STRINGSTRING
CREB1 CREB1 MAPKAPK3 MAPKAPK3 PPP4R1 PPP4R1 ADCYAP1 ADCYAP1 RHOA RHOA YWHAB YWHAB PLCG1 PLCG1 AP2M1 AP2M1 SHC4 SHC4 FOSL1 FOSL1 PIK3R2 PIK3R2 PIK3CA PIK3CA DUSP3 DUSP3 TRIB1 TRIB1 AP2A1 AP2A1 KRAS KRAS PPP2R5D PPP2R5D CHD4 CHD4 PIK3CB PIK3CB SRF SRF RRAD RRAD CDK5 CDK5 RAP1A RAP1A NTRK2 NTRK2 ELK1 ELK1 MAP2K2 MAP2K2 RALA RALA BRAF BRAF G1QNP0_NOMLE G1QNP0_NOMLE FOSB FOSB MAPK3 MAPK3 RALB RALB CLTC CLTC MAPKAPK2 MAPKAPK2 CRK CRK SHC2 SHC2 MAPK12 MAPK12 CRKL CRKL VRK3 VRK3 AP2B1 AP2B1 CREM CREM DNM2 DNM2 ENSNLEP00000029200 ENSNLEP00000029200 NGF NGF ENSNLEP00000030293 ENSNLEP00000030293 ENSNLEP00000031226 ENSNLEP00000031226 ADCYAP1R1 ADCYAP1R1 TCF12 TCF12 PIK3R1 PIK3R1 PPP2R1B PPP2R1B ENSNLEP00000036737 ENSNLEP00000036737 ENSNLEP00000036861 ENSNLEP00000036861 ENSNLEP00000032399 ENSNLEP00000032399 ATF2 ATF2 MEF2C MEF2C JUNB JUNB IRS1 IRS1 SHC3 SHC3 EP300 EP300 CLTA CLTA MAP2K1 MAP2K1 ENSNLEP00000036455 ENSNLEP00000036455 FRS2 FRS2 PPP2R1A PPP2R1A MEF2D MEF2D KIDINS220 KIDINS220 NKPD1 NKPD1 CSDE1 CSDE1 DNM1 DNM1 RIT2 RIT2 ENSNLEP00000039370 ENSNLEP00000039370 FNBP4 FNBP4 NRAS NRAS GRB2 GRB2 PPP2CA PPP2CA ENSNLEP00000042687 ENSNLEP00000042687 ENSNLEP00000042936 ENSNLEP00000042936 ASCL2 ASCL2 DUSP6 DUSP6 EGR2 EGR2 IRS2 IRS2 ENSNLEP00000046563 ENSNLEP00000046563 NTRK1 NTRK1 FOS FOS SH3GL2 SH3GL2 SRC SRC DUSP7 DUSP7 NAB1 NAB1 MAPK11 MAPK11 ID3 ID3 ATF1 ATF1 TPH1 TPH1 NAB2 NAB2 PPP4R4 PPP4R4 DUSP4 DUSP4 SOS1 SOS1 EGR3 EGR3 ADORA2A ADORA2A DNM3 DNM3 DNAL4 DNAL4 SGK1 SGK1 TRIB2 TRIB2 ID2 ID2 MAP2K5 MAP2K5 RALGDS RALGDS LYL1 LYL1 RAPGEF1 RAPGEF1 RIT1 RIT1 PPP2CB PPP2CB RPS6KA2 RPS6KA2 SHC1 SHC1 STAT3 STAT3 F3 F3 SH3GL3 SH3GL3 RPS6KA3 RPS6KA3 ID1 ID1 RPS6KA1 RPS6KA1 MAPK1 MAPK1 MEF2A MEF2A AP2S1 AP2S1 MAPK14 MAPK14 CDK5R2 CDK5R2 ERAS ERAS ASCL1 ASCL1 RPS6KA5 RPS6KA5 MAPK13 MAPK13 EGR1 EGR1 REST REST AP2A2 AP2A2 MAPK7 MAPK7 RELCH RELCH HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (950 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
RHOARas homolog family member A. (193 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
SHC4SHC adaptor protein 4. (604 aa)
FOSL1BZIP domain-containing protein. (271 aa)
PIK3R2Uncharacterized protein. (727 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
TRIB1Tribbles pseudokinase 1. (321 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (906 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (607 aa)
CHD4Uncharacterized protein. (1987 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
SRFSerum response factor. (508 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ELK1ETS transcription factor ELK1. (390 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (383 aa)
RALARAS like proto-oncogene A. (206 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
G1QNP0_NOMLEProtein kinase domain-containing protein. (234 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
RALBRAS like proto-oncogene B. (212 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
CRKUncharacterized protein. (252 aa)
SHC2Uncharacterized protein. (516 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
VRK3VRK serine/threonine kinase 3. (474 aa)
AP2B1AP complex subunit beta. (951 aa)
CREMcAMP responsive element modulator. (344 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (770 aa)
ENSNLEP00000029200C2H2-type domain-containing protein. (398 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
ENSNLEP00000030293Uncharacterized protein. (912 aa)
ENSNLEP00000031226AP complex subunit beta. (907 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (500 aa)
TCF12Transcription factor 12. (706 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (327 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
SHC3SHC adaptor protein 3. (598 aa)
EP300E1A binding protein p300. (2306 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSNLEP00000036455Uncharacterized protein. (127 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
KIDINS220Kinase D interacting substrate 220. (1733 aa)
NKPD1NTPase KAP family P-loop domain containing 1. (608 aa)
CSDE1Cold shock domain containing E1. (844 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (827 aa)
RIT2Ras like without CAAX 2. (217 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
FNBP4Formin binding protein 4. (1022 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ENSNLEP00000042687Uncharacterized protein. (245 aa)
ENSNLEP00000042936Protein kinase domain-containing protein. (201 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
EGR2Early growth response 2. (476 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
SRCTyrosine-protein kinase. (537 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
NAB1NGFI-A binding protein 1. (487 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
ATF1Activating transcription factor 1. (270 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
NAB2NGFI-A binding protein 2. (525 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (855 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGR3Early growth response 3. (387 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
DNAL4Dynein light chain. (105 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (414 aa)
RALGDSUncharacterized protein. (916 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1110 aa)
RIT1Ras like without CAAX 1. (236 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (692 aa)
SHC1SHC adaptor protein 1. (542 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
ERASES cell expressed Ras. (233 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
RPS6KA5Ribosomal protein S6 kinase. (797 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
RESTRE1 silencing transcription factor. (1097 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (923 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1219 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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