STRINGSTRING
RNF111 RNF111 UBE2M UBE2M IRX2 IRX2 CGN CGN XPO1 XPO1 MTMR4 MTMR4 SERPINE1 SERPINE1 STUB1 STUB1 CBL CBL PARD3B PARD3B NEDD8 NEDD8 ENSNLEP00000031295 ENSNLEP00000031295 TGIF1 TGIF1 ITGB1 ITGB1 CCNT2 CCNT2 SNW1 SNW1 PARD3 PARD3 FKBP1A FKBP1A MAPK1 MAPK1 ENSNLEP00000027025 ENSNLEP00000027025 RBL1 RBL1 ITGB6 ITGB6 USP9X USP9X ENSNLEP00000025225 ENSNLEP00000025225 LDLRAD4 LDLRAD4 SMAD2 SMAD2 F11R F11R LOC100581805 LOC100581805 RPS27A-2 RPS27A-2 RHOA RHOA PPP1CA PPP1CA ZFYVE9 ZFYVE9 CCNT1 CCNT1 SP1 SP1 CDK9 CDK9 USP15 USP15 BAMBI BAMBI MKX MKX ITGB8 ITGB8 TGFB3 TGFB3 LTBP1 LTBP1 COL1A2 COL1A2 PPP1CB PPP1CB ATP1B4 ATP1B4 SMURF2 SMURF2 NCOR1 NCOR1 TGFB2 TGFB2 CDK8 CDK8 LTBP4 LTBP4 PARP1 PARP1 TGFB1 TGFB1 PPM1A PPM1A CCNQ CCNQ ITGA8 ITGA8 YBX1 YBX1 UBE2D1 UBE2D1 FURIN FURIN SMAD4 SMAD4 IRX3 IRX3 ITGB3 ITGB3 PPP1R15A PPP1R15A STAT1 STAT1 ENSNLEP00000034619 ENSNLEP00000034619 JUNB JUNB ENSNLEP00000034935 ENSNLEP00000034935 ITGAV ITGAV SMAD7 SMAD7 SMURF1 SMURF1 CDKN2B CDKN2B FBN1 FBN1 ENSNLEP00000046336 ENSNLEP00000046336 ITGB5 ITGB5 SKIL SKIL RPS27A RPS27A PMEPA1 PMEPA1 ENSNLEP00000044256 ENSNLEP00000044256 ENSNLEP00000044164 ENSNLEP00000044164 ENSNLEP00000043660 ENSNLEP00000043660 ENSNLEP00000043421 ENSNLEP00000043421 ENSNLEP00000043312 ENSNLEP00000043312 NEDD4L NEDD4L TFDP2 TFDP2 SMAD3 SMAD3 TGFBR1 TGFBR1 ENSNLEP00000041069 ENSNLEP00000041069 STRAP STRAP LOC100582696 LOC100582696 CCNC CCNC ENSNLEP00000039422 ENSNLEP00000039422 ENSNLEP00000038869 ENSNLEP00000038869 LTBP2 LTBP2 ENSNLEP00000038579 ENSNLEP00000038579 ENSNLEP00000037583 ENSNLEP00000037583 ENSNLEP00000036875 ENSNLEP00000036875 ENSNLEP00000036789 ENSNLEP00000036789 ENSNLEP00000036737 ENSNLEP00000036737 IRX4 IRX4 EP300 EP300 PRKCZ PRKCZ CCNK CCNK TFDP1 TFDP1 IRX5 IRX5 IRX6 IRX6 LOC100602359 LOC100602359 MAPK3 MAPK3 NCOR2 NCOR2 HDAC1 HDAC1 E2F5 E2F5 MEIS3 MEIS3 WWTR1 WWTR1 PPP1CC PPP1CC TGFBR2 TGFBR2 E2F4 E2F4 TRIM33 TRIM33 PARD6A PARD6A MEN1 MEN1 MYC MYC LTBP3 LTBP3 KXD1 KXD1 TGIF2 TGIF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF111Ring finger protein 111. (995 aa)
UBE2MUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (86 aa)
IRX2Iroquois homeobox 2. (471 aa)
CGNCingulin. (1090 aa)
XPO1Exportin 1. (1091 aa)
MTMR4Myotubularin related protein 4. (1163 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
STUB1Uncharacterized protein. (231 aa)
CBLCbl proto-oncogene. (905 aa)
PARD3BUncharacterized protein. (932 aa)
NEDD8NEDD8 ubiquitin like modifier. (81 aa)
ENSNLEP00000031295WD_REPEATS_REGION domain-containing protein. (301 aa)
TGIF1TGFB induced factor homeobox 1. (400 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (730 aa)
SNW1SNW domain containing 1. (571 aa)
PARD3Par-3 family cell polarity regulator. (1273 aa)
FKBP1APeptidylprolyl isomerase. (139 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
ENSNLEP00000027025PPM-type phosphatase domain-containing protein. (340 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2507 aa)
ENSNLEP00000025225CYCLIN domain-containing protein; Belongs to the cyclin family. (228 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
F11RF11 receptor. (299 aa)
LOC100581805Uncharacterized protein. (1144 aa)
RPS27A-2Ubiquitin-like domain-containing protein. (156 aa)
RHOARas homolog family member A. (193 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1421 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (726 aa)
SP1Sp1 transcription factor. (786 aa)
CDK9Cyclin dependent kinase 9. (372 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
MKXMohawk homeobox. (352 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (725 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1698 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1574 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (948 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
CCNQCYCLIN domain-containing protein; Belongs to the cyclin family. (248 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)
YBX1Y-box binding protein 1. (324 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (785 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
IRX3Iroquois homeobox 3. (476 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (677 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
ENSNLEP00000034619Ubiquitin-like domain-containing protein. (77 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (327 aa)
ENSNLEP00000034935Uncharacterized protein. (310 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1008 aa)
SMAD7Mothers against decapentaplegic homolog. (376 aa)
SMURF1E3 ubiquitin-protein ligase. (749 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
FBN1Fibrillin 1. (2873 aa)
ENSNLEP00000046336Transcription factor. (371 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (859 aa)
SKILSKI like proto-oncogene. (683 aa)
RPS27AUbiquitin-like domain-containing protein. (161 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (274 aa)
ENSNLEP00000044256CSP domain-containing protein. (264 aa)
ENSNLEP00000044164CYCLIN domain-containing protein; Belongs to the cyclin family. (248 aa)
ENSNLEP00000043660CSP domain-containing protein. (328 aa)
ENSNLEP00000043421Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (393 aa)
ENSNLEP00000043312Homeobox domain-containing protein. (242 aa)
NEDD4LUncharacterized protein. (1236 aa)
TFDP2Transcription factor. (403 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ENSNLEP00000041069Uncharacterized protein. (115 aa)
STRAPSerine/threonine kinase receptor associated protein. (364 aa)
LOC100582696Uncharacterized protein. (329 aa)
CCNCCyclin C; Belongs to the cyclin family. (282 aa)
ENSNLEP00000039422Ubiquitin-like domain-containing protein. (136 aa)
ENSNLEP00000038869Ubiquitin-like domain-containing protein. (156 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1738 aa)
ENSNLEP00000038579Ubiquitin-like domain-containing protein. (104 aa)
ENSNLEP00000037583Ubiquitin-like domain-containing protein. (79 aa)
ENSNLEP00000036875Peptidylprolyl isomerase. (147 aa)
ENSNLEP00000036789SKIP_SNW domain-containing protein. (443 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
IRX4Homeobox domain-containing protein. (452 aa)
EP300E1A binding protein p300. (2306 aa)
PRKCZProtein kinase C zeta. (507 aa)
CCNKCyclin K; Belongs to the cyclin family. (545 aa)
TFDP1Transcription factor. (395 aa)
IRX5Iroquois homeobox 5. (483 aa)
IRX6Iroquois homeobox 6. (447 aa)
LOC100602359Uncharacterized protein. (479 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
NCOR2Nuclear receptor corepressor 2. (2373 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
E2F5E2F transcription factor 5. (346 aa)
MEIS3Homeobox domain-containing protein. (324 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (334 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
E2F4E2F transcription factor 4. (397 aa)
TRIM33Tripartite motif containing 33. (1002 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
MEN1Menin 1. (614 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
LTBP3Uncharacterized protein. (1148 aa)
KXD1KxDL motif containing 1. (195 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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