STRINGSTRING
THEM4 THEM4 FGF3 FGF3 SHC1 SHC1 FGFR1 FGFR1 FGFR4 FGFR4 FGF9 FGF9 FGF8 FGF8 SOS1 SOS1 GAB2 GAB2 FGFR2 FGFR2 KLB KLB PDE3B PDE3B IRS4 IRS4 ERAS ERAS ENSNLEP00000024736 ENSNLEP00000024736 FGFR3 FGFR3 FGF20 FGF20 ENSNLEP00000027584 ENSNLEP00000027584 FGF10 FGF10 PIK3C3 PIK3C3 IGF2 IGF2 PIK3R1 PIK3R1 ENSNLEP00000032399 ENSNLEP00000032399 LOC100605369 LOC100605369 IRS1 IRS1 PIK3R4 PIK3R4 FRS2 FRS2 FGF2 FGF2 ENSNLEP00000039370 ENSNLEP00000039370 FGF17 FGF17 NRAS NRAS LOC100593010 LOC100593010 GRB2 GRB2 ENSNLEP00000041179 ENSNLEP00000041179 AKT2 AKT2 ENSNLEP00000043688 ENSNLEP00000043688 IGF1R IGF1R IGF1 IGF1 ENSNLEP00000045775 ENSNLEP00000045775 IRS2 IRS2 ENSNLEP00000046563 ENSNLEP00000046563 FGF5 FGF5 HRAS HRAS GAB4 GAB4 G1R620_NOMLE G1R620_NOMLE FGF7 FGF7 PIK3R2 PIK3R2 PIK3CA PIK3CA GAB1 GAB1 KRAS KRAS FLT3LG FLT3LG LOC100592336 LOC100592336 PIK3CB PIK3CB FGF6 FGF6 FGF23 FGF23 KL KL FGF16 FGF16 FGF22 FGF22 SPEM1 SPEM1 TRIB3 TRIB3 FGF1 FGF1 FGF19 FGF19 FLT3 FLT3 G1QHL5_NOMLE G1QHL5_NOMLE PTPN11 PTPN11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THEM4Thioesterase superfamily member 4. (240 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
SHC1SHC adaptor protein 1. (542 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
GAB2GRB2 associated binding protein 2. (651 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
KLBKlotho beta. (1044 aa)
PDE3BPhosphodiesterase. (791 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
ERASES cell expressed Ras. (233 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
IGF2IlGF domain-containing protein. (180 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
LOC100605369Uncharacterized protein. (571 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSNLEP00000041179Spem1 domain-containing protein. (269 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
IGF1RTyrosine-protein kinase receptor. (1199 aa)
IGF1IlGF domain-containing protein. (196 aa)
ENSNLEP00000045775Uncharacterized protein. (113 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GAB4GRB2 associated binding protein family member 4. (575 aa)
G1R620_NOMLETIR domain-containing protein. (1031 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PIK3R2Uncharacterized protein. (727 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FLT3LGUncharacterized protein. (223 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
KLKlotho. (855 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
SPEM1Spermatid maturation 1. (309 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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