node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRAF | PRKCA | ENSNLEP00000002720 | ENSNLEP00000000331 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.918 |
BRAF | PRKCB | ENSNLEP00000002720 | ENSNLEP00000043873 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.914 |
BRAF | PRKCD | ENSNLEP00000002720 | ENSNLEP00000008796 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.910 |
BRAF | PRKCE | ENSNLEP00000002720 | ENSNLEP00000020530 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] | 0.948 |
BRAF | PRKCG | ENSNLEP00000002720 | ENSNLEP00000007555 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.936 |
BRAF | PRKCH | ENSNLEP00000002720 | ENSNLEP00000029933 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | 0.925 |
BRAF | PRKCQ | ENSNLEP00000002720 | ENSNLEP00000014346 | B-Raf proto-oncogene, serine/threonine kinase. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.910 |
BRAF | RAF1 | ENSNLEP00000002720 | ENSNLEP00000024343 | B-Raf proto-oncogene, serine/threonine kinase. | Raf-1 proto-oncogene, serine/threonine kinase. | 0.998 |
PRKCA | BRAF | ENSNLEP00000000331 | ENSNLEP00000002720 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | B-Raf proto-oncogene, serine/threonine kinase. | 0.918 |
PRKCA | PRKCB | ENSNLEP00000000331 | ENSNLEP00000043873 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.953 |
PRKCA | PRKCD | ENSNLEP00000000331 | ENSNLEP00000008796 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.959 |
PRKCA | PRKCE | ENSNLEP00000000331 | ENSNLEP00000020530 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] | 0.543 |
PRKCA | PRKCG | ENSNLEP00000000331 | ENSNLEP00000007555 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.986 |
PRKCA | PRKCH | ENSNLEP00000000331 | ENSNLEP00000029933 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | 0.420 |
PRKCA | PRKCI | ENSNLEP00000000331 | ENSNLEP00000023343 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.460 |
PRKCA | PRKCQ | ENSNLEP00000000331 | ENSNLEP00000014346 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.429 |
PRKCA | PRKCZ | ENSNLEP00000000331 | ENSNLEP00000000211 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Protein kinase C zeta. | 0.467 |
PRKCA | PRKD1 | ENSNLEP00000000331 | ENSNLEP00000018928 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.906 |
PRKCA | PRKD3 | ENSNLEP00000000331 | ENSNLEP00000019739 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.902 |
PRKCA | RAF1 | ENSNLEP00000000331 | ENSNLEP00000024343 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Raf-1 proto-oncogene, serine/threonine kinase. | 0.916 |