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GNB1 GNB1 PRKCA PRKCA PDE6B PDE6B TCF7L1 TCF7L1 AGO2 AGO2 GNAO1 GNAO1 NLK NLK GNG8 GNG8 PLCB2 PLCB2 GNGT2 GNGT2 GNAT2 GNAT2 ITPR1 ITPR1 FZD6 FZD6 PDE6H PDE6H GNG3 GNG3 MOV10 MOV10 PLCB3 PLCB3 KRAS KRAS NFAT5 NFAT5 GNB4 GNB4 CTNNB1 CTNNB1 WNT5A WNT5A PRKG2 PRKG2 GNG5 GNG5 PDE6A PDE6A AGO4 AGO4 AGO3 AGO3 AGO1 AGO1 GNB2 GNB2 PRKG1 PRKG1 PDE6C PDE6C MAP3K7 MAP3K7 PLCB1 PLCB1 PDE6G PDE6G GNGT1 GNGT1 GNG11 GNG11 TCF7L2 TCF7L2 FZD3 FZD3 WNT11 WNT11 ERAS ERAS MAP3K20 MAP3K20 GNG13 GNG13 GNG4 GNG4 PPP3R1 PPP3R1 PPP3CB PPP3CB LOC100586578 LOC100586578 ENSNLEP00000028868 ENSNLEP00000028868 GNB3 GNB3 GNG2 GNG2 GNB5 GNB5 PPP3CA PPP3CA ITPR2 ITPR2 TNRC6B TNRC6B LEF1 LEF1 FZD4 FZD4 GNG12 GNG12 GNG7 GNG7 NFATC1 NFATC1 CAMK2A CAMK2A WDR92 WDR92 TCF7 TCF7 FZD5 FZD5 FZD2 FZD2 ITPR3 ITPR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNB1G protein subunit beta 1. (340 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PDE6BPhosphodiesterase 6B. (788 aa)
TCF7L1Transcription factor 7 like 1. (517 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (847 aa)
GNAO1G protein subunit alpha o1. (353 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1083 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
GNAT2G protein subunit alpha transducin 2. (354 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
PDE6HPhosphodiesterase 6H. (83 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MOV10Mov10 RISC complex RNA helicase. (976 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NFAT5Nuclear factor of activated T cells 5. (1547 aa)
GNB4G protein subunit beta 4. (340 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PDE6APhosphodiesterase. (860 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (854 aa)
AGO3Argonaute RISC catalytic component 3; Belongs to the argonaute family. (845 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
GNB2G protein subunit beta 2. (325 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PDE6CPhosphodiesterase. (858 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PDE6GUncharacterized protein. (126 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ERASES cell expressed Ras. (233 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (116 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
LOC100586578Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSNLEP00000028868G protein gamma domain-containing protein. (64 aa)
GNB3G protein subunit beta 3. (335 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
GNB5G protein subunit beta 5. (357 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1727 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
WDR92WD repeat domain 92. (357 aa)
TCF7HMG box domain-containing protein. (486 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2755 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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