STRINGSTRING
EFS EFS RAC1 RAC1 PTK2B PTK2B TGFB1I1 TGFB1I1 RICTOR RICTOR NCF2 NCF2 VAV3 VAV3 RNF222 RNF222 ERAS ERAS ACTL7B ACTL7B MAPKAPK2 MAPKAPK2 CRK CRK ENSNLEP00000045775 ENSNLEP00000045775 MAPKAP1 MAPKAP1 VAV2 VAV2 PXN PXN AXL AXL SRC SRC LOC100595279 LOC100595279 SHC2 SHC2 MAPK12 MAPK12 DOCK1 DOCK1 ACTL7A ACTL7A ACTL9 ACTL9 ACTG1 ACTG1 AKT3 AKT3 MAPK14 MAPK14 PRKACA PRKACA MAPK11 MAPK11 HSP90AA1 HSP90AA1 ENSNLEP00000026528 ENSNLEP00000026528 VAV1 VAV1 STX12 STX12 ENSNLEP00000027935 ENSNLEP00000027935 AKT1 AKT1 CYFIP2 CYFIP2 PRKACB PRKACB CYFIP1 CYFIP1 NCK2 NCK2 PIK3R1 PIK3R1 ACTRT2 ACTRT2 KDR KDR PRKCB PRKCB ROCK1 ROCK1 ENSNLEP00000042609 ENSNLEP00000042609 PRKCA PRKCA PRKCZ PRKCZ PRR5 PRR5 NEDD9 NEDD9 PAK1 PAK1 FNDC3A FNDC3A PRKACG PRKACG CSDE1 CSDE1 ACTB ACTB PAK3 PAK3 ABI1 ABI1 AKT2 AKT2 BCAR1 BCAR1 CTNND1 CTNND1 MLST8 MLST8 FYN FYN CDC42 CDC42 LOC100593010 LOC100593010 CAV1 CAV1 ITGB3 ITGB3 ENSNLEP00000032399 ENSNLEP00000032399 ENSNLEP00000033007 ENSNLEP00000033007 CTNNA1 CTNNA1 BAIAP2 BAIAP2 MTOR MTOR VEGFA VEGFA NCKAP1L NCKAP1L ITPR2 ITPR2 ELMO2 ELMO2 PTK2 PTK2 NCKAP1 NCKAP1 ROCK2 ROCK2 ITGAV ITGAV LOC100603674 LOC100603674 ENSNLEP00000036737 ENSNLEP00000036737 NRAS NRAS ENSNLEP00000040381 ENSNLEP00000040381 ITPR3 ITPR3 PAK2 PAK2 SPHK1 SPHK1 ELMO1 ELMO1 SHD SHD AHCYL1 AHCYL1 SHB SHB ITPR1 ITPR1 CDH5 CDH5 NOS3 NOS3 NCK1 NCK1 PIK3CB PIK3CB ELMO3 ELMO3 KRAS KRAS HSH2D HSH2D FNDC3B FNDC3B ARVCF ARVCF PIK3CA PIK3CA CTNNB1 CTNNB1 SHF SHF PIK3R2 PIK3R2 PLCG1 PLCG1 RHOA RHOA MAPKAPK3 MAPKAPK3 CASS4 CASS4 CYBB CYBB ABI2 ABI2 PRKCD PRKCD ACTL8 ACTL8 HRAS HRAS MAPK13 MAPK13 LOC100592336 LOC100592336 TRIB3 TRIB3 WASF2 WASF2 THEM4 THEM4 JUP JUP SHE SHE WASF1 WASF1 SH2D2A SH2D2A LPXN LPXN RASA1 RASA1 WASF3 WASF3 STX7 STX7 G1RX97_NOMLE G1RX97_NOMLE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFSEmbryonal Fyn-associated substrate. (561 aa)
RAC1Rac family small GTPase 1. (187 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (871 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (460 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1709 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
VAV3Vav guanine nucleotide exchange factor 3. (799 aa)
RNF222Ring finger protein 222. (220 aa)
ERASES cell expressed Ras. (233 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
CRKUncharacterized protein. (252 aa)
ENSNLEP00000045775Uncharacterized protein. (113 aa)
MAPKAP1MAPK associated protein 1. (523 aa)
VAV2Vav guanine nucleotide exchange factor 2. (788 aa)
PXNUncharacterized protein. (1078 aa)
AXLReceptor protein-tyrosine kinase. (860 aa)
SRCTyrosine-protein kinase. (537 aa)
LOC100595279Uncharacterized protein. (212 aa)
SHC2Uncharacterized protein. (516 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
ACTL9Actin like 9; Belongs to the actin family. (416 aa)
ACTG1Actin gamma 1. (378 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
ENSNLEP00000026528Uncharacterized protein. (337 aa)
VAV1Uncharacterized protein. (739 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1228 aa)
NCK2Cytoplasmic protein. (380 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (369 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PRKCZProtein kinase C zeta. (507 aa)
PRR5Proline rich 5. (410 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (838 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PRKACGUncharacterized protein. (290 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ACTBUncharacterized protein. (363 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ABI1Abl interactor 1. (508 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (827 aa)
CTNND1Catenin delta 1. (968 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
FYNTyrosine-protein kinase. (537 aa)
CDC42Cell division cycle 42. (191 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
ENSNLEP00000033007Uncharacterized protein; Belongs to the actin family. (312 aa)
CTNNA1Catenin alpha 1. (895 aa)
BAIAP2BAI1 associated protein 2. (561 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
NCKAP1LNCK associated protein 1 like. (1109 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
NCKAP1NCK associated protein 1. (1134 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1008 aa)
LOC100603674Uncharacterized protein. (371 aa)
ENSNLEP00000036737Uncharacterized protein. (160 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSNLEP00000040381Uncharacterized protein. (760 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2755 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
SHDSrc homology 2 domain containing transforming protein D. (297 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (529 aa)
SHBSH2 domain-containing protein. (355 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (687 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ELMO3Engulfment and cell motility 3. (694 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HSH2DHematopoietic SH2 domain containing. (352 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
ARVCFARVCF delta catenin family member. (918 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
CTNNB1Catenin beta 1. (781 aa)
SHFSrc homology 2 domain containing F. (418 aa)
PIK3R2Uncharacterized protein. (727 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
RHOARas homolog family member A. (193 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
ABI2Abl interactor 2. (462 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
WASF2WH2 domain-containing protein. (401 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
JUPJunction plakoglobin. (730 aa)
SHESrc homology 2 domain containing E. (495 aa)
WASF1WASP family member 1. (547 aa)
SH2D2ASH2 domain containing 2A. (399 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (387 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
WASF3WASP family member 3. (502 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
G1RX97_NOMLEUncharacterized protein. (247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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