STRINGSTRING
COL5A2 COL5A2 COL3A1 COL3A1 PLCG1 PLCG1 PIK3R2 PIK3R2 PIK3CA PIK3CA FNDC3B FNDC3B KRAS KRAS PIK3CB PIK3CB NCK1 NCK1 COL6A1 COL6A1 COL6A6 COL6A6 COL6A5 COL6A5 LOC100602359 LOC100602359 THBS2 THBS2 GRB7 GRB7 COL9A1 COL9A1 CRK CRK CRKL CRKL PTPN11 PTPN11 COL6A2 COL6A2 SRC SRC COL4A3 COL4A3 ENSNLEP00000044084 ENSNLEP00000044084 THBS1 THBS1 ENSNLEP00000043688 ENSNLEP00000043688 PTPN12 PTPN12 BCAR1 BCAR1 GRB2 GRB2 NRAS NRAS PDGFC PDGFC NEDD9 NEDD9 FNDC3A FNDC3A CSDE1 CSDE1 COL4A5 COL4A5 LOC100605369 LOC100605369 ENSNLEP00000034896 ENSNLEP00000034896 STAT1 STAT1 ENSNLEP00000032399 ENSNLEP00000032399 PIK3R1 PIK3R1 NCK2 NCK2 PLAT PLAT ENSNLEP00000027584 ENSNLEP00000027584 THBS3 THBS3 PDGFD PDGFD ENSNLEP00000024736 ENSNLEP00000024736 M3ZBW0_NOMLE M3ZBW0_NOMLE ERAS ERAS COL2A1 COL2A1 STAT6 STAT6 SOS1 SOS1 PDGFB PDGFB EFS EFS RASA1 RASA1 COL4A4 COL4A4 THBS4 THBS4 RAPGEF1 RAPGEF1 FURIN FURIN COL9A2 COL9A2 COL5A3 COL5A3 STAT3 STAT3 STAT5B STAT5B PLG PLG COL6A3 COL6A3 PDGFRB PDGFRB COL9A3 COL9A3 SPP1 SPP1 HRAS HRAS PDGFRA PDGFRA PDGFA PDGFA COL4A2 COL4A2 COL4A1 COL4A1 CASS4 CASS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COL5A2Collagen type V alpha 2 chain. (1499 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
PIK3R2Uncharacterized protein. (727 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NCK1Cytoplasmic protein. (377 aa)
COL6A1Uncharacterized protein. (989 aa)
COL6A6Collagen type VI alpha 6 chain. (2233 aa)
COL6A5Collagen type VI alpha 5 chain. (2590 aa)
LOC100602359Uncharacterized protein. (479 aa)
THBS2Thrombospondin 2. (1101 aa)
GRB7Growth factor receptor bound protein 7. (476 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
CRKUncharacterized protein. (252 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
COL6A2Collagen type VI alpha 2 chain. (961 aa)
SRCTyrosine-protein kinase. (537 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
ENSNLEP00000044084Fibrillar collagen NC1 domain-containing protein. (1527 aa)
THBS1Thrombospondin 1. (1173 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (755 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (838 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
CSDE1Cold shock domain containing E1. (844 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
LOC100605369Uncharacterized protein. (571 aa)
ENSNLEP00000034896Uncharacterized protein. (651 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
NCK2Cytoplasmic protein. (380 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
THBS3Thrombospondin 3. (938 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
ERASES cell expressed Ras. (233 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
COL4A4Collagen type IV alpha 4 chain. (1678 aa)
THBS4Thrombospondin 4. (925 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1110 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (785 aa)
COL9A2Collagen type IX alpha 2 chain. (661 aa)
COL5A3Collagen type V alpha 3 chain. (1693 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5BSignal transducer and activator of transcription. (650 aa)
PLGApple domain-containing protein. (97 aa)
COL6A3Collagen type VI alpha 3 chain. (3149 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
COL9A3Uncharacterized protein. (589 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1046 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
COL4A2Collagen type IV alpha 2 chain. (1647 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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