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| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (328 aa) |
| | GSR | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (522 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | SETBP1 | SET binding protein 1. (1596 aa) |
| | ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (342 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (539 aa) |
| | PFAS | Uncharacterized protein. (1108 aa) |
| | AK5 | Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa) |
| | PAPOLG | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (429 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (545 aa) |
| | NME3 | Nucleoside diphosphate kinase. (169 aa) |
| | NME4 | Nucleoside diphosphate kinase. (187 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (188 aa) |
| | CMPK1-2 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa) |
| | TXNDC2 | Thioredoxin domain-containing protein. (440 aa) |
| | TYMS | Thymidylat_synt domain-containing protein. (173 aa) |
| | QRICH1 | Glutamine rich 1. (777 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | DALRD3 | DALR_1 domain-containing protein. (376 aa) |
| | CEP44 | Centrosomal protein 44. (399 aa) |
| | TXNRD1 | Thioredoxin reductase 1. (647 aa) |
| | SAMHD1 | Uncharacterized protein. (626 aa) |
| | DUT | Deoxyuridine triphosphatase. (237 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | ADAL | Adenosine deaminase like. (355 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa) |
| | IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough. (489 aa) |
| | GART | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa) |
| | DPYS | Dihydropyrimidinase. (519 aa) |
| | GMPS | Guanine monophosphate synthase. (693 aa) |
| | CDADC1 | Cytidine and dCMP deaminase domain containing 1. (497 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2200 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (879 aa) |
| | NME8 | NME/NM23 family member 8. (588 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa) |
| | NT5C1B | Uncharacterized protein. (609 aa) |
| | NRSN1 | Neurensin 1. (195 aa) |
| | TXNRD3 | Thioredoxin reductase 3. (561 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | UPP2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (363 aa) |
| | UMPS | Uridine monophosphate synthetase. (481 aa) |
| | AK7 | Adenylate kinase 7. (689 aa) |
| | NT5C | 5', 3'-nucleotidase, cytosolic. (201 aa) |
| | DNPH1 | Uncharacterized protein. (121 aa) |
| | AK9 | Adenylate kinase 9. (1911 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | UCK1 | Uridine-cytidine kinase 1. (281 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (450 aa) |
| | NT5DC1 | 5'-nucleotidase domain containing 1. (411 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (502 aa) |
| | G1RT41_NOMLE | Uncharacterized protein. (154 aa) |
| | GLRX | Glutaredoxin. (106 aa) |
| | G1RWH5_NOMLE | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (356 aa) |
| | UCK2 | Uridine-cytidine kinase 2. (228 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | ADSS1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | NUDT13 | Nudix hydrolase 13. (352 aa) |
| | PRTFDC1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (209 aa) |
| | ENKUR | Enkurin, TRPC channel interacting protein. (256 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | GLRX2 | Glutaredoxin domain-containing protein. (164 aa) |
| | SMIM3 | Small integral membrane protein 3. (60 aa) |
| | LOC100596611 | Uncharacterized protein. (233 aa) |
| | IPO13 | Importin 13. (926 aa) |
| | NUDT6 | Nudix hydrolase 6. (316 aa) |
| | ENSNLEP00000024528 | Uncharacterized protein. (493 aa) |
| | NME9 | NME/NM23 family member 9; Belongs to the NDK family. (330 aa) |
| | ENSNLEP00000026588 | GMP_synt_C domain-containing protein. (233 aa) |
| | NT5C2 | 5'-nucleotidase, cytosolic II. (584 aa) |
| | ADK | Adenosine kinase. (362 aa) |
| | NUDT16 | Nudix hydrolase 16. (227 aa) |
| | TXNDC8 | Thioredoxin domain-containing protein. (108 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (471 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (239 aa) |
| | ENSNLEP00000029241 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (190 aa) |
| | DCTD | dCMP deaminase. (178 aa) |
| | AK4-2 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (209 aa) |
| | ADA | Adenosine deaminase. (405 aa) |
| | ENSNLEP00000032071 | Uncharacterized protein. (140 aa) |
| | DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa) |
| | SLC25A42 | Solute carrier family 25 member 42; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa) |
| | ENSNLEP00000033213 | Uncharacterized protein. (79 aa) |
| | PAICS | AIRC domain-containing protein. (451 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (484 aa) |
| | NUDT9 | Nudix hydrolase 9. (349 aa) |
| | ENSNLEP00000029534 | AIRC domain-containing protein. (373 aa) |
| | IMPDH1 | CBS domain-containing protein. (487 aa) |
| | DCK | dNK domain-containing protein. (317 aa) |
| | LOC100595437 | Thioredoxin domain-containing protein. (105 aa) |
| | LOC100585501 | IMPDH domain-containing protein. (529 aa) |
| | ENSNLEP00000036501 | Uncharacterized protein. (326 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (458 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (355 aa) |
| | IQCJ | IQ motif containing J. (158 aa) |
| | ENSNLEP00000037515 | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (448 aa) |
| | ENSNLEP00000038989 | Uncharacterized protein. (64 aa) |
| | NUDT15 | Nudix hydrolase 15. (164 aa) |
| | IMPDH | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (516 aa) |
| | LOC100581732 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (581 aa) |
| | ENSNLEP00000040595 | Nudix hydrolase domain-containing protein. (192 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (395 aa) |
| | ENSNLEP00000040993 | Uncharacterized protein. (521 aa) |
| | ENSNLEP00000041001 | dUTPase domain-containing protein. (155 aa) |
| | NUDT18 | Nudix hydrolase 18; Belongs to the Nudix hydrolase family. (323 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa) |
| | XDH | Xanthine dehydrogenase. (1271 aa) |
| | ENTPD7 | Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa) |
| | NUDT5 | Nudix hydrolase 5; Belongs to the Nudix hydrolase family. (232 aa) |
| | NUDT1 | Nudix hydrolase 1; Belongs to the Nudix hydrolase family. (190 aa) |
| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | LOC100596451 | Uncharacterized protein. (222 aa) |
| | ENSNLEP00000044316 | Uncharacterized protein; Belongs to the adenylate kinase family. (134 aa) |
| | ENSNLEP00000044481 | Uncharacterized protein. (241 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (617 aa) |
| | UPB1 | Beta-ureidopropionase 1. (384 aa) |
| | ENSNLEP00000045608 | Uncharacterized protein. (362 aa) |
| | CMPK2 | Thymidylate_kin domain-containing protein. (379 aa) |
| | ENSNLEP00000046431 | Thioredoxin; Belongs to the thioredoxin family. (101 aa) |
| | LOC100582337 | Nucleoside diphosphate kinase. (147 aa) |
| | TXN | Thioredoxin domain-containing protein. (97 aa) |
| | NME1-NME2 | Nucleoside diphosphate kinase. (292 aa) |
| | GUK1 | Guanylate kinase-like domain-containing protein. (272 aa) |
| | PUDP | Uncharacterized protein. (170 aa) |
| | TK2 | Thymidine kinase 2. (296 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa) |
| | ENSNLEP00000049027 | Thioredoxin domain-containing protein. (90 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa) |
| | DGUOK | Deoxyguanosine kinase. (277 aa) |
| | ENSNLEP00000030488 | Glutaredoxin domain-containing protein. (120 aa) |
| | ENSNLEP00000030516 | Thymidine kinase. (240 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa) |
| | ENSNLEP00000030795 | Thymidylate_kin domain-containing protein. (224 aa) |
| | ENSNLEP00000031212 | Uncharacterized protein. (300 aa) |
| | ENSNLEP00000031521 | Uncharacterized protein. (491 aa) |
