STRINGSTRING
FZD6 FZD6 ENSNLEP00000049245 ENSNLEP00000049245 ENSNLEP00000048393 ENSNLEP00000048393 SMURF1 SMURF1 FZD5 FZD5 PSMD13 PSMD13 PFN1-2 PFN1-2 PSMB7 PSMB7 ENSNLEP00000046239 ENSNLEP00000046239 PSMD6 PSMD6 PSME4 PSME4 RPS27A RPS27A FZD2 FZD2 PRKCB PRKCB RAC3 RAC3 PSMB2 PSMB2 PSMD2 PSMD2 DVL2 DVL2 ENSNLEP00000042742 ENSNLEP00000042742 ENSNLEP00000042609 ENSNLEP00000042609 DVL1 DVL1 RAC2 RAC2 PSMD1 PSMD1 ENSNLEP00000041226 ENSNLEP00000041226 PSMB5 PSMB5 ENSNLEP00000040208 ENSNLEP00000040208 PSME3 PSME3 ENSNLEP00000039192 ENSNLEP00000039192 ENSNLEP00000039157 ENSNLEP00000039157 ENSNLEP00000038869 ENSNLEP00000038869 ENSNLEP00000038579 ENSNLEP00000038579 ENSNLEP00000038401 ENSNLEP00000038401 ENSNLEP00000037880 ENSNLEP00000037880 ENSNLEP00000037583 ENSNLEP00000037583 PSMB6 PSMB6 ENSNLEP00000036737 ENSNLEP00000036737 PSMF1 PSMF1 PRICKLE2 PRICKLE2 PSME2 PSME2 CLTA CLTA FZD4 FZD4 ENSNLEP00000034619 ENSNLEP00000034619 PSMB1 PSMB1 PSMD7 PSMD7 ENSNLEP00000032709 ENSNLEP00000032709 PSME1 PSME1 PSMD14 PSMD14 ENSNLEP00000031906 ENSNLEP00000031906 ENSNLEP00000031226 ENSNLEP00000031226 FZD7 FZD7 PSMD10 PSMD10 ENSNLEP00000030555 ENSNLEP00000030555 ENSNLEP00000030293 ENSNLEP00000030293 ENSNLEP00000029825 ENSNLEP00000029825 ENSNLEP00000029711 ENSNLEP00000029711 ENSNLEP00000029611 ENSNLEP00000029611 PSMA4 PSMA4 AP2B1 AP2B1 PSMA6 PSMA6 PSMA5 PSMA5 PSMD12 PSMD12 ENSNLEP00000027935 ENSNLEP00000027935 DAAM2 DAAM2 LOC100591996 LOC100591996 ENSNLEP00000026115 ENSNLEP00000026115 AP2S1 AP2S1 PSMA1 PSMA1 DVL3 DVL3 RPS27A-2 RPS27A-2 PRICKLE1 PRICKLE1 WNT1 WNT1 ARRB2 ARRB2 PSMD5 PSMD5 PSMC1 PSMC1 PSMD8 PSMD8 WNT11 WNT11 FZD3 FZD3 PSMA7 PSMA7 RAC1 RAC1 ROR1 ROR1 SMURF2 SMURF2 PSMC3 PSMC3 PSMC4 PSMC4 VANGL2 VANGL2 DAAM1 DAAM1 PSMA3 PSMA3 PSMC6 PSMC6 CLTB CLTB PSMB4 PSMB4 PSMD4 PSMD4 PSMC2 PSMC2 AP2A2 AP2A2 WNT4 WNT4 PRICKLE3 PRICKLE3 WNT5A WNT5A RHOA RHOA PSMB9 PSMB9 PSMB8 PSMB8 PSMA8 PSMA8 PRKCG PRKCG AP2M1 AP2M1 PSMD11 PSMD11 FHDC1 FHDC1 AP2A1 AP2A1 PSMB10 PSMB10 PRICKLE4 PRICKLE4 PARD6A PARD6A PSMC5 PSMC5 RYK RYK PSMA2 PSMA2 WNT5B WNT5B SCRIB SCRIB PSMD3 PSMD3 PSMD9 PSMD9 CLTC CLTC PSMB3 PSMB3 ROR2 ROR2 PRKCA PRKCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
ENSNLEP00000049245AAA domain-containing protein. (394 aa)
ENSNLEP00000048393VWFA domain-containing protein. (326 aa)
SMURF1E3 ubiquitin-protein ligase. (749 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (397 aa)
PFN1-2Profilin; Belongs to the profilin family. (128 aa)
PSMB7Proteasome subunit beta. (277 aa)
ENSNLEP00000046239Prot_ATP_ID_OB domain-containing protein. (183 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
PSME4Proteasome activator subunit 4. (1821 aa)
RPS27AUbiquitin-like domain-containing protein. (161 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
RAC3Rac family small GTPase 3. (205 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
DVL2Dishevelled segment polarity protein 2. (713 aa)
ENSNLEP00000042742Proteasome subunit alpha type. (233 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
DVL1Dishevelled segment polarity protein 1. (667 aa)
RAC2Rac family small GTPase 2. (192 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (957 aa)
ENSNLEP00000041226ATPase_AAA_core domain-containing protein. (461 aa)
PSMB5Proteasome subunit beta. (263 aa)
ENSNLEP00000040208AAA domain-containing protein. (406 aa)
PSME3Proteasome activator subunit 3. (239 aa)
ENSNLEP00000039192Uncharacterized protein. (179 aa)
ENSNLEP00000039157CSN8_PSD8_EIF3K domain-containing protein. (225 aa)
ENSNLEP00000038869Ubiquitin-like domain-containing protein. (156 aa)
ENSNLEP00000038579Ubiquitin-like domain-containing protein. (104 aa)
ENSNLEP00000038401ANK_REP_REGION domain-containing protein. (141 aa)
ENSNLEP00000037880Uncharacterized protein. (341 aa)
ENSNLEP00000037583Ubiquitin-like domain-containing protein. (79 aa)
PSMB6Proteasome subunit beta. (244 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PRICKLE2Prickle planar cell polarity protein 2. (886 aa)
PSME2Proteasome activator subunit 2. (256 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
ENSNLEP00000034619Ubiquitin-like domain-containing protein. (77 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
ENSNLEP00000032709Profilin; Belongs to the profilin family. (120 aa)
PSME1Proteasome activator subunit 1. (250 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (315 aa)
ENSNLEP00000031906Uncharacterized protein. (406 aa)
ENSNLEP00000031226AP complex subunit beta. (907 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSNLEP00000030555Protein kinase domain-containing protein. (200 aa)
ENSNLEP00000030293Uncharacterized protein. (912 aa)
ENSNLEP00000029825Uncharacterized protein. (351 aa)
ENSNLEP00000029711Uncharacterized protein. (230 aa)
ENSNLEP00000029611Proteasome subunit beta. (202 aa)
PSMA4Proteasome subunit alpha type. (241 aa)
AP2B1AP complex subunit beta. (951 aa)
PSMA6Proteasome subunit alpha type. (206 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (488 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1012 aa)
LOC100591996Proteasome endopeptidase complex. (164 aa)
ENSNLEP00000026115AAA domain-containing protein. (339 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
PSMA1Proteasome subunit alpha type. (268 aa)
DVL3Dishevelled segment polarity protein 3. (673 aa)
RPS27A-2Ubiquitin-like domain-containing protein. (156 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
ARRB2Arrestin beta 2. (430 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (509 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PSMA7Proteasome subunit alpha type. (265 aa)
RAC1Rac family small GTPase 1. (187 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
VANGL2Uncharacterized protein. (435 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1036 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (186 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (923 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
PRICKLE3Uncharacterized protein. (501 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
RHOARas homolog family member A. (193 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (459 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
FHDC1FH2 domain containing 1. (1122 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (906 aa)
PSMB10Proteasome subunit beta. (272 aa)
PRICKLE4Uncharacterized protein. (385 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
RYKReceptor like tyrosine kinase. (525 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SCRIBScribble planar cell polarity protein. (1449 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (528 aa)
PSMD9PDZ domain-containing protein. (222 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
PSMB3Proteasome subunit beta. (205 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (915 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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