STRINGSTRING
CHUK CHUK HMGB1 HMGB1 NFKBIA NFKBIA MYD88 MYD88 FGB FGB FGA FGA UNC93B1 UNC93B1 BTK BTK CD14 CD14 S100A9 S100A9 S100A1 S100A1 TLR3 TLR3 IKBKB IKBKB TICAM1 TICAM1 NFKB1 NFKB1 IKBKG IKBKG NFKB2 NFKB2 TRAF3 TRAF3 TLR10 TLR10 TLR1 TLR1 IRAK4 IRAK4 TLR2 TLR2 TLR4 TLR4 ENSNLEP00000028612 ENSNLEP00000028612 LY96 LY96 ENSNLEP00000032011 ENSNLEP00000032011 TLR6 TLR6 RELA RELA ENSNLEP00000036881 ENSNLEP00000036881 FGG FGG TIRAP TIRAP CD36 CD36 S100A8 S100A8 ENSNLEP00000047589 ENSNLEP00000047589
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
HMGB1High mobility group box 1. (215 aa)
NFKBIANFKB inhibitor alpha. (305 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
FGBFibrinogen beta chain. (491 aa)
FGAFibrinogen alpha chain. (863 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (597 aa)
BTKTyrosine-protein kinase. (659 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
S100A9Protein S100; Belongs to the S-100 family. (112 aa)
S100A1Protein S100; Belongs to the S-100 family. (146 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (691 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IKBKGNEMO domain-containing protein. (173 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TLR2Toll-like receptor. (784 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
ENSNLEP00000028612Uncharacterized protein. (134 aa)
LY96Lymphocyte antigen 96. (160 aa)
ENSNLEP00000032011Uncharacterized protein. (147 aa)
TLR6TIR domain-containing protein. (472 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
ENSNLEP00000036881Uncharacterized protein. (179 aa)
FGGFibrinogen gamma chain. (463 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
CD36CD36 molecule; Belongs to the CD36 family. (433 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
ENSNLEP00000047589Uncharacterized protein. (175 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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