61 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (404 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (267 aa)
	ENSNLEP00000043888	PRELI/MSF1 domain-containing protein. (208 aa)
	PIDD1	P53-induced death domain protein 1. (883 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (214 aa)
	ENSNLEP00000036398	Uncharacterized protein. (163 aa)
	TP53AIP1	Tumor protein p53 regulated apoptosis inducing protein 1. (123 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	BNIP3	Uncharacterized protein. (231 aa)
	LRCH3	Leucine rich repeats and calponin homology domain containing 3. (758 aa)
	NDRG2	NDRG family member 2. (375 aa)
	LOC101176263	PRELI/MSF1 domain-containing protein. (177 aa)
	ENSNLEP00000028943	PKS_ER domain-containing protein. (337 aa)
	PPP1R13B	Protein phosphatase 1 regulatory subunit 13B. (1071 aa)
	BNIP3L	BCL2 interacting protein 3 like. (219 aa)
	TNFRSF10A	TNF receptor superfamily member 10a. (471 aa)
	G1S167_NOMLE	Uncharacterized protein. (410 aa)
	NLRC4	NLR family CARD domain containing 4. (862 aa)
	TRIAP1	TP53 regulated inhibitor of apoptosis 1. (76 aa)
	RABGGTA	Rab geranylgeranyltransferase subunit alpha. (569 aa)
	LRCH2	Leucine rich repeats and calponin homology domain containing 2. (764 aa)
	STPG2	Sperm tail PG-rich repeat containing 2. (401 aa)
	RTN4IP1	Reticulon 4 interacting protein 1. (396 aa)
	VAT1L	Vesicle amine transport 1 like. (407 aa)
	PRELID1	PRELI domain containing 1. (219 aa)
	FAS	Fas cell surface death receptor. (335 aa)
	LRCH4	Calponin-homology (CH) domain-containing protein. (591 aa)
	AIFM2	Apoptosis inducing factor mitochondria associated 2. (306 aa)
	STEAP3	STEAP3 metalloreductase. (498 aa)
	CREBBP	CREB binding protein. (2442 aa)
	RABGGTB	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (331 aa)
	PRELID3B	PRELI domain containing 3B. (194 aa)
	CRYZ	Crystallin zeta. (329 aa)
	BCL6B	BCL6B transcription repressor. (478 aa)
	PRELID3A	PRELI domain containing 3A. (193 aa)
	G1R9J5_NOMLE	SAM domain-containing protein. (574 aa)
	TMEM219	Transmembrane protein 219. (240 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	NDRG3	NDRG family member 3. (388 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	NDRG1	N-myc downstream regulated 1. (394 aa)
	CRYZL1	Crystallin zeta like 1. (349 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (240 aa)
	NDRG4	NDRG family member 4. (391 aa)
	BCL2L14	BCL2 like 14. (355 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	LRCH1	Leucine rich repeats and calponin homology domain containing 1. (675 aa)
	BIRC5	Uncharacterized protein. (91 aa)
	AIFM3	Apoptosis inducing factor mitochondria associated 3. (605 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (346 aa)
	PERP	P53 apoptosis effector related to PMP22. (186 aa)
	CHM	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (655 aa)
	TP53BP2	Tumor protein p53 binding protein 2. (1136 aa)
	ENSNLEP00000024940	PKS_ER domain-containing protein. (288 aa)
	LOC100591137	PRELI/MSF1 domain-containing protein. (196 aa)
	ZNF623	Zinc finger protein 623. (529 aa)
	ZNF420	Uncharacterized protein. (627 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	ATM	ENSNLEP00000007362	ENSNLEP00000008823	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.416
APAF1	BCL2L14	ENSNLEP00000007362	ENSNLEP00000004207	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 14.	0.579
APAF1	BID	ENSNLEP00000007362	ENSNLEP00000036929	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.456
APAF1	BIRC5	ENSNLEP00000007362	ENSNLEP00000000106	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.691
APAF1	CASP1	ENSNLEP00000007362	ENSNLEP00000044525	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 1; Belongs to the peptidase C14A family.	0.837
APAF1	CASP10	ENSNLEP00000007362	ENSNLEP00000008472	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 10; Belongs to the peptidase C14A family.	0.805
APAF1	CASP2	ENSNLEP00000007362	ENSNLEP00000003849	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 2; Belongs to the peptidase C14A family.	0.855
APAF1	CASP6	ENSNLEP00000007362	ENSNLEP00000020118	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 6; Belongs to the peptidase C14A family.	0.816
APAF1	CRADD	ENSNLEP00000007362	ENSNLEP00000040070	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.566
APAF1	FAS	ENSNLEP00000007362	ENSNLEP00000014908	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas cell surface death receptor.	0.459
APAF1	G1R9J5_NOMLE	ENSNLEP00000007362	ENSNLEP00000009887	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	SAM domain-containing protein.	0.617
APAF1	G1S167_NOMLE	ENSNLEP00000007362	ENSNLEP00000019253	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.515
APAF1	NLRC4	ENSNLEP00000007362	ENSNLEP00000019081	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	NLR family CARD domain containing 4.	0.535
APAF1	PIDD1	ENSNLEP00000007362	ENSNLEP00000042914	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	P53-induced death domain protein 1.	0.555
APAF1	TNFRSF10A	ENSNLEP00000007362	ENSNLEP00000019277	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	TNF receptor superfamily member 10a.	0.513
APAF1	TP63	ENSNLEP00000007362	ENSNLEP00000032932	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.617
ATM	APAF1	ENSNLEP00000008823	ENSNLEP00000007362	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.416
ATM	G1R9J5_NOMLE	ENSNLEP00000008823	ENSNLEP00000009887	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SAM domain-containing protein.	0.829
ATM	PIDD1	ENSNLEP00000008823	ENSNLEP00000042914	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.729
ATM	TP63	ENSNLEP00000008823	ENSNLEP00000032932	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.829

page 1 of 12

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About