STRINGSTRING
PTPN11 PTPN11 PRKCA PRKCA GRB7 GRB7 SHANK3 SHANK3 PIK3CB PIK3CB GAB1 GAB1 FNDC3B FNDC3B PIK3CA PIK3CA PIK3R2 PIK3R2 PLCG1 PLCG1 DOK5 DOK5 NXPE1 NXPE1 NXPE4 NXPE4 NXPE2 NXPE2 GFRA4 GFRA4 GAB4 GAB4 MAPK7 MAPK7 GFRA3 GFRA3 PIK3CD PIK3CD SHC1 SHC1 NRTN NRTN RET RET SOS1 SOS1 GAB2 GAB2 DOK2 DOK2 ENSNLEP00000024736 ENSNLEP00000024736 PRKACA PRKACA DOK4 DOK4 ENSNLEP00000027584 ENSNLEP00000027584 GDNF GDNF PRKACB PRKACB GFRA2 GFRA2 RAP1GAP RAP1GAP PDLIM5 PDLIM5 PDLIM7 PDLIM7 PIK3R1 PIK3R1 ENSNLEP00000032399 ENSNLEP00000032399 LOC100605369 LOC100605369 SHC3 SHC3 FRS2 FRS2 ENSNLEP00000037881 ENSNLEP00000037881 GRB10 GRB10 PRKACG PRKACG FNDC3A FNDC3A ENSNLEP00000039370 ENSNLEP00000039370 GRB2 GRB2 LDB3 LDB3 GFRA1 GFRA1 ENSNLEP00000043688 ENSNLEP00000043688 DOK1 DOK1 PIK3R3 PIK3R3 DOK6 DOK6 IRS2 IRS2 ENSNLEP00000046563 ENSNLEP00000046563 SRC SRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
GRB7Growth factor receptor bound protein 7. (476 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1521 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1182 aa)
DOK5Docking protein 5. (306 aa)
NXPE1Uncharacterized protein. (547 aa)
NXPE4Neurexophilin and PC-esterase domain family member 4. (544 aa)
NXPE2Neurexophilin and PC-esterase domain family member 2. (554 aa)
GFRA4Uncharacterized protein. (269 aa)
GAB4GRB2 associated binding protein family member 4. (575 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
GFRA3GDNF family receptor alpha 3. (401 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1077 aa)
SHC1SHC adaptor protein 1. (542 aa)
NRTNNeurturin. (197 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
GAB2GRB2 associated binding protein 2. (651 aa)
DOK2Docking protein 2. (412 aa)
ENSNLEP00000024736Uncharacterized protein. (489 aa)
PRKACAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (294 aa)
DOK4Docking protein 4. (373 aa)
ENSNLEP00000027584SH2 domain-containing protein. (188 aa)
GDNFTGF_BETA_2 domain-containing protein. (169 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GFRA2Uncharacterized protein. (339 aa)
RAP1GAPRAP1 GTPase activating protein. (696 aa)
PDLIM5PDZ and LIM domain 5. (619 aa)
PDLIM7Uncharacterized protein. (368 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
LOC100605369Uncharacterized protein. (571 aa)
SHC3SHC adaptor protein 3. (598 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
ENSNLEP00000037881IRS-type PTB domain-containing protein. (227 aa)
GRB10Growth factor receptor bound protein 10. (612 aa)
PRKACGUncharacterized protein. (290 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LDB3LIM domain binding 3. (724 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
ENSNLEP00000043688Uncharacterized protein. (273 aa)
DOK1Docking protein 1. (481 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
DOK6Docking protein 6. (334 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
SRCTyrosine-protein kinase. (537 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.