STRINGSTRING
CHEK2 CHEK2 CDK3 CDK3 RFFL RFFL PHF20 PHF20 PPP2CB PPP2CB SGK1 SGK1 CCNA1 CCNA1 RNF34 RNF34 RICTOR RICTOR RPS27A-2 RPS27A-2 MDM4 MDM4 AKT3 AKT3 ENSNLEP00000024590 ENSNLEP00000024590 PPP2R5C PPP2R5C AKT1 AKT1 CDK1 CDK1 PPP2R1B PPP2R1B CDK2 CDK2 MTOR MTOR ENSNLEP00000034619 ENSNLEP00000034619 PPP2R1A PPP2R1A MLST8 MLST8 ENSNLEP00000037583 ENSNLEP00000037583 MDM2 MDM2 ENSNLEP00000038579 ENSNLEP00000038579 TXNDC11 TXNDC11 USP7 USP7 TP53 TP53 LOC100592336 LOC100592336 CCNA2 CCNA2 USP2 USP2 ENSNLEP00000038869 ENSNLEP00000038869 ENSNLEP00000039422 ENSNLEP00000039422 PRR5 PRR5 LOC100593010 LOC100593010 PPP2CA PPP2CA AKT2 AKT2 RPS27A RPS27A MAPKAP1 MAPKAP1 ATM ATM KXD1 KXD1 CCNG1 CCNG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHEK2Checkpoint kinase 2. (487 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (270 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (363 aa)
PHF20PHD finger protein 20. (1012 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RNF34Uncharacterized protein. (477 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1709 aa)
RPS27A-2Ubiquitin-like domain-containing protein. (156 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSNLEP00000024590Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (479 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (311 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
ENSNLEP00000034619Ubiquitin-like domain-containing protein. (77 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
ENSNLEP00000037583Ubiquitin-like domain-containing protein. (79 aa)
MDM2MDM2 proto-oncogene. (501 aa)
ENSNLEP00000038579Ubiquitin-like domain-containing protein. (104 aa)
TXNDC11Thioredoxin domain containing 11. (883 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (361 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (577 aa)
ENSNLEP00000038869Ubiquitin-like domain-containing protein. (156 aa)
ENSNLEP00000039422Ubiquitin-like domain-containing protein. (136 aa)
PRR5Proline rich 5. (410 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
RPS27AUbiquitin-like domain-containing protein. (161 aa)
MAPKAP1MAPK associated protein 1. (523 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3055 aa)
KXD1KxDL motif containing 1. (195 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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