STRINGSTRING
PTK2 PTK2 COL11A2 COL11A2 ARF6 ARF6 HPN HPN PIK3R1 PIK3R1 ITGB1 ITGB1 LAMC2 LAMC2 RAP1B RAP1B ENSNLEP00000029691 ENSNLEP00000029691 SPINT1 SPINT1 ENSNLEP00000027935 ENSNLEP00000027935 ENSNLEP00000027584 ENSNLEP00000027584 ENSNLEP00000027513 ENSNLEP00000027513 HGFAC HGFAC ENSNLEP00000025390 ENSNLEP00000025390 ENSNLEP00000024736 ENSNLEP00000024736 MET MET HGF HGF RPS27A-2 RPS27A-2 ERAS ERAS LAMC1 LAMC1 COL2A1 COL2A1 TNS2 TNS2 SPINT2 SPINT2 SOS1 SOS1 COL27A1 COL27A1 RAC1 RAC1 COL1A2 COL1A2 DOCK7 DOCK7 PTPRJ PTPRJ PTPN11 PTPN11 CRKL CRKL CRK CRK GGA3 GGA3 RANBP9 RANBP9 LAMB3 LAMB3 TNS4 TNS4 SH3GL1 SH3GL1 RAP1A RAP1A TNS3 TNS3 KRAS KRAS GAB1 GAB1 FNDC3B FNDC3B PIK3CA PIK3CA USP8 USP8 COL3A1 COL3A1 COL5A2 COL5A2 LAMA3 LAMA3 LAMA1 LAMA1 FN1 FN1 TNS1 TNS1 CBL CBL LRIG1 LRIG1 HRAS HRAS LAMB1 LAMB1 ITGA3 ITGA3 COL1A1 COL1A1 SH3KBP1 SH3KBP1 COL24A1 COL24A1 SH3GL3 SH3GL3 STAM2 STAM2 STAT3 STAT3 SHC1 SHC1 COL11A1 COL11A1 COL5A3 COL5A3 LAMC3 LAMC3 RAPGEF1 RAPGEF1 LAMA4 LAMA4 HGS HGS RAB4B RAB4B SRC SRC ENSNLEP00000048405 ENSNLEP00000048405 SH3GL2 SH3GL2 LOC101176233 LOC101176233 ENSNLEP00000046563 ENSNLEP00000046563 STAM STAM LOC101175949 LOC101175949 RANBP10 RANBP10 PTPN2 PTPN2 LOC101178025 LOC101178025 EPS15 EPS15 GRB2 GRB2 RPS27A RPS27A ENSNLEP00000044084 ENSNLEP00000044084 ENSNLEP00000043688 ENSNLEP00000043688 ENSNLEP00000042609 ENSNLEP00000042609 ITGA2 ITGA2 ENSNLEP00000042424 ENSNLEP00000042424 ENSNLEP00000042160 ENSNLEP00000042160 LAMA5 LAMA5 MEGF11 MEGF11 RAB4A RAB4A NRAS NRAS ENSNLEP00000039370 ENSNLEP00000039370 FNDC3A FNDC3A ENSNLEP00000038869 ENSNLEP00000038869 ENSNLEP00000038579 ENSNLEP00000038579 CSDE1 CSDE1 ENSNLEP00000037583 ENSNLEP00000037583 ENSNLEP00000036455 ENSNLEP00000036455 LAMA2 LAMA2 LOC100581909 LOC100581909 LOC100605369 LOC100605369 ENSNLEP00000034619 ENSNLEP00000034619
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
COL11A2Fibrillar collagen NC1 domain-containing protein. (1338 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
HPNHepsin; Belongs to the peptidase S1 family. (431 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LAMC2Laminin subunit gamma 2. (1178 aa)
RAP1BRAP1B, member of RAS oncogene family. (165 aa)
ENSNLEP00000029691SH3 domain-containing protein. (370 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (530 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
ENSNLEP00000027513Uncharacterized protein. (154 aa)
HGFACHGF activator. (661 aa)
ENSNLEP00000025390Tyrosine-protein phosphatase non-receptor type. (391 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
RPS27A-2Ubiquitin-like domain-containing protein. (156 aa)
ERASES cell expressed Ras. (233 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
TNS2Tensin 2. (1361 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
COL27A1Collagen type XXVII alpha 1 chain. (1787 aa)
RAC1Rac family small GTPase 1. (187 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2104 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1282 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CRKUncharacterized protein. (252 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (677 aa)
RANBP9Uncharacterized protein. (593 aa)
LAMB3Laminin subunit beta 3. (1137 aa)
TNS4Tensin 4. (703 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (330 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
TNS3Tensin 3. (1402 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1117 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
LAMA3Laminin subunit alpha 3. (3316 aa)
LAMA1Laminin subunit alpha 1. (3033 aa)
FN1Fibronectin 1. (2477 aa)
TNS1Tensin 1. (1696 aa)
CBLCbl proto-oncogene. (905 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1089 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1050 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (629 aa)
COL24A1Collagen type XXIV alpha 1 chain. (1709 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
STAM2Signal transducing adaptor molecule 2. (523 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SHC1SHC adaptor protein 1. (542 aa)
COL11A1Collagen type XI alpha 1 chain. (1800 aa)
COL5A3Collagen type V alpha 3 chain. (1693 aa)
LAMC3Laminin subunit gamma 3. (1550 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1110 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (774 aa)
RAB4BUncharacterized protein. (181 aa)
SRCTyrosine-protein kinase. (537 aa)
ENSNLEP00000048405Uncharacterized protein. (167 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
LOC101176233Uncharacterized protein. (880 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
STAMSignal transducing adaptor molecule. (540 aa)
LOC101175949Uncharacterized protein. (206 aa)
RANBP10RAN binding protein 10. (655 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
LOC101178025SH3 domain-containing protein. (369 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (899 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RPS27AUbiquitin-like domain-containing protein. (161 aa)
ENSNLEP00000044084Fibrillar collagen NC1 domain-containing protein. (1527 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
ENSNLEP00000042424Tyrosine-protein phosphatase non-receptor type. (405 aa)
ENSNLEP00000042160Tyrosine-protein phosphatase non-receptor type. (386 aa)
LAMA5Laminin subunit alpha 5. (3418 aa)
MEGF11Multiple EGF like domains 11. (1140 aa)
RAB4ARAB4A, member RAS oncogene family. (218 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSNLEP00000038869Ubiquitin-like domain-containing protein. (156 aa)
ENSNLEP00000038579Ubiquitin-like domain-containing protein. (104 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSNLEP00000037583Ubiquitin-like domain-containing protein. (79 aa)
ENSNLEP00000036455Uncharacterized protein. (127 aa)
LAMA2Laminin subunit alpha 2. (3062 aa)
LOC100581909Uncharacterized protein. (510 aa)
LOC100605369Uncharacterized protein. (571 aa)
ENSNLEP00000034619Ubiquitin-like domain-containing protein. (77 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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