STRINGSTRING
MAPKAPK5 MAPKAPK5 CRKL CRKL CACNG1 CACNG1 CACNG5 CACNG5 PRKCA PRKCA TAOK3 TAOK3 FLT3 FLT3 GADD45G GADD45G FLT1 FLT1 MAPK12 MAPK12 CRK CRK MAPKAPK2 MAPKAPK2 FGF22 FGF22 FGF16 FGF16 MAP2K7 MAP2K7 PAK2 PAK2 RELB RELB NLK NLK MAP3K1 MAP3K1 BRAF BRAF FLT4 FLT4 MAP2K6 MAP2K6 RPS6KA6 RPS6KA6 PPP5C PPP5C FGF23 FGF23 FGF6 FGF6 NTF3 NTF3 CSF1 CSF1 DUSP16 DUSP16 NTRK2 NTRK2 PLA2G4E PLA2G4E PLA2G4D PLA2G4D RAP1A RAP1A PLA2G4F PLA2G4F TGFBR2 TGFBR2 MRAS MRAS SRF SRF TRADD TRADD FGF21 FGF21 VEGFB VEGFB NTF4 NTF4 KRAS KRAS MYD88 MYD88 KITLG KITLG MYC MYC DUSP3 DUSP3 MAP3K11 MAP3K11 FGF7 FGF7 PRKCG PRKCG CACNG7 CACNG7 CACNG8 CACNG8 RAPGEF2 RAPGEF2 MAP3K13 MAP3K13 MAPKAPK3 MAPKAPK3 ERBB4 ERBB4 CACNA2D3 CACNA2D3 FLNB FLNB EPHA2 EPHA2 EREG EREG CACNA1F CACNA1F PDGFA PDGFA HRAS HRAS KIT KIT FGF5 FGF5 TRAF2 TRAF2 MAPK7 MAPK7 MAPK13 MAPK13 GADD45A GADD45A CD14 CD14 RPS6KA1 RPS6KA1 VEGFD VEGFD MAP3K6 MAP3K6 FGF1 FGF1 RPS6KA3 RPS6KA3 TGFA TGFA CSF1R CSF1R PDGFRB PDGFRB FGF19 FGF19 CASP3 CASP3 EFNA5 EFNA5 MAP3K4 MAP3K4 RASGRP1 RASGRP1 CACNG3 CACNG3 SOS2 SOS2 FAS FAS FGFR1 FGFR1 ECSIT ECSIT FGFR4 FGFR4 IKBKB IKBKB RASGRF2 RASGRF2 MAP2K5 MAP2K5 FGF9 FGF9 DUSP9 DUSP9 NFKB1 NFKB1 MAP3K7 MAP3K7 INS-IGF2 INS-IGF2 RASA1 RASA1 LAMTOR3 LAMTOR3 PPM1A PPM1A TGFB1 TGFB1 FLNA FLNA IKBKG IKBKG ELK4 ELK4 CACNG2 CACNG2 CACNA2D1 CACNA2D1 FGF8 FGF8 ANGPT2 ANGPT2 NFKB2 NFKB2 PDGFB PDGFB TAB1 TAB1 ATF4 ATF4 FASLG FASLG TAB2 TAB2 PPP3CC PPP3CC TEK TEK SOS1 SOS1 MAP4K3 MAP4K3 EGF EGF TGFB3 TGFB3 DUSP4 DUSP4 VEGFC VEGFC PPM1B PPM1B RASGRP4 RASGRP4 FGFR2 FGFR2 ARRB1 ARRB1 MAP3K8 MAP3K8 DDIT3 DDIT3 ARRB2 ARRB2 RRAS2 RRAS2 NR4A1 NR4A1 BDNF BDNF CACNB3 CACNB3 IRAK4 IRAK4 TRAF6 TRAF6 PLA2G4A PLA2G4A PTPN7 PTPN7 HSPA6 HSPA6 RASA2 RASA2 MAP3K2 MAP3K2 IL1R1 IL1R1 AKT3 AKT3 HGF HGF RAF1 RAF1 MAPK14 MAPK14 MET MET MAP3K20 MAP3K20 EFNA3 EFNA3 PDGFD PDGFD CHUK CHUK FGF20 FGF20 HSPB1 HSPB1 MAPK10 MAPK10 EFNA1 EFNA1 MAP2K4 MAP2K4 STK3 STK3 PPP3R1 PPP3R1 PPP3CB PPP3CB MAPK1 MAPK1 GNA12 GNA12 RPS6KA5 RPS6KA5 AKT1 AKT1 STK4 STK4 PRKACB PRKACB FGF10 FGF10 NGF NGF CACNB4 CACNB4 TNFRSF1A TNFRSF1A IGF2 IGF2 RASGRP3 RASGRP3 MAPK9 MAPK9 PPP3CA PPP3CA MAP3K14 MAP3K14 PGF PGF ATF2 ATF2 MAPK8IP2 MAPK8IP2 CACNG4 CACNG4 EGFR EGFR MAP2K1 MAP2K1 RELA RELA RASGRP2 RASGRP2 FGF2 FGF2 MECOM MECOM EFNA2 EFNA2 CACNA2D2 CACNA2D2 PAK1 PAK1 GNG12 GNG12 NFATC1 NFATC1 FGF17 FGF17 PDGFC PDGFC AREG AREG NF1 NF1 NRAS NRAS CACNA2D4 CACNA2D4 GRB2 GRB2 CDC42 CDC42 ANGPT1 ANGPT1 TGFBR1 TGFBR1 EFNA4 EFNA4 RAC2 RAC2 TAOK2 TAOK2 CACNB2 CACNB2 PRKCB PRKCB KDR KDR DUSP6 DUSP6 CACNA1D CACNA1D DUSP5 DUSP5 IL1B IL1B HSPA8 HSPA8 IGF1 IGF1 NFATC3 NFATC3 TAOK1 TAOK1 MAPK8 MAPK8 PTPRR PTPRR STMN1 STMN1 NTRK1 NTRK1 ERBB3 ERBB3 FOS FOS DUSP10 DUSP10 TNF TNF MAP3K5 MAP3K5 ERBB2 ERBB2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MAPKAPK5MAPK activated protein kinase 5. (471 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
TAOK3TAO kinase 3. (898 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
CRKUncharacterized protein. (252 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
RELBRELB proto-oncogene, NF-kB subunit. (586 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1461 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RPS6KA6Ribosomal protein S6 kinase. (738 aa)
PPP5CSerine/threonine-protein phosphatase. (499 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
DUSP16Dual specificity phosphatase 16. (662 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
PLA2G4EPhospholipase A2. (867 aa)
PLA2G4DPhospholipase A2. (818 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PLA2G4FPhospholipase A2. (850 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
SRFSerum response factor. (508 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (271 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (424 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1642 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (958 aa)
FLNBFilamin B. (2585 aa)
EPHA2EPH receptor A2. (976 aa)
EREGEpiregulin. (169 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1254 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
TGFATransforming growth factor alpha. (166 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1592 aa)
RASGRP1RAS guanyl releasing protein 1. (785 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
FASFas cell surface death receptor. (335 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
ECSITECSIT_Cterm domain-containing protein. (416 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1232 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (414 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (383 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FLNAFilamin A. (2626 aa)
IKBKGNEMO domain-containing protein. (173 aa)
ELK4ETS transcription factor ELK4. (431 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1071 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
ANGPT2Angiopoietin 2. (496 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ATF4BZIP domain-containing protein. (351 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (894 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
PPM1BPPM-type phosphatase domain-containing protein. (387 aa)
RASGRP4RAS guanyl releasing protein 4. (673 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
ARRB1Arrestin beta 1. (418 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
ARRB2Arrestin beta 2. (430 aa)
RRAS2RAS related 2. (204 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (444 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PLA2G4APhospholipase A2. (749 aa)
PTPN7Protein tyrosine phosphatase non-receptor type 7. (465 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
RASA2RAS p21 protein activator 2. (849 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (622 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
HSPB1Uncharacterized protein. (37 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (204 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
STK3Serine/threonine kinase 3. (519 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
GNA12G protein subunit alpha 12. (381 aa)
RPS6KA5Ribosomal protein S6 kinase. (797 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
STK4Serine/threonine kinase 4. (490 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (502 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IGF2IlGF domain-containing protein. (180 aa)
RASGRP3RAS guanyl releasing protein 3. (690 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (939 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MAPK8IP2PID domain-containing protein. (178 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RASGRP2RAS guanyl releasing protein 2. (610 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
MECOMMDS1 and EVI1 complex locus. (1230 aa)
EFNA2Ephrin RBD domain-containing protein; Belongs to the ephrin family. (195 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1119 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
AREGEGF-like domain-containing protein. (274 aa)
NF1Neurofibromin 1. (2839 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CACNA2D4VWFA domain-containing protein. (587 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42Cell division cycle 42. (191 aa)
ANGPT1Angiopoietin 1. (498 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
EFNA4Ephrin RBD domain-containing protein; Belongs to the ephrin family. (201 aa)
RAC2Rac family small GTPase 2. (192 aa)
TAOK2TAO kinase 2. (1246 aa)
CACNB2GuKc domain-containing protein. (586 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IGF1IlGF domain-containing protein. (196 aa)
NFATC3Nuclear factor of activated T cells 3. (1045 aa)
TAOK1TAO kinase 1. (1002 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (657 aa)
STMN1Stathmin; Belongs to the stathmin family. (172 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
DUSP10Dual specificity phosphatase 10. (482 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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