STRINGSTRING
SOS1 SOS1 SHC1 SHC1 HRAS HRAS LOC100581909 LOC100581909 RANBP9 RANBP9 ENSNLEP00000046563 ENSNLEP00000046563 RANBP10 RANBP10 GRB2 GRB2 NRAS NRAS ENSNLEP00000039370 ENSNLEP00000039370 CSDE1 CSDE1 KRAS KRAS MET MET HGF HGF ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
SHC1SHC adaptor protein 1. (542 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LOC100581909Uncharacterized protein. (510 aa)
RANBP9Uncharacterized protein. (593 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
RANBP10RAN binding protein 10. (655 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ERASES cell expressed Ras. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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