STRINGSTRING
MAPK12 MAPK12 RPS6KB1 RPS6KB1 MED1 MED1 ADCY3 ADCY3 MMP2 MMP2 BRAF BRAF RB1 RB1 PIK3CB PIK3CB ABCB11 ABCB11 BAX BAX KRAS KRAS NOTCH2 NOTCH2 PIK3CA PIK3CA PIK3R2 PIK3R2 MMP9 MMP9 NCOA3 NCOA3 HRAS HRAS E2F2 E2F2 MAPK13 MAPK13 HBEGF HBEGF E2F1 E2F1 ADCY2 ADCY2 SHC1 SHC1 SOS2 SOS2 CARM1 CARM1 ESR2 ESR2 NCOR1 NCOR1 ESR1 ESR1 BIK BIK CDKN2C CDKN2C SOS1 SOS1 CDK4 CDK4 SP1 SP1 LOC101176289 LOC101176289 AKT3 AKT3 RAF1 RAF1 CDKN1B CDKN1B MAPK14 MAPK14 GPER1 GPER1 MAPK10 MAPK10 MAPK1 MAPK1 AKT1 AKT1 DLL1 DLL1 PRKACB PRKACB MAPK9 MAPK9 CCND1 CCND1 PIK3R1 PIK3R1 MTOR MTOR EGFR EGFR SHC3 SHC3 MAP2K1 MAP2K1 BCL2 BCL2 CDKN2A CDKN2A BAD BAD ADCY8 ADCY8 NRAS NRAS DLL3 DLL3 GRB2 GRB2 E2F3 E2F3 IGF1 IGF1 PIK3R3 PIK3R3 MAPK8 MAPK8 ADCY1 ADCY1 FOS FOS ADCY5 ADCY5 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (368 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1558 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
RB1RB transcriptional corepressor 1. (919 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ABCB11ABC transmembrane type-1 domain-containing protein. (659 aa)
BAXUncharacterized protein. (194 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NOTCH2Notch receptor 2. (2444 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
NCOA3Nuclear receptor coactivator. (1419 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
E2F1E2F transcription factor 1. (391 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
SHC1SHC adaptor protein 1. (542 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (563 aa)
ESR2Estrogen receptor 2. (530 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
BIKBCL2 interacting killer. (159 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SP1Sp1 transcription factor. (786 aa)
LOC101176289Uncharacterized protein. (244 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDKN1BUncharacterized protein. (204 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
BADUncharacterized protein. (82 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
E2F3E2F transcription factor 3. (397 aa)
IGF1IlGF domain-containing protein. (196 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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