 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (362 aa)
ENSNLEP00000040993Uncharacterized protein. (521 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (395 aa)
LOC100581732Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (581 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (516 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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