STRINGSTRING
TXN TXN RBL2 RBL2 RETN RETN POMC POMC FOXO1 FOXO1 STK11 STK11 BCL2L11 BCL2L11 HDAC1 HDAC1 IGFBP1 IGFBP1 AGRP AGRP NFYA NFYA KLF2 KLF2 TXNIP TXNIP MSTN MSTN YWHAB YWHAB PCBP4 PCBP4 PCK1 PCK1 CCNG2 CCNG2 TRIM63 TRIM63 GADD45A GADD45A BCL6B BCL6B CREBBP CREBBP SOD2 SOD2 SMAD4 SMAD4 G6PC G6PC SIRT1 SIRT1 NFYC NFYC PLXNA4 PLXNA4 YWHAQ YWHAQ CITED2 CITED2 FASLG FASLG SIRT3 SIRT3 DDIT3 DDIT3 GDF11 GDF11 CAT CAT SFN SFN SMAD2 SMAD2 FOXO3 FOXO3 AKT3 AKT3 NR3C1 NR3C1 PINK1 PINK1 CDKN1B CDKN1B KAT2B KAT2B ENSNLEP00000026050 ENSNLEP00000026050 ENSNLEP00000026622 ENSNLEP00000026622 GCK GCK AKT1 AKT1 YWHAZ YWHAZ ENSNLEP00000029280 ENSNLEP00000029280 KLF4 KLF4 NFYB NFYB LOC100606984 LOC100606984 ENSNLEP00000031088 ENSNLEP00000031088 SREBF1 SREBF1 ENSNLEP00000032236 ENSNLEP00000032236 BTG1 BTG1 LOC100595437 LOC100595437 EP300 EP300 ENSNLEP00000037007 ENSNLEP00000037007 ENSNLEP00000037515 ENSNLEP00000037515 HDAC2 HDAC2 FOXO4 FOXO4 ENSNLEP00000038791 ENSNLEP00000038791 BCL6 BCL6 ENSNLEP00000039177 ENSNLEP00000039177 ENSNLEP00000039561 ENSNLEP00000039561 SMAD3 SMAD3 PPARGC1A PPARGC1A AKT2 AKT2 ENSNLEP00000043421 ENSNLEP00000043421 SIN3A SIN3A ATXN3 ATXN3 ENSNLEP00000049027 ENSNLEP00000049027 ENSNLEP00000046431 ENSNLEP00000046431 FBXO32 FBXO32
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TXNThioredoxin domain-containing protein. (97 aa)
RBL2RB transcriptional corepressor like 2. (1138 aa)
RETNResistin. (108 aa)
POMCProopiomelanocortin. (243 aa)
FOXO1Forkhead box O1. (652 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (423 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
AGRPAgouti related neuropeptide. (132 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
KLF2Kruppel like factor 2. (355 aa)
TXNIPThioredoxin interacting protein. (391 aa)
MSTNMyostatin. (376 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
PCBP4Poly(rC) binding protein 4. (403 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
TRIM63Tripartite motif containing 63. (333 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
BCL6BBCL6B transcription repressor. (478 aa)
CREBBPCREB binding protein. (2442 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SIRT1Sirtuin 1. (734 aa)
NFYCNuclear transcription factor Y subunit gamma. (401 aa)
PLXNA4Plexin A4. (1864 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (253 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
GDF11TGF_BETA_2 domain-containing protein. (377 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FOXO3Forkhead box O3. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (778 aa)
PINK1Protein kinase domain-containing protein. (563 aa)
CDKN1BUncharacterized protein. (204 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (799 aa)
ENSNLEP0000002605014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (241 aa)
ENSNLEP0000002662214_3_3 domain-containing protein; Belongs to the 14-3-3 family. (230 aa)
GCKPhosphotransferase. (427 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
ENSNLEP0000002928014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (230 aa)
KLF4Uncharacterized protein. (145 aa)
NFYBNuclear transcription factor Y subunit beta. (208 aa)
LOC100606984CBFD_NFYB_HMF domain-containing protein. (202 aa)
ENSNLEP00000031088Protein kinase domain-containing protein. (557 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
ENSNLEP00000032236Uncharacterized protein. (109 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
LOC100595437Thioredoxin domain-containing protein. (105 aa)
EP300E1A binding protein p300. (2306 aa)
ENSNLEP00000037007Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (786 aa)
ENSNLEP00000037515Thioredoxin; Belongs to the thioredoxin family. (105 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
FOXO4Forkhead box O4. (505 aa)
ENSNLEP00000038791Uncharacterized protein. (63 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSNLEP0000003917714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (207 aa)
ENSNLEP0000003956114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (398 aa)
ENSNLEP00000043421Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (393 aa)
SIN3ASIN3 transcription regulator family member A. (1250 aa)
ATXN3Ataxin 3. (354 aa)
ENSNLEP00000049027Thioredoxin domain-containing protein. (90 aa)
ENSNLEP00000046431Thioredoxin; Belongs to the thioredoxin family. (101 aa)
FBXO32F-box protein 32. (371 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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