STRINGSTRING
CRKL CRKL PRKCA PRKCA RPS6KB1 RPS6KB1 CRK CRK MAP2K7 MAP2K7 PAK2 PAK2 BRAF BRAF PAK6 PAK6 NCK1 NCK1 PIK3CB PIK3CB KRAS KRAS GAB1 GAB1 MYC MYC PIK3CA PIK3CA PIK3R2 PIK3R2 PRKCG PRKCG ERBB4 ERBB4 CBL CBL EREG EREG BTC BTC HRAS HRAS NRG2 NRG2 HBEGF HBEGF TGFA TGFA SHC1 SHC1 SOS2 SOS2 PAK5 PAK5 PAK4 PAK4 ABL2 ABL2 SOS1 SOS1 EGF EGF AKT3 AKT3 M3ZBW0_NOMLE M3ZBW0_NOMLE RAF1 RAF1 CDKN1B CDKN1B MAPK10 MAPK10 GSK3B GSK3B MAP2K4 MAP2K4 MAPK1 MAPK1 AKT1 AKT1 NCK2 NCK2 MAPK9 MAPK9 PIK3R1 PIK3R1 MTOR MTOR EGFR EGFR SHC3 SHC3 MAP2K1 MAP2K1 BAD BAD PAK1 PAK1 AREG AREG NRAS NRAS GRB2 GRB2 PRKCB PRKCB NRG4 NRG4 PIK3R3 PIK3R3 NRG1 NRG1 MAPK8 MAPK8 NRG3 NRG3 ERBB3 ERBB3 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
CRKUncharacterized protein. (252 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
NCK1Cytoplasmic protein. (377 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
CBLCbl proto-oncogene. (905 aa)
EREGEpiregulin. (169 aa)
BTCBetacellulin. (178 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NRG2Uncharacterized protein. (597 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
TGFATransforming growth factor alpha. (166 aa)
SHC1SHC adaptor protein 1. (542 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CDKN1BUncharacterized protein. (204 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
NCK2Cytoplasmic protein. (380 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BADUncharacterized protein. (82 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
AREGEGF-like domain-containing protein. (274 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
NRG4Neuregulin 4. (117 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
NRG1Neuregulin 1. (713 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRG3Neuregulin 3. (720 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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