STRINGSTRING
CDC25A CDC25A TFDP1 TFDP1 RBL2 RBL2 CDC6 CDC6 TOP2A TOP2A CDK3 CDK3 HDAC1 HDAC1 E2F5 E2F5 CCNE2 CCNE2 E2F4 E2F4 MYC MYC RBL1 RBL1 TESMIN TESMIN CCNE1 CCNE1 PCNA PCNA CCNA2 CCNA2 E2F1 E2F1 LIN37 LIN37 DYRK1B DYRK1B MAX MAX CCNA1 CCNA1 LIN52 LIN52 DYRK1A DYRK1A LOC100584595 LOC100584595 ENSNLEP00000027752 ENSNLEP00000027752 ENSNLEP00000027951 ENSNLEP00000027951 CDK1 CDK1 CDK2 CDK2 ENSNLEP00000033819 ENSNLEP00000033819 LIN9 LIN9 ENSNLEP00000037083 ENSNLEP00000037083 MYBL2 MYBL2 TFDP2 TFDP2 LIN54 LIN54 ENSNLEP00000043421 ENSNLEP00000043421 ENSNLEP00000046336 ENSNLEP00000046336
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC25ACell division cycle 25A. (524 aa)
TFDP1Transcription factor. (395 aa)
RBL2RB transcriptional corepressor like 2. (1138 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1502 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (270 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
E2F5E2F transcription factor 5. (346 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
E2F4E2F transcription factor 4. (397 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
TESMINTestis expressed metallothionein like protein. (472 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (402 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
E2F1E2F transcription factor 1. (391 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
DYRK1BProtein kinase domain-containing protein. (528 aa)
MAXMYC associated factor X. (160 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (758 aa)
LOC100584595WD_REPEATS_REGION domain-containing protein. (408 aa)
ENSNLEP00000027752Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (243 aa)
ENSNLEP00000027951CAF1C_H4-bd domain-containing protein. (97 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (311 aa)
ENSNLEP00000033819Uncharacterized protein. (375 aa)
LIN9Lin-9 DREAM MuvB core complex component. (615 aa)
ENSNLEP00000037083WD_REPEATS_REGION domain-containing protein. (413 aa)
MYBL2MYB proto-oncogene like 2. (701 aa)
TFDP2Transcription factor. (403 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
ENSNLEP00000043421Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (393 aa)
ENSNLEP00000046336Transcription factor. (371 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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