STRINGSTRING
PLCG1 PLCG1 CASS4 CASS4 PDGFA PDGFA PDGFRA PDGFRA HRAS HRAS PDGFRB PDGFRB STAT5B STAT5B STAT3 STAT3 RAPGEF1 RAPGEF1 RASA1 RASA1 EFS EFS PDGFB PDGFB SOS1 SOS1 STAT6 STAT6 ERAS ERAS M3ZBW0_NOMLE M3ZBW0_NOMLE ENSNLEP00000024736 ENSNLEP00000024736 ENSNLEP00000027584 ENSNLEP00000027584 NCK2 NCK2 PIK3R1 PIK3R1 ENSNLEP00000032399 ENSNLEP00000032399 STAT1 STAT1 LOC100605369 LOC100605369 CSDE1 CSDE1 FNDC3A FNDC3A NEDD9 NEDD9 NRAS NRAS GRB2 GRB2 BCAR1 BCAR1 ENSNLEP00000043688 ENSNLEP00000043688 SRC SRC PTPN11 PTPN11 CRKL CRKL CRK CRK GRB7 GRB7 NCK1 NCK1 PIK3CB PIK3CB KRAS KRAS FNDC3B FNDC3B PIK3CA PIK3CA PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1046 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
STAT5BSignal transducer and activator of transcription. (650 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1110 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
ERASES cell expressed Ras. (233 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
NCK2Cytoplasmic protein. (380 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
LOC100605369Uncharacterized protein. (571 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (838 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
SRCTyrosine-protein kinase. (537 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CRKUncharacterized protein. (252 aa)
GRB7Growth factor receptor bound protein 7. (476 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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