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GAB4 GAB4 HRAS HRAS FGF5 FGF5 ATP6V0C ATP6V0C LOC100592336 LOC100592336 SPEM1 SPEM1 TRIB3 TRIB3 FGF1 FGF1 ATP6V1B1 ATP6V1B1 THEM4 THEM4 FGF19 FGF19 FGF3 FGF3 SHC1 SHC1 ATP6V0A1 ATP6V0A1 FGFR1 FGFR1 FGFR4 FGFR4 ATP6AP1L ATP6AP1L FGF9 FGF9 INS-IGF2 INS-IGF2 ATP6V0A4 ATP6V0A4 ATP6AP1 ATP6AP1 FGF8 FGF8 NRDC NRDC SOS1 SOS1 GAB2 GAB2 ATP6V1G1 ATP6V1G1 FGFR2 FGFR2 KLB KLB PDE3B PDE3B ERAS ERAS ENSNLEP00000024736 ENSNLEP00000024736 FGFR3 FGFR3 ENSNLEP00000024927 ENSNLEP00000024927 ATP6V0B ATP6V0B FGF20 FGF20 ATP6V1C2 ATP6V1C2 MAPK1 MAPK1 ENSNLEP00000027584 ENSNLEP00000027584 ATP6V1G2 ATP6V1G2 FGF10 FGF10 PIK3C3 PIK3C3 ATP6V1G3 ATP6V1G3 ATP6V0E1 ATP6V0E1 PIK3R1 PIK3R1 ENSNLEP00000032219 ENSNLEP00000032219 ENSNLEP00000032399 ENSNLEP00000032399 LOC100605369 LOC100605369 IRS1 IRS1 PIK3R4 PIK3R4 FRS2 FRS2 MAPK3 MAPK3 ATP6V0A2 ATP6V0A2 FGF23 FGF23 FGF6 FGF6 ATP6V1C1 ATP6V1C1 CNST CNST ATP6V0D1 ATP6V0D1 ENSNLEP00000043688 ENSNLEP00000043688 FGF2 FGF2 ATP6V1E1 ATP6V1E1 ENSNLEP00000045775 ENSNLEP00000045775 IRS2 IRS2 ENSNLEP00000046563 ENSNLEP00000046563 ATP6V0D2 ATP6V0D2 KL KL FGF16 FGF16 ATP6V1B2 ATP6V1B2 FGF22 FGF22 INSR INSR FLT3 FLT3 G1QHL5_NOMLE G1QHL5_NOMLE PTPN11 PTPN11 GRB10 GRB10 ENSNLEP00000039370 ENSNLEP00000039370 FGF17 FGF17 NRAS NRAS LOC100593010 LOC100593010 GRB2 GRB2 ENSNLEP00000041179 ENSNLEP00000041179 IDE IDE AKT2 AKT2 ATP6V1D ATP6V1D PTPRF PTPRF ATP6V1F ATP6V1F ATP6V0E2 ATP6V0E2 CTSD CTSD ATP6V1H ATP6V1H PIK3CB PIK3CB ATP6V1A ATP6V1A FLT3LG FLT3LG KRAS KRAS GAB1 GAB1 PIK3CA PIK3CA LIM2 LIM2 PIK3R2 PIK3R2 FGF7 FGF7 TCIRG1 TCIRG1 G1R620_NOMLE G1R620_NOMLE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAB4GRB2 associated binding protein family member 4. (575 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
SPEM1Spermatid maturation 1. (309 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ATP6V1B1ATPase H+ transporting V1 subunit B1. (483 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
SHC1SHC adaptor protein 1. (542 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (825 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
ATP6AP1LATPase H+ transporting accessory protein 1 like. (204 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
NRDCNardilysin convertase. (1210 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
GAB2GRB2 associated binding protein 2. (651 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
KLBKlotho beta. (1044 aa)
PDE3BPhosphodiesterase. (791 aa)
ERASES cell expressed Ras. (233 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
FGFR3Receptor protein-tyrosine kinase. (583 aa)
ENSNLEP00000024927Uncharacterized protein. (66 aa)
ATP6V0BUncharacterized protein; Belongs to the V-ATPase proteolipid subunit family. (258 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (361 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (124 aa)
ATP6V0E1Uncharacterized protein. (46 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ENSNLEP00000032219V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (87 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
LOC100605369Uncharacterized protein. (571 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
CNSTConsortin, connexin sorting protein. (725 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (387 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (204 aa)
ENSNLEP00000045775Uncharacterized protein. (113 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
KLKlotho. (855 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (528 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
INSRInsulin receptor. (1232 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
G1QHL5_NOMLEUncharacterized protein; Belongs to the heparin-binding growth factors family. (182 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
GRB10Growth factor receptor bound protein 10. (612 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSNLEP00000041179Spem1 domain-containing protein. (269 aa)
IDEInsulin degrading enzyme. (976 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1734 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (147 aa)
ATP6V0E2Uncharacterized protein. (180 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (595 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
FLT3LGUncharacterized protein. (223 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
LIM2Lens intrinsic membrane protein 2. (191 aa)
PIK3R2Uncharacterized protein. (727 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
G1R620_NOMLETIR domain-containing protein. (1031 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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