STRINGSTRING
NRAS NRAS PTPN11 PTPN11 FGF22 FGF22 KL KL FGF23 FGF23 FGF6 FGF6 FRS3 FRS3 KRAS KRAS HRAS HRAS FGF5 FGF5 FGF1 FGF1 FGF3 FGF3 FGFR1 FGFR1 FGF9 FGF9 FGF8 FGF8 SOS1 SOS1 ENSNLEP00000043688 ENSNLEP00000043688 ERAS ERAS ENSNLEP00000024736 ENSNLEP00000024736 FGF20 FGF20 ENSNLEP00000027584 ENSNLEP00000027584 FGF10 FGF10 LOC100605369 LOC100605369 FRS2 FRS2 GRB2 GRB2 FGF2 FGF2 CSDE1 CSDE1 FGF17 FGF17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASNRAS proto-oncogene, GTPase. (189 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
KLKlotho. (855 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
ERASES cell expressed Ras. (233 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC100605369Uncharacterized protein. (571 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
CSDE1Cold shock domain containing E1. (844 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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