STRINGSTRING
NRAS NRAS ENSNLEP00000043688 ENSNLEP00000043688 GRB2 GRB2 PTPN11 PTPN11 G1QHL5_NOMLE G1QHL5_NOMLE FGF16 FGF16 FGF23 FGF23 FRS3 FRS3 KRAS KRAS GAB1 GAB1 PIK3CA PIK3CA PLCG1 PLCG1 HRAS HRAS FGF5 FGF5 FGF1 FGF1 SHC1 SHC1 FGF9 FGF9 FGF8 FGF8 SOS1 SOS1 ERAS ERAS ENSNLEP00000024736 ENSNLEP00000024736 FGFR3 FGFR3 FGF20 FGF20 ENSNLEP00000027584 ENSNLEP00000027584 PIK3R1 PIK3R1 LOC100605369 LOC100605369 FRS2 FRS2 FGF2 FGF2 CSDE1 CSDE1 ENSNLEP00000046563 ENSNLEP00000046563 ENSNLEP00000039370 ENSNLEP00000039370 FGF17 FGF17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SHC1SHC adaptor protein 1. (542 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
ERASES cell expressed Ras. (233 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
LOC100605369Uncharacterized protein. (571 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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