STRINGSTRING
VCAM1 VCAM1 GLMP GLMP RORC RORC HIF1A HIF1A LOC100603153 LOC100603153 TNF TNF FOS FOS IL6 IL6 HMOX1 HMOX1 CD36 CD36 POU2F1 POU2F1 OPRM1 OPRM1 HSPA8 HSPA8 IL1B IL1B IL23R IL23R MAOA MAOA LAMA5 LAMA5 CCL22 CCL22 S1PR1 S1PR1 BCL6 BCL6 IL18 IL18 FGF2 FGF2 SOCS5 SOCS5 BCL2 BCL2 RORA RORA IL6R IL6R ZEB2 ZEB2 JUNB JUNB STAT1 STAT1 IL10 IL10 PIK3R1 PIK3R1 LCN2 LCN2 CCND1 CCND1 RHOU RHOU ENSNLEP00000031324 ENSNLEP00000031324 ITGB1 ITGB1 IL13 IL13 AKT1 AKT1 HSP90AA1 HSP90AA1 FSCN1 FSCN1 HGF HGF FOXO3 FOXO3 SOX2 SOX2 SOCS1 SOCS1 ZEB1 ZEB1 PTGS2 PTGS2 SAA1 SAA1 SAA2 SAA2 IL23A IL23A STAT6 STAT6 ALOX15 ALOX15 BATF BATF ITGAX ITGAX ITGAM ITGAM ALOX5 ALOX5 COL1A2 COL1A2 FASLG FASLG JAK1 JAK1 NANOG NANOG IL13RA1 IL13RA1 IL13RA2 IL13RA2 TGFB1 TGFB1 IL4 IL4 VIM VIM TYK2 TYK2 ICAM1 ICAM1 GATA3 GATA3 MUC1 MUC1 IL4R IL4R F13A1 F13A1 STAT3 STAT3 PIM1 PIM1 IRF4 IRF4 MCL1 MCL1 OPRD1 OPRD1 TNFRSF1B TNFRSF1B FOXS1 FOXS1 BCL2L1 BCL2L1 BCL6B BCL6B JAK2 JAK2 PIM2 PIM2 MMP3 MMP3 MMP1 MMP1 MMP9 MMP9 HSP90B1 HSP90B1 LBP LBP JAK3 JAK3 MYC MYC G1QZW6_NOMLE G1QZW6_NOMLE IL12A IL12A IL12B IL12B IL17A IL17A IL17F IL17F OSM OSM LIF LIF ITGB2 ITGB2 IL1A IL1A NOS2 NOS2 CCL11 CCL11 G1QLB3_NOMLE G1QLB3_NOMLE ANXA1 ANXA1 MMP2 MMP2 IL2RG IL2RG LOC100584814 LOC100584814 FOXO1 FOXO1 POMC POMC BIRC5 BIRC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCAM1Vascular cell adhesion molecule 1. (739 aa)
GLMPGlycosylated lysosomal membrane protein. (369 aa)
RORCRAR related orphan receptor C. (511 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
LOC100603153Uncharacterized protein. (445 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL6Uncharacterized protein. (258 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
CD36CD36 molecule; Belongs to the CD36 family. (433 aa)
POU2F1POU domain protein. (755 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL23RInterleukin 23 receptor. (629 aa)
MAOAAmine oxidase. (527 aa)
LAMA5Laminin subunit alpha 5. (3418 aa)
CCL22C-C motif chemokine. (93 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
BCL6BCL6 transcription repressor. (706 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
RORARAR related orphan receptor A. (555 aa)
IL6RInterleukin 6 receptor. (420 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (327 aa)
STAT1Signal transducer and activator of transcription. (780 aa)
IL10Interleukin 10. (178 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
RHOURas homolog family member U. (258 aa)
ENSNLEP00000031324Uncharacterized protein. (255 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
IL13Interleukin 13. (146 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
FSCN1Uncharacterized protein. (274 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
FOXO3Forkhead box O3. (672 aa)
SOX2SRY-box transcription factor 2. (319 aa)
SOCS1Suppressor of cytokine signaling 1. (208 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1105 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
ALOX15Arachidonate 15-lipoxygenase. (662 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1153 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (992 aa)
ALOX5Arachidonate 5-lipoxygenase. (655 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
NANOGHomeobox domain-containing protein. (305 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (425 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (380 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (135 aa)
VIMIF rod domain-containing protein; Belongs to the intermediate filament family. (228 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
GATA3GATA binding protein 3. (444 aa)
MUC1Mucin 1, cell surface associated. (483 aa)
IL4RInterleukin 4 receptor. (810 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
IRF4Interferon regulatory factor 4. (451 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
OPRD1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (265 aa)
TNFRSF1BTNF receptor superfamily member 1B. (424 aa)
FOXS1Forkhead box S1. (278 aa)
BCL2L1BCL2 like 1. (217 aa)
BCL6BBCL6B transcription repressor. (478 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
MMP1Matrix metallopeptidase 1. (470 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
LBPLipopolysaccharide binding protein. (481 aa)
JAK3Tyrosine-protein kinase. (1025 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
G1QZW6_NOMLEHomeobox domain-containing protein. (247 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (203 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
IL17AInterleukin 17A. (155 aa)
IL17FInterleukin 17F. (163 aa)
OSMOncostatin M. (252 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ITGB2Integrin beta. (762 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (247 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
CCL11C-C motif chemokine. (97 aa)
G1QLB3_NOMLEC-C motif chemokine. (138 aa)
ANXA1Annexin. (346 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
LOC100584814C-type lectin domain-containing protein. (190 aa)
FOXO1Forkhead box O1. (652 aa)
POMCProopiomelanocortin. (243 aa)
BIRC5Uncharacterized protein. (91 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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