90 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSNLEP00000027935	Uncharacterized protein. (181 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (801 aa)
	ENSNLEP00000032002	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (116 aa)
	RND1	Rho family GTPase 1. (214 aa)
	ENSNLEP00000033778	Uncharacterized protein. (143 aa)
	MYL12B	Myosin light chain 12B. (172 aa)
	TLN1	Talin 1. (2542 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1029 aa)
	ENSNLEP00000034648	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (210 aa)
	MYL9	Myosin light chain 9. (172 aa)
	ENSNLEP00000035379	HATPase_c domain-containing protein. (297 aa)
	ENSNLEP00000035534	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (189 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
	LIMK1	Uncharacterized protein. (614 aa)
	ENSNLEP00000036326	Uncharacterized protein. (321 aa)
	ENSNLEP00000036737	Uncharacterized protein. (160 aa)
	ENSNLEP00000036861	Uncharacterized protein. (119 aa)
	ENSNLEP00000037385	Uncharacterized protein. (437 aa)
	PAK3	P21 (RAC1) activated kinase 3. (580 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (770 aa)
	PAK1	Non-specific serine/threonine protein kinase. (545 aa)
	TYROBP	Uncharacterized protein. (144 aa)
	PLXNA3	Plexin A3. (1828 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	RHOB	Ras homolog family member B. (196 aa)
	ENSNLEP00000041102	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (151 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	ENSNLEP00000042609	Uncharacterized protein. (168 aa)
	ENSNLEP00000043017	HATPase_c domain-containing protein. (648 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
	LIMK2	LIM domain kinase 2. (638 aa)
	MYL6	Uncharacterized protein. (236 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1047 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1892 aa)
	CD72	CD72 molecule. (365 aa)
	PLXNB3	Plexin B3. (1842 aa)
	PIP5K1C	PIPK domain-containing protein. (759 aa)
	DPYSL4	Dihydropyrimidinase like 4. (573 aa)
	RHOC	Ras homolog family member C. (209 aa)
	ENSNLEP00000048240	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (164 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1247 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	PLXNA1	Plexin A1. (1880 aa)
	PLXNA2	Plexin A2. (1909 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	DPYSL5	Dihydropyrimidinase like 5. (564 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1499 aa)
	CFL2	Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
	TREM2	Ig-like domain-containing protein. (222 aa)
	RRAS	RAS related. (217 aa)
	PLXND1	Plexin D1. (1603 aa)
	MYH14	Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1999 aa)
	PLXNC1	Plexin C1. (1305 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1073 aa)
	PLXNB1	Plexin B1. (2079 aa)
	RHOA	Ras homolog family member A. (193 aa)
	SEMA3G	Semaphorin 3G; Belongs to the semaphorin family. (782 aa)
	DPYSL3	Dihydropyrimidinase like 3. (684 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (921 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
	SEMA5A	Semaphorin 5A. (1074 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (836 aa)
	TLN2	Uncharacterized protein. (2289 aa)
	FES	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (828 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (758 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1557 aa)
	LOC100588496	FERM domain-containing protein. (263 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (901 aa)
	PKHD1	PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4073 aa)
	ENSNLEP00000024959	Uncharacterized protein. (131 aa)
	DSTN	Destrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (165 aa)
	CFL1	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (197 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (853 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (775 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
	PKHD1L1	PKHD1 like 1. (4280 aa)
	PLXNB2	Plexin B2. (1647 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (665 aa)
	PLXNA4	Plexin A4. (1864 aa)
	SEMA6B	Semaphorin 6B; Belongs to the semaphorin family. (857 aa)
	SEMA7A	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (664 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (771 aa)
	RAC1	Rac family small GTPase 1. (187 aa)
	CRMP1	Collapsin response mediator protein 1. (682 aa)
	DPYSL2	Dihydropyrimidinase like 2. (572 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1304 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	ARHGEF11	ENSNLEP00000003566	ENSNLEP00000015665	Rho GTPase activating protein 35.	Rho guanine nucleotide exchange factor 11.	0.422
ARHGAP35	CFL1	ENSNLEP00000003566	ENSNLEP00000025687	Rho GTPase activating protein 35.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.457
ARHGAP35	CFL2	ENSNLEP00000003566	ENSNLEP00000004152	Rho GTPase activating protein 35.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.534
ARHGAP35	ENSNLEP00000027935	ENSNLEP00000003566	ENSNLEP00000027935	Rho GTPase activating protein 35.	Uncharacterized protein.	0.452
ARHGAP35	ENSNLEP00000036737	ENSNLEP00000003566	ENSNLEP00000036737	Rho GTPase activating protein 35.	Uncharacterized protein.	0.826
ARHGAP35	ENSNLEP00000041102	ENSNLEP00000003566	ENSNLEP00000041102	Rho GTPase activating protein 35.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.457
ARHGAP35	ENSNLEP00000042609	ENSNLEP00000003566	ENSNLEP00000042609	Rho GTPase activating protein 35.	Uncharacterized protein.	0.452
ARHGAP35	ERBB2	ENSNLEP00000003566	ENSNLEP00000048945	Rho GTPase activating protein 35.	Receptor protein-tyrosine kinase.	0.428
ARHGAP35	FYN	ENSNLEP00000003566	ENSNLEP00000041056	Rho GTPase activating protein 35.	Tyrosine-protein kinase.	0.629
ARHGAP35	MET	ENSNLEP00000003566	ENSNLEP00000024614	Rho GTPase activating protein 35.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.624
ARHGAP35	PLXNB1	ENSNLEP00000003566	ENSNLEP00000007849	Rho GTPase activating protein 35.	Plexin B1.	0.499
ARHGAP35	PLXNB2	ENSNLEP00000003566	ENSNLEP00000000731	Rho GTPase activating protein 35.	Plexin B2.	0.424
ARHGAP35	PLXNB3	ENSNLEP00000003566	ENSNLEP00000045549	Rho GTPase activating protein 35.	Plexin B3.	0.416
ARHGAP35	RAC1	ENSNLEP00000003566	ENSNLEP00000019034	Rho GTPase activating protein 35.	Rac family small GTPase 1.	0.452
ARHGAP35	RHOA	ENSNLEP00000003566	ENSNLEP00000008325	Rho GTPase activating protein 35.	Ras homolog family member A.	0.996
ARHGAP35	RHOB	ENSNLEP00000003566	ENSNLEP00000041096	Rho GTPase activating protein 35.	Ras homolog family member B.	0.831
ARHGAP35	RHOC	ENSNLEP00000003566	ENSNLEP00000047321	Rho GTPase activating protein 35.	Ras homolog family member C.	0.806
ARHGAP35	RND1	ENSNLEP00000003566	ENSNLEP00000033646	Rho GTPase activating protein 35.	Rho family GTPase 1.	0.887
ARHGAP35	ROCK1	ENSNLEP00000003566	ENSNLEP00000043861	Rho GTPase activating protein 35.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.558
ARHGAP35	SEMA4D	ENSNLEP00000003566	ENSNLEP00000000506	Rho GTPase activating protein 35.	Semaphorin 4D; Belongs to the semaphorin family.	0.611

page 1 of 84

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About