(63 nodes) DNA Damage Bypass network (Nomascus leucogenys)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RFC5	Replication factor C subunit 5. (354 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (759 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	G1QMF3_NOMLE	B30.2/SPRY domain-containing protein. (531 aa)
	SPRTN	SprT-like N-terminal domain. (483 aa)
	DDB1	Damage specific DNA binding protein 1. (1139 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	RAD18	RAD18 E3 ubiquitin protein ligase. (494 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (808 aa)
	WDR48	WD repeat domain 48. (677 aa)
	POLD1	DNA polymerase. (1062 aa)
	ATAD5	ATPase family AAA domain containing 5. (1823 aa)
	SPATA5L1	AAA domain-containing protein. (171 aa)
	KXD1	KxDL motif containing 1. (195 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	UBA7	Ubiquitin like modifier activating enzyme 7. (969 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	SPATA5	Spermatogenesis associated 5. (879 aa)
	MAD2L2	HORMA domain-containing protein. (124 aa)
	USP43	Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1123 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1313 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3107 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1250 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	RFC1	Replication factor C subunit 1. (1130 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	RPS27A-2	Ubiquitin-like domain-containing protein. (156 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
	ENSNLEP00000046515	Uncharacterized protein. (117 aa)
	ENSNLEP00000034619	Ubiquitin-like domain-containing protein. (77 aa)
	LOC100579303	UmuC domain-containing protein. (646 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (116 aa)
	ENSNLEP00000032264	B30.2/SPRY domain-containing protein. (414 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (261 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2264 aa)
	PCLAF	PAF domain-containing protein. (115 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	POLD4	Uncharacterized protein. (51 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (161 aa)
	RFC2	Replication factor C subunit 2. (322 aa)
	LOC100580418	Uncharacterized protein. (112 aa)
	POLK	DNA polymerase kappa. (896 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (703 aa)
	RPA3	Replication protein A3. (121 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (312 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (913 aa)
	ENSNLEP00000039422	Ubiquitin-like domain-containing protein. (136 aa)
	ENSNLEP00000038869	Ubiquitin-like domain-containing protein. (156 aa)
	ENSNLEP00000038579	Ubiquitin-like domain-containing protein. (104 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (498 aa)
	NPLOC4	NPL4 homolog, ubiquitin recognition factor. (607 aa)
	ENSNLEP00000037583	Ubiquitin-like domain-containing protein. (79 aa)
	RBX1	Ring-box 1. (108 aa)
	UBE2L6	Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	ENSNLEP00000027752	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (243 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (556 aa)
	POLD3	Uncharacterized protein. (463 aa)
	POLI	DNA polymerase iota. (660 aa)
	ENSNLEP00000025290	Uncharacterized protein. (239 aa)
	POLH	DNA polymerase eta. (698 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CUL4A	ENSNLEP00000007107	ENSNLEP00000000861	ATPase family AAA domain containing 5.	Cullin 4A; Belongs to the cullin family.	0.504
ATAD5	CUL4B	ENSNLEP00000007107	ENSNLEP00000042782	ATPase family AAA domain containing 5.	Cullin 4B; Belongs to the cullin family.	0.504
ATAD5	DDB1	ENSNLEP00000007107	ENSNLEP00000002855	ATPase family AAA domain containing 5.	Damage specific DNA binding protein 1.	0.579
ATAD5	DTL	ENSNLEP00000007107	ENSNLEP00000043385	ATPase family AAA domain containing 5.	Denticleless E3 ubiquitin protein ligase homolog.	0.810
ATAD5	ENSNLEP00000025290	ENSNLEP00000007107	ENSNLEP00000025290	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.509
ATAD5	ENSNLEP00000027752	ENSNLEP00000007107	ENSNLEP00000027752	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.895
ATAD5	ENSNLEP00000046515	ENSNLEP00000007107	ENSNLEP00000046515	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.432
ATAD5	LOC100579303	ENSNLEP00000007107	ENSNLEP00000034315	ATPase family AAA domain containing 5.	UmuC domain-containing protein.	0.531
ATAD5	LOC100580418	ENSNLEP00000007107	ENSNLEP00000043681	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.432
ATAD5	MAD2L2	ENSNLEP00000007107	ENSNLEP00000011740	ATPase family AAA domain containing 5.	HORMA domain-containing protein.	0.628
ATAD5	MEIOB	ENSNLEP00000007107	ENSNLEP00000010769	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.714
ATAD5	PCLAF	ENSNLEP00000007107	ENSNLEP00000045571	ATPase family AAA domain containing 5.	PAF domain-containing protein.	0.498
ATAD5	PCNA	ENSNLEP00000007107	ENSNLEP00000009397	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.895
ATAD5	POLD1	ENSNLEP00000007107	ENSNLEP00000006841	ATPase family AAA domain containing 5.	DNA polymerase.	0.780
ATAD5	POLD2	ENSNLEP00000007107	ENSNLEP00000038398	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.673
ATAD5	POLE	ENSNLEP00000007107	ENSNLEP00000029643	ATPase family AAA domain containing 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.842
ATAD5	POLE2	ENSNLEP00000007107	ENSNLEP00000014625	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.801
ATAD5	POLE3	ENSNLEP00000007107	ENSNLEP00000020276	ATPase family AAA domain containing 5.	DNA polymerase epsilon 3, accessory subunit.	0.715
ATAD5	POLE4	ENSNLEP00000007107	ENSNLEP00000034103	ATPase family AAA domain containing 5.	DNA polymerase epsilon 4, accessory subunit.	0.679
ATAD5	POLH	ENSNLEP00000007107	ENSNLEP00000024875	ATPase family AAA domain containing 5.	DNA polymerase eta.	0.608

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