STRINGSTRING
EREG EREG PRKCA PRKCA KRAS KRAS ERBB4 ERBB4 PRKCD PRKCD BTC BTC HRAS HRAS NRG2 NRG2 HBEGF HBEGF SHC1 SHC1 SOS1 SOS1 EGF EGF PRKCE PRKCE ERAS ERAS EGFR EGFR ENSNLEP00000039370 ENSNLEP00000039370 NRAS NRAS GRB2 GRB2 PTPN12 PTPN12 NRG4 NRG4 NRG1 NRG1 ENSNLEP00000046563 ENSNLEP00000046563 NRG3 NRG3 ERBB3 ERBB3 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EREGEpiregulin. (169 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
BTCBetacellulin. (178 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NRG2Uncharacterized protein. (597 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
SHC1SHC adaptor protein 1. (542 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ERASES cell expressed Ras. (233 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (755 aa)
NRG4Neuregulin 4. (117 aa)
NRG1Neuregulin 1. (713 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
NRG3Neuregulin 3. (720 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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