STRINGSTRING
PIK3R1 PIK3R1 MKNK1 MKNK1 FGF10 FGF10 SPRY2 SPRY2 SPRED1 SPRED1 ENSNLEP00000027584 ENSNLEP00000027584 MAPK1 MAPK1 FGF20 FGF20 ENSNLEP00000024736 ENSNLEP00000024736 RPS27A-2 RPS27A-2 ERAS ERAS SOS1 SOS1 FGF8 FGF8 FGF9 FGF9 FGFR1 FGFR1 PPP2CB PPP2CB SHC1 SHC1 FGF3 FGF3 FGF1 FGF1 ANOS1 ANOS1 SPRED2 SPRED2 NRAS NRAS GRB2 GRB2 PPP2CA PPP2CA ENSNLEP00000043688 ENSNLEP00000043688 RPS27A RPS27A ENSNLEP00000046563 ENSNLEP00000046563 FLRT3 FLRT3 SRC SRC FGF5 FGF5 HRAS HRAS CBL CBL PLCG1 PLCG1 PIK3CA PIK3CA FNDC3B FNDC3B GAB1 GAB1 KRAS KRAS FRS3 FRS3 FGF6 FGF6 FGF23 FGF23 BRAF BRAF MKNK2 MKNK2 MAPK3 MAPK3 KL KL G1QJR7_NOMLE G1QJR7_NOMLE FGF22 FGF22 G1QHL5_NOMLE G1QHL5_NOMLE PTPN11 PTPN11 FGF17 FGF17 ENSNLEP00000039370 ENSNLEP00000039370 FNDC3A FNDC3A ENSNLEP00000038869 ENSNLEP00000038869 ENSNLEP00000038579 ENSNLEP00000038579 CSDE1 CSDE1 ENSNLEP00000037583 ENSNLEP00000037583 FGF2 FGF2 PPP2R1A PPP2R1A FRS2 FRS2 FLRT1 FLRT1 LOC100605369 LOC100605369 ENSNLEP00000034619 ENSNLEP00000034619 FLRT2 FLRT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (463 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY2Sprouty RTK signaling antagonist 2. (338 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
RPS27A-2Ubiquitin-like domain-containing protein. (156 aa)
ERASES cell expressed Ras. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SHC1SHC adaptor protein 1. (542 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ANOS1Anosmin 1. (680 aa)
SPRED2Sprouty related EVH1 domain containing 2. (418 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
RPS27AUbiquitin-like domain-containing protein. (161 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
SRCTyrosine-protein kinase. (537 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CBLCbl proto-oncogene. (905 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
MKNK2Uncharacterized protein. (272 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
KLKlotho. (855 aa)
G1QJR7_NOMLEUncharacterized protein. (420 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSNLEP00000038869Ubiquitin-like domain-containing protein. (156 aa)
ENSNLEP00000038579Ubiquitin-like domain-containing protein. (104 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSNLEP00000037583Ubiquitin-like domain-containing protein. (79 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
FLRT1Fibronectin type-III domain-containing protein. (452 aa)
LOC100605369Uncharacterized protein. (571 aa)
ENSNLEP00000034619Ubiquitin-like domain-containing protein. (77 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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