STRINGSTRING
AKT1 AKT1 GNB1 GNB1 PRKCZ PRKCZ MMP2 MMP2 MAPK3 MAPK3 SPHK1 SPHK1 GNG8 GNG8 STRN4 STRN4 GNGT2 GNGT2 PRMT8 PRMT8 ELK1 ELK1 WDR64 WDR64 NOS3 NOS3 GNG3 GNG3 SRF SRF KRAS KRAS PRMT1 PRMT1 PIK3CA PIK3CA GNB4 GNB4 PIK3R2 PIK3R2 MMP9 MMP9 GNAI2 GNAI2 CREB1 CREB1 MMP7 MMP7 MMP3 MMP3 EREG EREG BTC BTC HRAS HRAS S1PR3 S1PR3 HBEGF HBEGF LOC100592336 LOC100592336 GNAI1 GNAI1 XPO1 XPO1 GNG5 GNG5 TGFA TGFA ZDHHC7 ZDHHC7 CAV2 CAV2 SHC1 SHC1 GNB2 GNB2 ESR2 ESR2 GNAT3 GNAT3 ESR1 ESR1 GNGT1 GNGT1 GNG11 GNG11 STRN STRN EGF EGF ZDHHC21 ZDHHC21 ERAS ERAS UHMK1 UHMK1 FOXO3 FOXO3 AKT3 AKT3 CDKN1B CDKN1B HSP90AA1 HSP90AA1 GNG13 GNG13 GNG4 GNG4 MAPK1 MAPK1 LOC100586578 LOC100586578 ENSNLEP00000028868 ENSNLEP00000028868 GNB3 GNB3 GNG2 GNG2 LOC100583914 LOC100583914 GNB5 GNB5 CCND1 CCND1 PIK3R1 PIK3R1 CAV1 CAV1 ENSNLEP00000032399 ENSNLEP00000032399 PTK2 PTK2 EGFR EGFR BCL2 BCL2 CSDE1 CSDE1 ENSNLEP00000039370 ENSNLEP00000039370 GNG12 GNG12 GNG7 GNG7 AREG AREG NRAS NRAS LOC100593010 LOC100593010 GNAI3 GNAI3 AKT2 AKT2 IGF1R IGF1R PIK3R3 PIK3R3 ENSNLEP00000046563 ENSNLEP00000046563 FOS FOS EPGN EPGN STRN3 STRN3 SRC SRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
GNB1G protein subunit beta 1. (340 aa)
PRKCZProtein kinase C zeta. (507 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
MAPK3Mitogen-activated protein kinase. (278 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
STRN4Striatin 4. (713 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (366 aa)
ELK1ETS transcription factor ELK1. (390 aa)
WDR64WD repeat domain 64. (1052 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SRFSerum response factor. (508 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (323 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3R2Uncharacterized protein. (727 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MMP7Matrix metallopeptidase 7. (267 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
EREGEpiregulin. (169 aa)
BTCBetacellulin. (178 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
GNAI1G protein subunit alpha i1. (353 aa)
XPO1Exportin 1. (1091 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TGFATransforming growth factor alpha. (166 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (345 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
SHC1SHC adaptor protein 1. (542 aa)
GNB2G protein subunit beta 2. (325 aa)
ESR2Estrogen receptor 2. (530 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
STRNStriatin. (702 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
ERASES cell expressed Ras. (233 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
FOXO3Forkhead box O3. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CDKN1BUncharacterized protein. (204 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (116 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
LOC100586578Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ENSNLEP00000028868G protein gamma domain-containing protein. (64 aa)
GNB3G protein subunit beta 3. (335 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
LOC100583914Uncharacterized protein. (322 aa)
GNB5G protein subunit beta 5. (357 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSNLEP00000032399Uncharacterized protein. (628 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ENSNLEP00000039370SH2 domain-containing protein. (299 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
AREGEGF-like domain-containing protein. (274 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC100593010Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
GNAI3G protein subunit alpha i3. (354 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
IGF1RTyrosine-protein kinase receptor. (1199 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ENSNLEP00000046563Uncharacterized protein. (498 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EPGNEpithelial mitogen. (154 aa)
STRN3Striatin 3. (797 aa)
SRCTyrosine-protein kinase. (537 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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