STRINGSTRING
ERAS ERAS VEGFA VEGFA SRC SRC LOC100592336 LOC100592336 RASA1 RASA1 KDR KDR PRKCB PRKCB LOC100593010 LOC100593010 SPHK1 SPHK1 PRKCA PRKCA PRKCZ PRKCZ ITPR2 ITPR2 CSDE1 CSDE1 FNDC3A FNDC3A ITPR3 ITPR3 NRAS NRAS AHCYL1 AHCYL1 ITPR1 ITPR1 KRAS KRAS FNDC3B FNDC3B PLCG1 PLCG1 PRKCD PRKCD HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERASES cell expressed Ras. (233 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (393 aa)
SRCTyrosine-protein kinase. (537 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PRKCZProtein kinase C zeta. (507 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2755 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (529 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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