STRINGSTRING
ENSNLEP00000049227 ENSNLEP00000049227 ENSNLEP00000047589 ENSNLEP00000047589 FOS FOS S100B S100B MAPK8 MAPK8 TAB3 TAB3 RPS27A RPS27A DUSP6 DUSP6 ENSNLEP00000043688 ENSNLEP00000043688 TONSL TONSL NKIRAS2 NKIRAS2 NLRX1 NLRX1 ENSNLEP00000042252 ENSNLEP00000042252 ENSNLEP00000042204 ENSNLEP00000042204 MAP2K3 MAP2K3 ENSNLEP00000041707 ENSNLEP00000041707 PPP2CA PPP2CA CASP8 CASP8 FNBP4 FNBP4 ENSNLEP00000039422 ENSNLEP00000039422 ENSNLEP00000039390 ENSNLEP00000039390 ENSNLEP00000038869 ENSNLEP00000038869 ENSNLEP00000038579 ENSNLEP00000038579 BIRC2 BIRC2 CREB5 CREB5 NKIRAS1 NKIRAS1 ENSNLEP00000037583 ENSNLEP00000037583 ENSNLEP00000036881 ENSNLEP00000036881 PPP2R1A PPP2R1A RELA RELA MAP2K1 MAP2K1 LOC100605369 LOC100605369 TIFA TIFA ENSNLEP00000034619 ENSNLEP00000034619 MEF2C MEF2C ATF2 ATF2 ENSNLEP00000033428 ENSNLEP00000033428 PPP2R1B PPP2R1B ENSNLEP00000032011 ENSNLEP00000032011 FOSL2 FOSL2 MAPK9 MAPK9 FBXW11 FBXW11 CREM CREM ENSNLEP00000028612 ENSNLEP00000028612 VRK3 VRK3 RPS6KA5 RPS6KA5 ENSNLEP00000027584 ENSNLEP00000027584 ENSNLEP00000027432 ENSNLEP00000027432 NLRP13 NLRP13 MAPK1 MAPK1 N4BP1 N4BP1 CCDC71L CCDC71L S100A12 S100A12 APP APP MAP2K4 MAP2K4 MAPK10 MAPK10 DUSP7 DUSP7 CHUK CHUK TLR4 TLR4 MAPK11 MAPK11 MEF2A MEF2A ENSNLEP00000024736 ENSNLEP00000024736 MAP3K20 MAP3K20 MAPK14 MAPK14 USP14 USP14 RPS27A-2 RPS27A-2 TRAF6 TRAF6 ATF1 ATF1 SAA1 SAA1 SAA2 SAA2 LOC100596548 LOC100596548 PPP4R4 PPP4R4 MAP3K8 MAP3K8 TBK1 TBK1 DUSP4 DUSP4 LRRC74A LRRC74A ALPK1 ALPK1 TRAF3 TRAF3 KHNYN KHNYN RIPK3 RIPK3 TAB2 TAB2 TAB1 TAB1 NOD1 NOD1 NFKB2 NFKB2 BTRC BTRC JUN JUN G1RWX7_NOMLE G1RWX7_NOMLE IKBKG IKBKG LRRC45 LRRC45 MAP3K7 MAP3K7 NFKB1 NFKB1 TICAM1 TICAM1 LRRC71 LRRC71 IKBKB IKBKB PPP2CB PPP2CB TICAM2 TICAM2 RPS6KA2 RPS6KA2 RIPK1 RIPK1 LRRC14 LRRC14 NLRP9 NLRP9 FADD FADD PTPN11 PTPN11 TNIP2 TNIP2 IKBKE IKBKE HMGB1 HMGB1 MAPKAPK2 MAPKAPK2 NOD2 NOD2 MAP2K7 MAP2K7 TANK TANK MAPK3 MAPK3 RIPK2 RIPK2 G1QNP0_NOMLE G1QNP0_NOMLE SARM1 SARM1 TRAF5 TRAF5 MAP2K6 MAP2K6 NLRC5 NLRC5 ELK1 ELK1 CUL1 CUL1 NFKBIA NFKBIA IRAK2 IRAK2 NAIP NAIP VWC2 VWC2 PPP2R5D PPP2R5D LRRC34 LRRC34 LRRC31 LRRC31 IRF3 IRF3 UBE2N UBE2N DUSP3 DUSP3 KXD1 KXD1 AGER AGER PPP4R1 PPP4R1 MAPKAPK3 MAPKAPK3 CREB1 CREB1 BIRC3 BIRC3 LRRC74B LRRC74B SKP1 SKP1 NLRP6 NLRP6 IRF7 IRF7 RELCH RELCH TRAF2 TRAF2 MAPK7 MAPK7 CD14 CD14 RPS6KA1 RPS6KA1 RPS6KA3 RPS6KA3 BIRC7 BIRC7 LY96 LY96 ENSNLEP00000029811 ENSNLEP00000029811
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSNLEP00000049227Uncharacterized protein. (122 aa)
ENSNLEP00000047589Uncharacterized protein. (175 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
S100BS_100 domain-containing protein; Belongs to the S-100 family. (94 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
RPS27AUbiquitin-like domain-containing protein. (161 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
TONSLTonsoku like, DNA repair protein. (1408 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (231 aa)
NLRX1NLR family member X1. (901 aa)
ENSNLEP00000042252Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
ENSNLEP00000042204UBIQUITIN_CONJUGAT_2 domain-containing protein. (131 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (317 aa)
ENSNLEP00000041707UBIQUITIN_CONJUGAT_2 domain-containing protein. (77 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
FNBP4Formin binding protein 4. (1022 aa)
ENSNLEP00000039422Ubiquitin-like domain-containing protein. (136 aa)
ENSNLEP00000039390Protein kinase domain-containing protein. (673 aa)
ENSNLEP00000038869Ubiquitin-like domain-containing protein. (156 aa)
ENSNLEP00000038579Ubiquitin-like domain-containing protein. (104 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (477 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
ENSNLEP00000037583Ubiquitin-like domain-containing protein. (79 aa)
ENSNLEP00000036881Uncharacterized protein. (179 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC100605369Uncharacterized protein. (571 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
ENSNLEP00000034619Ubiquitin-like domain-containing protein. (77 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSNLEP00000033428Protein kinase domain-containing protein. (369 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
ENSNLEP00000032011Uncharacterized protein. (147 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
CREMcAMP responsive element modulator. (344 aa)
ENSNLEP00000028612Uncharacterized protein. (134 aa)
VRK3VRK serine/threonine kinase 3. (474 aa)
RPS6KA5Ribosomal protein S6 kinase. (797 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
ENSNLEP00000027432TNF receptor-associated factor. (488 aa)
NLRP13NLR family pyrin domain containing 13. (930 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
N4BP1NEDD4 binding protein 1. (893 aa)
CCDC71LUncharacterized protein. (293 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (91 aa)
APPAmyloid beta precursor protein. (757 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (468 aa)
RPS27A-2Ubiquitin-like domain-containing protein. (156 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ATF1Activating transcription factor 1. (270 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
LOC100596548Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (417 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (855 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
TBK1TANK binding kinase 1. (729 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
LRRC74ALeucine rich repeat containing 74A. (454 aa)
ALPK1Alpha kinase 1. (1241 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
KHNYNKH and NYN domain containing. (665 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (506 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (305 aa)
G1RWX7_NOMLEANK_REP_REGION domain-containing protein. (182 aa)
IKBKGNEMO domain-containing protein. (173 aa)
LRRC45Leucine rich repeat containing 45. (665 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (691 aa)
LRRC71Leucine rich repeat containing 71. (507 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (692 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
LRRC14Leucine rich repeat containing 14. (476 aa)
NLRP9Uncharacterized protein. (893 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
TNIP2CCHC NOA-type domain-containing protein. (322 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (676 aa)
HMGB1High mobility group box 1. (215 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
G1QNP0_NOMLEProtein kinase domain-containing protein. (234 aa)
SARM1Sterile alpha and TIR motif containing 1. (641 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NLRC5NLR family CARD domain containing 5. (1783 aa)
ELK1ETS transcription factor ELK1. (390 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
NFKBIANFKB inhibitor alpha. (305 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (568 aa)
NAIPNLR family apoptosis inhibitory protein. (1257 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (607 aa)
LRRC34Leucine rich repeat containing 34. (464 aa)
LRRC31Leucine rich repeat containing 31. (552 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (301 aa)
UBE2NUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
KXD1KxDL motif containing 1. (195 aa)
AGERAdvanced glycosylation end-product specific receptor. (404 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (950 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
LRRC74BLeucine rich repeat containing 74B. (392 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
NLRP6Pyrin domain-containing protein. (633 aa)
IRF7Interferon regulatory factor 7. (524 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1219 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
LY96Lymphocyte antigen 96. (160 aa)
ENSNLEP00000029811Uncharacterized protein; Belongs to the SKP1 family. (146 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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