STRINGSTRING
MYCN MYCN HIF1A HIF1A SRC SRC ENSNLEP00000046563 ENSNLEP00000046563 SIN3A SIN3A ENSNLEP00000043421 ENSNLEP00000043421 ENSNLEP00000039370 ENSNLEP00000039370 HDAC2 HDAC2 FRS2 FRS2 EP300 EP300 IRS1 IRS1 ENSNLEP00000032399 ENSNLEP00000032399 PIK3R1 PIK3R1 PTN PTN ALK ALK ROS1 ROS1 PRDM1 PRDM1 PTPRZ1 PTPRZ1 SHC1 SHC1 STAT3 STAT3 HDAC3 HDAC3 CD274 CD274 PLCG1 PLCG1 PIK3R2 PIK3R2 JAK3 JAK3 PIK3CA PIK3CA MYC MYC PTPN6 PTPN6 PIK3CB PIK3CB LTK LTK HDAC1 HDAC1 IL2RG IL2RG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYCNBHLH domain-containing protein. (442 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SRCTyrosine-protein kinase. (537 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
SIN3ASIN3 transcription regulator family member A. (1250 aa)
ENSNLEP00000043421Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (393 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
EP300E1A binding protein p300. (2306 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
PTNPleiotrophin. (172 aa)
ALKUncharacterized protein. (1134 aa)
ROS1Tyrosine-protein kinase receptor. (2347 aa)
PRDM1PR/SET domain 1. (825 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2315 aa)
SHC1SHC adaptor protein 1. (542 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CD274CD274 molecule. (290 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
PIK3R2Uncharacterized protein. (727 aa)
JAK3Tyrosine-protein kinase. (1025 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (627 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
LTKLeukocyte receptor tyrosine kinase. (864 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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