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UNC13A UNC13A CHN1 CHN1 CDC42BPA CDC42BPA RASSF1 RASSF1 PDZD8 PDZD8 VAV1 VAV1 ARHGEF2 ARHGEF2 ARAF ARAF LOC100579595 LOC100579595 DGKA DGKA RAF1 RAF1 PRKCI PRKCI PRKCZ PRKCZ PRKCA PRKCA PRKCH PRKCH RASGRP3 RASGRP3 KSR2 KSR2 ARHGAP45 ARHGAP45 RACGAP1 RACGAP1 TNS2 TNS2 STAC3 STAC3 PRKCE PRKCE RASGRP4 RASGRP4 DGKB DGKB PRKD3 PRKD3 PRKD1 PRKD1 MYO9A MYO9A PRKCQ PRKCQ KSR1 KSR1 BRAF BRAF PRKD2 PRKD2 LOC100582721 LOC100582721 ARHGEF28 ARHGEF28 STAC STAC CDC42BPG CDC42BPG PRKCG PRKCG DGKG DGKG PRKCD PRKCD DGKK DGKK DGKD DGKD RASSF5 RASSF5 G1QJ30_NOMLE G1QJ30_NOMLE DEF8 DEF8 DGKH DGKH ROCK2 ROCK2 RASGRP2 RASGRP2 CIT CIT CHN2 CHN2 CDC42BPB CDC42BPB UNC13B UNC13B ROCK1 ROCK1 PRKCB PRKCB GMIP GMIP NSMCE1 NSMCE1 RASGRP1 RASGRP1 AKAP13 AKAP13 ARHGAP29 ARHGAP29
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UNC13AUnc-13 homolog A. (1460 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
CDC42BPANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1737 aa)
RASSF1Ras association domain family member 1. (304 aa)
PDZD8Uncharacterized protein. (1154 aa)
VAV1Uncharacterized protein. (739 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
ARAFUncharacterized protein. (664 aa)
LOC100579595Uncharacterized protein. (1038 aa)
DGKADiacylglycerol kinase. (743 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
PRKCZProtein kinase C zeta. (507 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
RASGRP3RAS guanyl releasing protein 3. (690 aa)
KSR2Kinase suppressor of ras 2. (950 aa)
ARHGAP45Uncharacterized protein. (653 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
TNS2Tensin 2. (1361 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RASGRP4RAS guanyl releasing protein 4. (673 aa)
DGKBDiacylglycerol kinase. (804 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2548 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
KSR1Kinase suppressor of ras 1. (831 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
PRKD2Uncharacterized protein. (716 aa)
LOC100582721General transcription factor IIH subunit. (395 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1731 aa)
STACSH3 and cysteine rich domain. (402 aa)
CDC42BPGCDC42 binding protein kinase gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
DGKGDiacylglycerol kinase. (791 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
DGKKDiacylglycerol kinase. (1534 aa)
DGKDDiacylglycerol kinase. (1185 aa)
RASSF5Ras association domain family member 5. (418 aa)
G1QJ30_NOMLEUncharacterized protein. (363 aa)
DEF8Differentially expressed in FDCP 8 homolog. (512 aa)
DGKHDiacylglycerol kinase. (1188 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
RASGRP2RAS guanyl releasing protein 2. (610 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2048 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1699 aa)
UNC13BUncharacterized protein. (4218 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GMIPUncharacterized protein. (867 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (266 aa)
RASGRP1RAS guanyl releasing protein 1. (785 aa)
AKAP13A-kinase anchoring protein 13. (2761 aa)
ARHGAP29Rho GTPase activating protein 29. (1265 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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