node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTK | IRAK4 | ENSNLEP00000009167 | ENSNLEP00000021784 | Tyrosine-protein kinase. | Interleukin 1 receptor associated kinase 4. | 0.744 |
BTK | LY96 | ENSNLEP00000009167 | ENSNLEP00000030565 | Tyrosine-protein kinase. | Lymphocyte antigen 96. | 0.418 |
BTK | MYD88 | ENSNLEP00000009167 | ENSNLEP00000006463 | Tyrosine-protein kinase. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.818 |
BTK | NFKB1 | ENSNLEP00000009167 | ENSNLEP00000016247 | Tyrosine-protein kinase. | Nuclear factor kappa B subunit 1. | 0.607 |
BTK | NFKBIA | ENSNLEP00000009167 | ENSNLEP00000004498 | Tyrosine-protein kinase. | NFKB inhibitor alpha. | 0.523 |
BTK | TICAM1 | ENSNLEP00000009167 | ENSNLEP00000016200 | Tyrosine-protein kinase. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.449 |
BTK | TIRAP | ENSNLEP00000009167 | ENSNLEP00000043926 | Tyrosine-protein kinase. | TIR domain containing adaptor protein. | 0.648 |
BTK | TLR2 | ENSNLEP00000009167 | ENSNLEP00000022789 | Tyrosine-protein kinase. | Toll-like receptor. | 0.468 |
BTK | TLR4 | ENSNLEP00000009167 | ENSNLEP00000025448 | Tyrosine-protein kinase. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.551 |
BTK | TLR6 | ENSNLEP00000009167 | ENSNLEP00000035326 | Tyrosine-protein kinase. | TIR domain-containing protein. | 0.472 |
CD14 | LY96 | ENSNLEP00000011329 | ENSNLEP00000030565 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lymphocyte antigen 96. | 0.972 |
CD14 | S100A8 | ENSNLEP00000011329 | ENSNLEP00000047219 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Protein S100; Belongs to the S-100 family. | 0.554 |
CD14 | S100A9 | ENSNLEP00000011329 | ENSNLEP00000012643 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Protein S100; Belongs to the S-100 family. | 0.489 |
CD14 | TLR1 | ENSNLEP00000011329 | ENSNLEP00000020714 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.480 |
CD14 | TLR2 | ENSNLEP00000011329 | ENSNLEP00000022789 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.979 |
CD14 | TLR3 | ENSNLEP00000011329 | ENSNLEP00000013896 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll like receptor 3; Belongs to the Toll-like receptor family. | 0.494 |
CD14 | TLR4 | ENSNLEP00000011329 | ENSNLEP00000025448 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.978 |
CD14 | TLR6 | ENSNLEP00000011329 | ENSNLEP00000035326 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | TIR domain-containing protein. | 0.459 |
CD36 | ENSNLEP00000028612 | ENSNLEP00000045275 | ENSNLEP00000028612 | CD36 molecule; Belongs to the CD36 family. | Uncharacterized protein. | 0.415 |
CD36 | ENSNLEP00000032011 | ENSNLEP00000045275 | ENSNLEP00000032011 | CD36 molecule; Belongs to the CD36 family. | Uncharacterized protein. | 0.415 |