35 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NAMPT	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (475 aa)
	REST	RE1 silencing transcription factor. (1097 aa)
	MAGED1	MAGE family member D1. (823 aa)
	NPAS4	Neuronal PAS domain protein 4. (802 aa)
	SYT3	Synaptotagmin 3. (584 aa)
	IQSEC1	IQ motif and Sec7 domain 1. (1098 aa)
	MOV10	Mov10 RISC complex RNA helicase. (976 aa)
	SRF	Serum response factor. (508 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (320 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
	PLK2	Serine/threonine-protein kinase PLK. (685 aa)
	MAPK3	Mitogen-activated protein kinase. (278 aa)
	G1QMG8_NOMLE	SEC7 domain-containing protein. (970 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (847 aa)
	G1QGZ3_NOMLE	RRM domain-containing protein. (267 aa)
	KCNIP3	Uncharacterized protein. (231 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator. (789 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	ENSNLEP00000036861	Uncharacterized protein. (119 aa)
	ARNT2	Uncharacterized protein. (699 aa)
	TNRC6B	Trinucleotide repeat containing adaptor 6B. (1727 aa)
	SYT6	Uncharacterized protein. (480 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
	ARNTL2	Aryl hydrocarbon receptor nuclear translocator like 2. (636 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (778 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (620 aa)
	SYT10	Synaptotagmin 10. (523 aa)
	LOC100590915	SEC7 domain-containing protein. (1316 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
	AGO3	Argonaute RISC catalytic component 3; Belongs to the argonaute family. (845 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (854 aa)
	CREBBP	CREB binding protein. (2442 aa)
	XPO1	Exportin 1. (1091 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSNLEP00000013638	ENSNLEP00000001761	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.997
AGO1	AGO3	ENSNLEP00000013638	ENSNLEP00000013603	Argonaute RISC component 1; Belongs to the argonaute family.	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	0.934
AGO1	AGO4	ENSNLEP00000013638	ENSNLEP00000013572	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.877
AGO1	MOV10	ENSNLEP00000013638	ENSNLEP00000005118	Argonaute RISC component 1; Belongs to the argonaute family.	Mov10 RISC complex RNA helicase.	0.838
AGO1	TNRC6B	ENSNLEP00000013638	ENSNLEP00000034946	Argonaute RISC component 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6B.	0.966
AGO2	AGO1	ENSNLEP00000001761	ENSNLEP00000013638	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.997
AGO2	AGO3	ENSNLEP00000001761	ENSNLEP00000013603	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	0.987
AGO2	AGO4	ENSNLEP00000001761	ENSNLEP00000013572	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.950
AGO2	MOV10	ENSNLEP00000001761	ENSNLEP00000005118	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Mov10 RISC complex RNA helicase.	0.911
AGO2	TNRC6B	ENSNLEP00000001761	ENSNLEP00000034946	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Trinucleotide repeat containing adaptor 6B.	0.978
AGO2	XPO1	ENSNLEP00000001761	ENSNLEP00000011815	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exportin 1.	0.510
AGO3	AGO1	ENSNLEP00000013603	ENSNLEP00000013638	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	Argonaute RISC component 1; Belongs to the argonaute family.	0.934
AGO3	AGO2	ENSNLEP00000013603	ENSNLEP00000001761	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.987
AGO3	AGO4	ENSNLEP00000013603	ENSNLEP00000013572	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.839
AGO3	CREBBP	ENSNLEP00000013603	ENSNLEP00000011912	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	CREB binding protein.	0.549
AGO3	TNRC6B	ENSNLEP00000013603	ENSNLEP00000034946	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6B.	0.933
AGO4	AGO1	ENSNLEP00000013572	ENSNLEP00000013638	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Argonaute RISC component 1; Belongs to the argonaute family.	0.877
AGO4	AGO2	ENSNLEP00000013572	ENSNLEP00000001761	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.950
AGO4	AGO3	ENSNLEP00000013572	ENSNLEP00000013603	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Argonaute RISC catalytic component 3; Belongs to the argonaute family.	0.839
AGO4	TNRC6B	ENSNLEP00000013572	ENSNLEP00000034946	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Trinucleotide repeat containing adaptor 6B.	0.829

page 1 of 7

Server load: low (26%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About