STRINGSTRING
IL1RL1 IL1RL1 CD276 CD276 ESR2 ESR2 PPP2R5E PPP2R5E PIK3AP1 PIK3AP1 INS-IGF2 INS-IGF2 FGF9 FGF9 PIP4K2A PIP4K2A FGFR4 FGFR4 FGFR1 FGFR1 PPP2CB PPP2CB CD19 CD19 FGF3 FGF3 FGF19 FGF19 PDGFRB PDGFRB TGFA TGFA FGF1 FGF1 SPEM1 SPEM1 PIK3CD PIK3CD HBEGF HBEGF NRG2 NRG2 IL33 IL33 RELCH RELCH FGF5 FGF5 KIT KIT PDGFRA PDGFRA PDGFA PDGFA PIP5K1B PIP5K1B BTC BTC EREG EREG GAB4 GAB4 ERBB4 ERBB4 ICOS ICOS CD28 CD28 PPP4R1 PPP4R1 FGF7 FGF7 PIK3R2 PIK3R2 PIK3CA PIK3CA FNDC3B FNDC3B KITLG KITLG IER3 IER3 PPP2R5B PPP2R5B GAB1 GAB1 MYD88 MYD88 FLT3LG FLT3LG RAC1 RAC1 STRN STRN FGF17 FGF17 AREG AREG GRB2 GRB2 ENSNLEP00000040897 ENSNLEP00000040897 FYN FYN ENSNLEP00000041179 ENSNLEP00000041179 PPP2CA PPP2CA PIP5K1A PIP5K1A ENSNLEP00000041829 ENSNLEP00000041829 RAC2 RAC2 INSC INSC ENSNLEP00000042609 ENSNLEP00000042609 MORN2 MORN2 ENSNLEP00000043688 ENSNLEP00000043688 NRG4 NRG4 PIK3R3 PIK3R3 PIP5K1C PIP5K1C NRG1 NRG1 BANK1 BANK1 IRS2 IRS2 NRG3 NRG3 ERBB3 ERBB3 EPGN EPGN EGF EGF GAB2 GAB2 FGFR2 FGFR2 KLB KLB FGF20 FGF20 PPP2R5C PPP2R5C VAV1 VAV1 MAPK1 MAPK1 ENSNLEP00000027432 ENSNLEP00000027432 ENSNLEP00000027584 ENSNLEP00000027584 ENSNLEP00000027935 ENSNLEP00000027935 AKT1 AKT1 FGF10 FGF10 PIK3R1 PIK3R1 PPP2R1B PPP2R1B ENSNLEP00000032399 ENSNLEP00000032399 LOC100605369 LOC100605369 IRS1 IRS1 EGFR EGFR PPP2R5A PPP2R5A RHOG RHOG FRS2 FRS2 PIP4K2C PIP4K2C IL1RAP IL1RAP STRN3 STRN3 SRC SRC ERBB2 ERBB2 FGF2 FGF2 FNDC3A FNDC3A ENSNLEP00000039390 ENSNLEP00000039390 FNBP4 FNBP4 CD80 CD80 PPP2R5D PPP2R5D PIK3CB PIK3CB TRAT1 TRAT1 WDR64 WDR64 FGF6 FGF6 FGF23 FGF23 STRN4 STRN4 LCK LCK MAPK3 MAPK3 FAM102B FAM102B KL KL FGF16 FGF16 FGF22 FGF22 PIP4K2B PIP4K2B PPP2R1A PPP2R1A INSR INSR FLT3 FLT3 G1QHL5_NOMLE G1QHL5_NOMLE CD86 CD86 PTPN11 PTPN11 PIP5KL1 PIP5KL1 FAM102A FAM102A IRAK4 IRAK4 PPP4R4 PPP4R4 TRAF6 TRAF6 HGF HGF ENSNLEP00000024590 ENSNLEP00000024590 MET MET ENSNLEP00000024736 ENSNLEP00000024736 FGFR3 FGFR3 LOC100599403 LOC100599403 FGF8 FGF8 PDGFB PDGFB ESR1 ESR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1RL1Uncharacterized protein. (460 aa)
CD276Uncharacterized protein. (299 aa)
ESR2Estrogen receptor 2. (530 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (447 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (371 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CD19CD19 molecule. (558 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TGFATransforming growth factor alpha. (166 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SPEM1Spermatid maturation 1. (309 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
NRG2Uncharacterized protein. (597 aa)
IL33Interleukin 33. (270 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1219 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1046 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (572 aa)
BTCBetacellulin. (178 aa)
EREGEpiregulin. (169 aa)
GAB4GRB2 associated binding protein family member 4. (575 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ICOSInducible T cell costimulator. (199 aa)
CD28CD28 molecule. (220 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (950 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PIK3R2Uncharacterized protein. (727 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
IER3Immediate early response 3. (147 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (424 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
FLT3LGUncharacterized protein. (223 aa)
RAC1Rac family small GTPase 1. (187 aa)
STRNStriatin. (702 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
AREGEGF-like domain-containing protein. (274 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSNLEP00000040897Uncharacterized protein. (331 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSNLEP00000041179Spem1 domain-containing protein. (269 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ENSNLEP00000041829PIPK domain-containing protein. (329 aa)
RAC2Rac family small GTPase 2. (192 aa)
INSCINSC spindle orientation adaptor protein. (569 aa)
ENSNLEP00000042609Uncharacterized protein. (168 aa)
MORN2MORN repeat containing 2. (79 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
NRG4Neuregulin 4. (117 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PIP5K1CPIPK domain-containing protein. (759 aa)
NRG1Neuregulin 1. (713 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (785 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
NRG3Neuregulin 3. (720 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
EPGNEpithelial mitogen. (154 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
GAB2GRB2 associated binding protein 2. (651 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
KLBKlotho beta. (1044 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (579 aa)
VAV1Uncharacterized protein. (739 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
ENSNLEP00000027432TNF receptor-associated factor. (488 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
ENSNLEP00000027935Uncharacterized protein. (181 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
LOC100605369Uncharacterized protein. (571 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
RHOGRas homolog family member G. (191 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
STRN3Striatin 3. (797 aa)
SRCTyrosine-protein kinase. (537 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSNLEP00000039390Protein kinase domain-containing protein. (673 aa)
FNBP4Formin binding protein 4. (1022 aa)
CD80CD80 molecule. (288 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (607 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (186 aa)
WDR64WD repeat domain 64. (1052 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
STRN4Striatin 4. (713 aa)
LCKLCK proto-oncogene, Src family tyrosine kinase. (448 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
FAM102BFamily with sequence similarity 102 member B. (314 aa)
KLKlotho. (855 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
INSRInsulin receptor. (1232 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
CD86CD86 molecule. (329 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (394 aa)
FAM102AFamily with sequence similarity 102 member A. (337 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (855 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ENSNLEP00000024590Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (479 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
LOC100599403PIPK domain-containing protein. (591 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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