STRINGSTRING
EGR2 EGR2 FOSB FOSB ELK1 ELK1 CDK5 CDK5 RRAD RRAD SRF SRF CHD4 CHD4 TRIB1 TRIB1 FOSL1 FOSL1 CREB1 CREB1 REST REST EGR1 EGR1 ID1 ID1 SH3GL3 SH3GL3 F3 F3 LYL1 LYL1 ID2 ID2 TRIB2 TRIB2 SGK1 SGK1 EGR3 EGR3 NAB2 NAB2 TPH1 TPH1 ATF1 ATF1 CDK5R2 CDK5R2 NAB1 NAB1 ID3 ID3 ASCL1 ASCL1 DNM2 DNM2 ENSNLEP00000029200 ENSNLEP00000029200 TCF12 TCF12 ATF2 ATF2 JUNB JUNB EP300 EP300 ENSNLEP00000036861 ENSNLEP00000036861 MEF2D MEF2D ENSNLEP00000042687 ENSNLEP00000042687 ASCL2 ASCL2 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGR2Early growth response 2. (476 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
ELK1ETS transcription factor ELK1. (390 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
SRFSerum response factor. (508 aa)
CHD4Uncharacterized protein. (1987 aa)
TRIB1Tribbles pseudokinase 1. (321 aa)
FOSL1BZIP domain-containing protein. (271 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
RESTRE1 silencing transcription factor. (1097 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (355 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
EGR3Early growth response 3. (387 aa)
NAB2NGFI-A binding protein 2. (525 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
ATF1Activating transcription factor 1. (270 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
NAB1NGFI-A binding protein 1. (487 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (770 aa)
ENSNLEP00000029200C2H2-type domain-containing protein. (398 aa)
TCF12Transcription factor 12. (706 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (327 aa)
EP300E1A binding protein p300. (2306 aa)
ENSNLEP00000036861Uncharacterized protein. (119 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
ENSNLEP00000042687Uncharacterized protein. (245 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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