STRINGSTRING
PSMA2 PSMA2 PSMC5 PSMC5 CBFB CBFB PSMB10 PSMB10 MAML3 MAML3 KRAS KRAS FNDC3B FNDC3B MYC MYC CTNNB1 CTNNB1 PSMD11 PSMD11 ITGA4 ITGA4 RBPJL RBPJL PSMB8 PSMB8 PSMB9 PSMB9 NOTCH1 NOTCH1 PSMC2 PSMC2 SPP1 SPP1 TP53 TP53 CREBBP CREBBP PSMD4 PSMD4 PSMB4 PSMB4 KAT2A KAT2A SMAD4 SMAD4 PSMC6 PSMC6 PSMA3 PSMA3 HDAC4 HDAC4 MAMLD1 MAMLD1 TGFB1 TGFB1 PSMC4 PSMC4 JAG1 JAG1 CCN2 CCN2 PSMC3 PSMC3 SMURF2 SMURF2 PSMA7 PSMA7 ITGAL ITGAL TCF7L2 TCF7L2 PSMD8 PSMD8 RBPJ RBPJ PSMC1 PSMC1 PSMD5 PSMD5 TEAD1 TEAD1 ERAS ERAS RPS27A-2 RPS27A-2 FOXO3 FOXO3 PSMA1 PSMA1 KAT2B KAT2B BRD2 BRD2 ENSNLEP00000026115 ENSNLEP00000026115 MAML2 MAML2 ENSNLEP00000026783 ENSNLEP00000026783 LOC100591996 LOC100591996 PSMD12 PSMD12 PSMA5 PSMA5 PSMA6 PSMA6 LOC100582822 LOC100582822 ZFHX2 ZFHX2 SNW1 SNW1 PSMA4 PSMA4 ENSNLEP00000029611 ENSNLEP00000029611 ENSNLEP00000029825 ENSNLEP00000029825 PSMD10 PSMD10 YAP1 YAP1 CCND1 CCND1 ENSNLEP00000031906 ENSNLEP00000031906 ZFHX3 ZFHX3 PSMD14 PSMD14 PSME1 PSME1 ENSNLEP00000032543 ENSNLEP00000032543 PSMD7 PSMD7 PSMB1 PSMB1 ENSNLEP00000034619 ENSNLEP00000034619 LEF1 LEF1 EP300 EP300 PSME2 PSME2 PSMF1 PSMF1 ENSNLEP00000036789 ENSNLEP00000036789 PSMB6 PSMB6 ENSNLEP00000037007 ENSNLEP00000037007 ENSNLEP00000037583 ENSNLEP00000037583 ENSNLEP00000037880 ENSNLEP00000037880 ENSNLEP00000038401 ENSNLEP00000038401 ENSNLEP00000038579 ENSNLEP00000038579 ENSNLEP00000038869 ENSNLEP00000038869 FNDC3A FNDC3A ENSNLEP00000039157 ENSNLEP00000039157 ENSNLEP00000039192 ENSNLEP00000039192 PSME3 PSME3 ENSNLEP00000040208 ENSNLEP00000040208 PSMB5 PSMB5 TEAD4 TEAD4 ENSNLEP00000041226 ENSNLEP00000041226 SMAD3 SMAD3 RUNX1 RUNX1 PSMD1 PSMD1 TEAD2 TEAD2 ENSNLEP00000042742 ENSNLEP00000042742 PSMD2 PSMD2 PSMB2 PSMB2 RPS27A RPS27A TEAD3 TEAD3 PSMD6 PSMD6 ENSNLEP00000046239 ENSNLEP00000046239 PSMB7 PSMB7 RUNX3 RUNX3 PSMD13 PSMD13 TCF7 TCF7 WWTR1 WWTR1 BCL2L11 BCL2L11 NINJ2 NINJ2 ZFHX4 ZFHX4 MAML1 MAML1 PSMD3 PSMD3 TCF7L1 TCF7L1 PSMD9 PSMD9 SMURF1 SMURF1 ENSNLEP00000048393 ENSNLEP00000048393 SRC SRC RORC RORC ENSNLEP00000049245 ENSNLEP00000049245 PSMB3 PSMB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMA2Proteasome subunit alpha type. (234 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
CBFBCore-binding factor subunit beta. (182 aa)
PSMB10Proteasome subunit beta. (272 aa)
MAML3Mastermind like transcriptional coactivator 3. (1133 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
CTNNB1Catenin beta 1. (781 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
RBPJLBTD domain-containing protein. (379 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB9Proteasome subunit beta. (219 aa)
NOTCH1Notch receptor 1. (2451 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (361 aa)
CREBBPCREB binding protein. (2442 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
KAT2AUncharacterized protein. (476 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1051 aa)
MAMLD1Mastermind like domain containing 1. (988 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1157 aa)
CCN2Cellular communication network factor 2. (349 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
SMURF2E3 ubiquitin-protein ligase. (745 aa)
PSMA7Proteasome subunit alpha type. (265 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1142 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (527 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (509 aa)
TEAD1TEA domain transcription factor 1. (426 aa)
ERASES cell expressed Ras. (233 aa)
RPS27A-2Ubiquitin-like domain-containing protein. (156 aa)
FOXO3Forkhead box O3. (672 aa)
PSMA1Proteasome subunit alpha type. (268 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (799 aa)
BRD2Bromodomain containing 2. (827 aa)
ENSNLEP00000026115AAA domain-containing protein. (339 aa)
MAML2Uncharacterized protein. (593 aa)
ENSNLEP00000026783MamL-1 domain-containing protein. (184 aa)
LOC100591996Proteasome endopeptidase complex. (164 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (488 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMA6Proteasome subunit alpha type. (206 aa)
LOC100582822Uncharacterized protein. (379 aa)
ZFHX2Zinc finger homeobox 2. (2554 aa)
SNW1SNW domain containing 1. (571 aa)
PSMA4Proteasome subunit alpha type. (241 aa)
ENSNLEP00000029611Proteasome subunit beta. (202 aa)
ENSNLEP00000029825Uncharacterized protein. (351 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
YAP1Uncharacterized protein. (418 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ENSNLEP00000031906Uncharacterized protein. (406 aa)
ZFHX3Zinc finger homeobox 3. (3274 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (315 aa)
PSME1Proteasome activator subunit 1. (250 aa)
ENSNLEP00000032543Uncharacterized protein. (168 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMB1Proteasome subunit beta. (241 aa)
ENSNLEP00000034619Ubiquitin-like domain-containing protein. (77 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
EP300E1A binding protein p300. (2306 aa)
PSME2Proteasome activator subunit 2. (256 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ENSNLEP00000036789SKIP_SNW domain-containing protein. (443 aa)
PSMB6Proteasome subunit beta. (244 aa)
ENSNLEP00000037007Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (786 aa)
ENSNLEP00000037583Ubiquitin-like domain-containing protein. (79 aa)
ENSNLEP00000037880Uncharacterized protein. (341 aa)
ENSNLEP00000038401ANK_REP_REGION domain-containing protein. (141 aa)
ENSNLEP00000038579Ubiquitin-like domain-containing protein. (104 aa)
ENSNLEP00000038869Ubiquitin-like domain-containing protein. (156 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSNLEP00000039157CSN8_PSD8_EIF3K domain-containing protein. (225 aa)
ENSNLEP00000039192Uncharacterized protein. (179 aa)
PSME3Proteasome activator subunit 3. (239 aa)
ENSNLEP00000040208AAA domain-containing protein. (406 aa)
PSMB5Proteasome subunit beta. (263 aa)
TEAD4TEA domain transcription factor 4. (420 aa)
ENSNLEP00000041226ATPase_AAA_core domain-containing protein. (461 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (485 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (957 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
ENSNLEP00000042742Proteasome subunit alpha type. (233 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMB2Proteasome subunit beta. (201 aa)
RPS27AUbiquitin-like domain-containing protein. (161 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
ENSNLEP00000046239Prot_ATP_ID_OB domain-containing protein. (183 aa)
PSMB7Proteasome subunit beta. (277 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (396 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (397 aa)
TCF7HMG box domain-containing protein. (486 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
NINJ2Ninjurin 2. (189 aa)
ZFHX4Zinc finger homeobox 4. (3349 aa)
MAML1Mastermind like transcriptional coactivator 1. (1016 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (528 aa)
TCF7L1Transcription factor 7 like 1. (517 aa)
PSMD9PDZ domain-containing protein. (222 aa)
SMURF1E3 ubiquitin-protein ligase. (749 aa)
ENSNLEP00000048393VWFA domain-containing protein. (326 aa)
SRCTyrosine-protein kinase. (537 aa)
RORCRAR related orphan receptor C. (511 aa)
ENSNLEP00000049245AAA domain-containing protein. (394 aa)
PSMB3Proteasome subunit beta. (205 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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