node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSDE1 | GRB2 | ENSNLEP00000038112 | ENSNLEP00000040743 | Cold shock domain containing E1. | Growth factor receptor bound protein 2. | 0.606 |
CSDE1 | MET | ENSNLEP00000038112 | ENSNLEP00000024614 | Cold shock domain containing E1. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.588 |
CSDE1 | NRAS | ENSNLEP00000038112 | ENSNLEP00000040445 | Cold shock domain containing E1. | NRAS proto-oncogene, GTPase. | 0.494 |
CSDE1 | SOS1 | ENSNLEP00000038112 | ENSNLEP00000019976 | Cold shock domain containing E1. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.659 |
ENSNLEP00000039370 | GRB2 | ENSNLEP00000039370 | ENSNLEP00000040743 | SH2 domain-containing protein. | Growth factor receptor bound protein 2. | 0.979 |
ENSNLEP00000039370 | HGF | ENSNLEP00000039370 | ENSNLEP00000023996 | SH2 domain-containing protein. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.541 |
ENSNLEP00000039370 | HRAS | ENSNLEP00000039370 | ENSNLEP00000010109 | SH2 domain-containing protein. | HRas proto-oncogene, GTPase. | 0.598 |
ENSNLEP00000039370 | KRAS | ENSNLEP00000039370 | ENSNLEP00000006371 | SH2 domain-containing protein. | KRAS proto-oncogene, GTPase. | 0.434 |
ENSNLEP00000039370 | MET | ENSNLEP00000039370 | ENSNLEP00000024614 | SH2 domain-containing protein. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.779 |
ENSNLEP00000039370 | SOS1 | ENSNLEP00000039370 | ENSNLEP00000019976 | SH2 domain-containing protein. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.932 |
ENSNLEP00000046563 | GRB2 | ENSNLEP00000046563 | ENSNLEP00000040743 | Uncharacterized protein. | Growth factor receptor bound protein 2. | 0.979 |
ENSNLEP00000046563 | HGF | ENSNLEP00000046563 | ENSNLEP00000023996 | Uncharacterized protein. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.541 |
ENSNLEP00000046563 | HRAS | ENSNLEP00000046563 | ENSNLEP00000010109 | Uncharacterized protein. | HRas proto-oncogene, GTPase. | 0.598 |
ENSNLEP00000046563 | KRAS | ENSNLEP00000046563 | ENSNLEP00000006371 | Uncharacterized protein. | KRAS proto-oncogene, GTPase. | 0.434 |
ENSNLEP00000046563 | MET | ENSNLEP00000046563 | ENSNLEP00000024614 | Uncharacterized protein. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.779 |
ENSNLEP00000046563 | SOS1 | ENSNLEP00000046563 | ENSNLEP00000019976 | Uncharacterized protein. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.932 |
ERAS | GRB2 | ENSNLEP00000022477 | ENSNLEP00000040743 | ES cell expressed Ras. | Growth factor receptor bound protein 2. | 0.606 |
ERAS | HGF | ENSNLEP00000022477 | ENSNLEP00000023996 | ES cell expressed Ras. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.425 |
ERAS | HRAS | ENSNLEP00000022477 | ENSNLEP00000010109 | ES cell expressed Ras. | HRas proto-oncogene, GTPase. | 0.513 |
ERAS | MET | ENSNLEP00000022477 | ENSNLEP00000024614 | ES cell expressed Ras. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.618 |