STRINGSTRING
ATF2 ATF2 MAPKAPK2 MAPKAPK2 MAPK3 MAPK3 FOSB FOSB G1QNP0_NOMLE G1QNP0_NOMLE ELK1 ELK1 CDK5 CDK5 RRAD RRAD SRF SRF CHD4 CHD4 PPP2R5D PPP2R5D TRIB1 TRIB1 DUSP3 DUSP3 FOSL1 FOSL1 PPP4R1 PPP4R1 CREB1 CREB1 RELCH RELCH MAPK7 MAPK7 REST REST EGR1 EGR1 RPS6KA1 RPS6KA1 ID1 ID1 RPS6KA3 RPS6KA3 SH3GL3 SH3GL3 F3 F3 RPS6KA2 RPS6KA2 PPP2CB PPP2CB LYL1 LYL1 ID2 ID2 TRIB2 TRIB2 SGK1 SGK1 EGR3 EGR3 DUSP4 DUSP4 PPP4R4 PPP4R4 NAB2 NAB2 TPH1 TPH1 ATF1 ATF1 CDK5R2 CDK5R2 MAPK14 MAPK14 MEF2A MEF2A MAPK11 MAPK11 NAB1 NAB1 DUSP7 DUSP7 MAPK1 MAPK1 ID3 ID3 ASCL1 ASCL1 RPS6KA5 RPS6KA5 VRK3 VRK3 CREM CREM DNM2 DNM2 ENSNLEP00000029200 ENSNLEP00000029200 TCF12 TCF12 PPP2R1B PPP2R1B MEF2C MEF2C JUNB JUNB EP300 EP300 PPP2R1A PPP2R1A ENSNLEP00000036861 ENSNLEP00000036861 MEF2D MEF2D FNBP4 FNBP4 PPP2CA PPP2CA ENSNLEP00000042687 ENSNLEP00000042687 ASCL2 ASCL2 DUSP6 DUSP6 EGR2 EGR2 FOS FOS
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
G1QNP0_NOMLEProtein kinase domain-containing protein. (234 aa)
ELK1ETS transcription factor ELK1. (390 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
SRFSerum response factor. (508 aa)
CHD4Uncharacterized protein. (1987 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (607 aa)
TRIB1Tribbles pseudokinase 1. (321 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
FOSL1BZIP domain-containing protein. (271 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (950 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1219 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
RESTRE1 silencing transcription factor. (1097 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (692 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
EGR3Early growth response 3. (387 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (855 aa)
NAB2NGFI-A binding protein 2. (525 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
ATF1Activating transcription factor 1. (270 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
NAB1NGFI-A binding protein 1. (487 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
RPS6KA5Ribosomal protein S6 kinase. (797 aa)
VRK3VRK serine/threonine kinase 3. (474 aa)
CREMcAMP responsive element modulator. (344 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (770 aa)
ENSNLEP00000029200C2H2-type domain-containing protein. (398 aa)
TCF12Transcription factor 12. (706 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (327 aa)
EP300E1A binding protein p300. (2306 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
FNBP4Formin binding protein 4. (1022 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ENSNLEP00000042687Uncharacterized protein. (245 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
EGR2Early growth response 2. (476 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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