STRINGSTRING
LIPE LIPE CLEC10A CLEC10A PCK1 PCK1 CTSL CTSL CD4 CD4 NOS3 NOS3 IFNG IFNG NOS2 NOS2 FOXO1 FOXO1 NOS1 NOS1 LEPR LEPR IL1B IL1B CD36 CD36 IRS2 IRS2 CPT1A CPT1A IL6 IL6 GPAT4 GPAT4 IL10 IL10 ACOX1 ACOX1 PRKACB PRKACB UCP2 UCP2 PPARA PPARA INS-IGF2 INS-IGF2 LEP LEP G6PC G6PC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIPELipase E, hormone sensitive type. (1072 aa)
CLEC10AC-type lectin domain containing 10A. (316 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
CD4CD4 molecule. (458 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
FOXO1Forkhead box O1. (652 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
LEPRLeptin receptor. (1165 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CD36CD36 molecule; Belongs to the CD36 family. (433 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (680 aa)
IL6Uncharacterized protein. (258 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
IL10Interleukin 10. (178 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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