STRINGSTRING
NRP2 NRP2 ABI1 ABI1 AKT2 AKT2 BCAR1 BCAR1 CTNND1 CTNND1 FYN FYN CDC42 CDC42 LOC100593010 LOC100593010 NRAS NRAS ENSNLEP00000040381 ENSNLEP00000040381 ITPR3 ITPR3 PRR5 PRR5 NEDD9 NEDD9 PAK1 PAK1 FNDC3A FNDC3A PRKACG PRKACG CSDE1 CSDE1 ACTB ACTB PAK3 PAK3 AAMP AAMP MLST8 MLST8 ENSNLEP00000036737 ENSNLEP00000036737 LOC100603674 LOC100603674 ITGAV ITGAV ROCK2 ROCK2 NCKAP1 NCKAP1 PTK2 PTK2 ELMO2 ELMO2 ITPR2 ITPR2 NCKAP1L NCKAP1L VEGFA VEGFA MTOR MTOR BAIAP2 BAIAP2 CTNNA1 CTNNA1 ENSNLEP00000033007 ENSNLEP00000033007 PGF PGF ENSNLEP00000032399 ENSNLEP00000032399 ITGB3 ITGB3 CAV1 CAV1 PIK3R1 PIK3R1 NCK2 NCK2 TENM2 TENM2 CYFIP1 CYFIP1 PRKACB PRKACB CYFIP2 CYFIP2 AKT1 AKT1 ENSNLEP00000027935 ENSNLEP00000027935 STX12 STX12 VAV1 VAV1 ENSNLEP00000026528 ENSNLEP00000026528 HSP90AA1 HSP90AA1 MAPK11 MAPK11 PRKACA PRKACA NRP1 NRP1 MAPK14 MAPK14 AKT3 AKT3 ACTG1 ACTG1 ACTL9 ACTL9 ACTL7A ACTL7A ACTL7B ACTL7B ERAS ERAS RNF222 RNF222 NCF2 NCF2 VEGFC VEGFC RICTOR RICTOR TGFB1I1 TGFB1I1 ROCK1 ROCK1 PRKCB PRKCB KDR KDR ACTRT2 ACTRT2 ENSNLEP00000045775 ENSNLEP00000045775 TENM4 TENM4 MAPKAP1 MAPKAP1 VAV2 VAV2 PXN PXN AXL AXL SRC SRC LOC100595279 LOC100595279 PTK2B PTK2B RAC1 RAC1 TENM1 TENM1 EFS EFS G1RX97_NOMLE G1RX97_NOMLE STX7 STX7 WASF3 WASF3 RASA1 RASA1 LPXN LPXN SH2D2A SH2D2A WASF1 WASF1 SHE SHE JUP JUP TENM3 TENM3 THEM4 THEM4 WASF2 WASF2 TRIB3 TRIB3 LOC100592336 LOC100592336 VEGFD VEGFD MAPK13 MAPK13 HRAS HRAS SZRD1 SZRD1 ACTL8 ACTL8 PRKCD PRKCD ABI2 ABI2 CASS4 CASS4 MAPKAPK3 MAPKAPK3 RHOA RHOA PLCG1 PLCG1 PIK3R2 PIK3R2 SHF SHF CTNNB1 CTNNB1 PIK3CA PIK3CA ARVCF ARVCF FNDC3B FNDC3B HSH2D HSH2D KRAS KRAS VEGFB VEGFB ELMO3 ELMO3 PIK3CB PIK3CB NCK1 NCK1 NOS3 NOS3 CDH5 CDH5 ITPR1 ITPR1 SHB SHB AHCYL1 AHCYL1 SHD SHD ELMO1 ELMO1 FLT4 FLT4 SPHK1 SPHK1 PAK2 PAK2 VAV3 VAV3 CYBB CYBB MAPKAPK2 MAPKAPK2 CRK CRK SHC2 SHC2 MAPK12 MAPK12 FLT1 FLT1 DOCK1 DOCK1 PRKCA PRKCA PRKCZ PRKCZ ENSNLEP00000042609 ENSNLEP00000042609
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
ABI1Abl interactor 1. (508 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
CTNND1Catenin delta 1. (968 aa)
FYNTyrosine-protein kinase. (537 aa)
CDC42Cell division cycle 42. (191 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSNLEP00000040381Uncharacterized protein. (760 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2755 aa)
PRR5Proline rich 5. (410 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (838 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PRKACGUncharacterized protein. (290 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ACTBUncharacterized protein. (363 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
AAMPAngio associated migratory cell protein. (434 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
LOC100603674Uncharacterized protein. (371 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1008 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
NCKAP1NCK associated protein 1. (1134 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
NCKAP1LNCK associated protein 1 like. (1109 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
CTNNA1Catenin alpha 1. (895 aa)
ENSNLEP00000033007Uncharacterized protein; Belongs to the actin family. (312 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
NCK2Cytoplasmic protein. (380 aa)
TENM2Teneurin transmembrane protein 2. (2774 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1228 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
VAV1Uncharacterized protein. (739 aa)
ENSNLEP00000026528Uncharacterized protein. (337 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (901 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ACTG1Actin gamma 1. (378 aa)
ACTL9Actin like 9; Belongs to the actin family. (416 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
ERASES cell expressed Ras. (233 aa)
RNF222Ring finger protein 222. (220 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1709 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (460 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (369 aa)
ENSNLEP00000045775Uncharacterized protein. (113 aa)
TENM4Teneurin transmembrane protein 4. (2768 aa)
MAPKAP1MAPK associated protein 1. (523 aa)
VAV2Vav guanine nucleotide exchange factor 2. (788 aa)
PXNUncharacterized protein. (1078 aa)
AXLReceptor protein-tyrosine kinase. (860 aa)
SRCTyrosine-protein kinase. (537 aa)
LOC100595279Uncharacterized protein. (212 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
RAC1Rac family small GTPase 1. (187 aa)
TENM1Teneurin transmembrane protein 1. (2731 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
G1RX97_NOMLEUncharacterized protein. (247 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
WASF3WASP family member 3. (502 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)
SH2D2ASH2 domain containing 2A. (399 aa)
WASF1WASP family member 1. (547 aa)
SHESrc homology 2 domain containing E. (495 aa)
JUPJunction plakoglobin. (730 aa)
TENM3Teneurin transmembrane protein 3. (2699 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
WASF2WH2 domain-containing protein. (401 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SZRD1SUZ RNA binding domain containing 1. (152 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ABI2Abl interactor 2. (462 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
RHOARas homolog family member A. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
PIK3R2Uncharacterized protein. (727 aa)
SHFSrc homology 2 domain containing F. (418 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
ARVCFARVCF delta catenin family member. (918 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
HSH2DHematopoietic SH2 domain containing. (352 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
ELMO3Engulfment and cell motility 3. (694 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
NCK1Cytoplasmic protein. (377 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (687 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
SHBSH2 domain-containing protein. (355 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (529 aa)
SHDSrc homology 2 domain containing transforming protein D. (297 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
VAV3Vav guanine nucleotide exchange factor 3. (799 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
CRKUncharacterized protein. (252 aa)
SHC2Uncharacterized protein. (516 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PRKCZProtein kinase C zeta. (507 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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